Biochemists & cryo-EM scientists studying chromosome replication @TheCrick
Joined October 2022
- Tweets 59
- Following 135
- Followers 504
- Likes 95
8 Photos and videos
Pinned Tweet
11 Dec 2024
I have received a Wellcome Discovery Award to study the initiation of eukaryotic DNA replication. 8 years of funding at the Crick Institute.
Looking for a postdoc in molecular mechanism, cryo-EM and in situ structure?
Contact me now! 3 postdoc positions advertised soon.
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20 Jan 2025
How does ATP hydrolysis by MCM enable replicative helicase loading onto DNA?
Find the answer in our latest article
rdcu.be/d6D8D
Congratulations to Agata Butryn, who spearheaded the entire project, Contributions from @GreiweJulia in the early days.
🎉❄️🔬🧬
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11 Dec 2024
I have received a Wellcome Discovery Award to study the initiation of eukaryotic DNA replication. 8 years of funding at the Crick Institute.
Looking for a postdoc in molecular mechanism, cryo-EM and in situ structure?
Contact me now! 3 postdoc positions advertised soon.
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11 Dec 2024
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27 Nov 2024
Our article "MCM double hexamer loading visualized with human proteins" published in Nature today! ❄️🔬🧬🎉🥳
Great collaboration with John Diffley's lab. Congratulations to Florian Weissmann, Julia Greiwe and all other authors! rdcu.be/d1F7m
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Costa Lab retweeted
27 Nov 2024
Our study on how the human MCM2-7 helicase is loaded onto replication origins 🧬 is now online @Nature! 🎉
Our findings reveal that unlike in yeast, human MCM loading does not require ORC6 and can occur through multiple pathways.
Read more here: rdcu.be/d1F6S
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Costa Lab retweeted
5 Nov 2024
Great kickoff for the EMBO EMBL Replication symposium with amazing structural and functional insights into initiation, elongation and histone recycling 🧬♻️ @TyeBik @CostaLabCrick @BleichertLab @Speck_Lab Chistol @Lopes_Lab Méchali @YardimciLab 🙌
#EESReplication @EMBLEvents
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Costa Lab retweeted
6 Sep 2024
Looking forward to this!
6 Sep 2024
A fantastic lineup of speakers for the "Machines acting on DNA and RNA" meeting at @CNIOStopCancer
All things D/RNA! 🧬Replication transcription translation chromatin repair processing🧬
May 28th to 30th, 2025 - Save the date!
@OscarLlorcaCNIO @rfleiro @NogalesLab
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Costa Lab retweeted
26 Jul 2024
⏰ Deadline approaching for #EESReplication ⏰
Submit your abstract by 13 August and find out about the latest breakthroughs in DNA replication 🧪🧬
📅 5 – 8 November
📍 EMBL Heidelberg and Virtual
➡️ s.embl.org/ees24-12
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Costa Lab retweeted
9 Jul 2024
Congratulations to group leaders Snezhka Oliferenko and Alessandro Costa (@CostaLabCrick) on being elected as members of @EMBO 🥳
crick.ac.uk/news-and-reports…
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Costa Lab retweeted
8 Jul 2024
Abstract and early bird deadline for the 2024 UK DNA Replication Meeting is this week. Don't miss out - its going to be a fantastic meeting!
2 Feb 2024
Unlock the latest insights into DNA replication at our 2024 meeting. Dive into the forefront of research and deepen your understanding of this fundamental process. Register today to join leading experts and explore rapid advancements. ow.ly/jaOL50Qvt9K
ALT A Biochemical Society Scientific Meeting UK DNA Replication Meeting 2024 10-12 September 2024, Cambridge, UK Register online: bit.ly/DNARep24 Abstract and Earlybird deadline: 10 July 2024
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17 May 2024
How does Mcm10 activate an origin of replication?
Find the answer in our paper published today in @NatureSMB. Congratulations to Sarah Henrikus & our fantastic lab! 🥳🎉
rdcu.be/dIdI4
Great collaboration with Marta, Allie and John from @DiffleyLab @TheCrick
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Costa Lab retweeted
9 Apr 2024
TWO postdoc positions available in our lab to study ADP-ribosylation and ubiquitylation signalling! We are looking for someone with experience in biochemistry/structural biology/cell biology to work on these exciting projects!
Post 1: DNA damage response my.corehr.com/pls/uoxrecruit…
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11 Apr 2024
Human origin licensing reconstituted with purified proteins. Great collaboration with Florian Weissmann & John @DiffleyLab. A cryo-EM tour de force from our @GreiweJulia.
11 Apr 2024
MCM Double Hexamer Loading Visualised with Human Proteins biorxiv.org/cgi/content/shor… #bioRxiv
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Costa Lab retweeted
19 Jan 2024
I am happy to announce that we've recently posted our new manuscript, titled: ‘Cell Cycle Regulation has Shaped Budding Yeast Replication Origin Structure and Function’ on BioRxiv (biorxiv.org/content/10.1101/…). We hope you enjoy! Tweetorial below:
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Costa Lab retweeted
5 Jan 2024
🌟 Big News! 🌟 the Lewis lab is open for business @MolHorizons. A new chapter of discovery and learning awaits. Thrilled to start this journey and tackle some challenging questions!
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16 Nov 2023
Our study on the cover of Molecular Cell 🥳. Thanks @AgaGambus and @GS_Lab_Bham for a great collaboration.
Structure by Milos Cvetkovic❄️, @PaoloPassaretti🧬, Agata Butryn👩🔬.
Artwork by @petermindek and the nanographics.at team.
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11 Oct 2023
DONSON paper out! Congratulations Milos Cvetkovic and @PaoloPassaretti! Great collaboration with @AgaGambus's group. Thanks @GS_Lab_Bham for contributing.
The structural mechanism of dimeric DONSON in replicative helicase activation: @MolecularCell cell.com/molecular-cell/full…
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The deadline for abstract submissions has been extended to this Sunday (5/21). Share cutting-edge research on RNA and DNA helicases for a short talk or an in-person poster/e-poster. #HNASRC @PaeschkeL @Trakselis @tranforwabash
Register and submit: bit.ly/3McTlQg
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1 Mar 2023
Interested in Structure, Mechanism and Chromosome Biology?
Then you should join our lab at the Crick as a PhD student!
crick.ac.uk/careers-study/va…
Applications close on 22 March 2023.
You might get a hat like Julia's, who successfully defended her thesis last week! 🥳❄️🔬🧬
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14 Nov 2022
Congratulations to our PhD student Julia Greiwe for receiving the Crick Science Achievement Award.
As part of the celebrations, Julia gave a great talk at the Crick Autumn Science Meeting last week.
She described the mechanisms MCM helicase loading and phosphorylation by DDK.
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