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Ivan Ahel Lab @IvanAhelLab
Joined November 2017
  • Tweets 147
  • Following 49
  • Followers 783
2 Photos and videos
The first chemical synthesis of ADP-ribosylated oligonucleotides provides powerful tools to study ADP-ribosylation of nucleic acids pubs.acs.org/doi/10.1021/jac…

Chemical Synthesis of Native ADP-Ribosylated Oligonucleotides Enables Analysis of DNA ADP-Ribosyl...

ADP-ribosylation (ADPr) is a modification by which an ADP-ribose moiety is conjugated to different molecules by ADP-ribosyltransferases (ARTs) to control various cellular processes in organisms from...

pubs.acs.org
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Learn more about the interplay between ADP-ribosylation and ubiquitination: PARG regulates proteasomal degradation of the ADP-ribosyl hydrolase TARG1 by preventing PAR-dependent ubiquitination mediated by the E3 ligases HUWE1 and TRIP12 sciencedirect.com/science/ar…
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The interplay between ADP-ribosylation and ubiquitination, mediated by PARP7 and DTX2 proteins, can serve as a rapid AHR transcription “off-switch” through proteasomal degradation. embopress.org/doi/full/10.10…

Ubiquitin pathway blockade reveals endogenous ADP-ribosylation marking PARP7 and AHR for degradation

The EMBO Journal - ADP-ribosylation is an important protein post-translational modification catalysed by a family of PARP enzymes in humans and is involved in DNA damage and immunity among other...

link.springer.com
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Please check our collaborative paper with Marcin Suskiewicz and Sebastien Huet labs on FAM118 proteins – non-canonical sirtuins that form filaments and act as NADases in human and other vertebrate cells. nature.com/articles/s41594-0…

Filament formation and NAD processing by noncanonical human FAM118 sirtuins

Nature Structural & Molecular Biology - Baretić and Missoury et al. identify vertebrate proteins FAM118B and FAM118A as sirtuins similar to bacterial antiphage enzymes and show that...

nature.com
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Here you can read our full review paper on the interplay between ADP-ribosylation and ubiquitination, with special focus on dual, hybrid modification ADPr-Ub: pubmed.ncbi.nlm.nih.gov/4106…

Interplay between ubiquitination and ADP-ribosylation and the case of dual modification ADPr-Ub -...

Ubiquitination is a fundamental post-translational modification essential for nearly all cellular activities. Traditionally, ubiquitination has been understood as a protein modification, where...

pubmed.ncbi.nlm.nih.gov
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A few years back we discovered a dual hybrid protein modification composed of an ADP-ribose dinucleotide and the ubiquitin moieties (ADPr-Ub). Here you can read our review that will give you an update on this increasingly popular topic: rdcu.be/eETIT
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A few years back we discovered a dual hybrid protein modification composed of ADP-ribose dinucleotide and ubiquitin (ADPr-Ub). Now we reveal that ADPr-Ub can be further ubiquitinated by the E3 ubiquitin ligase RNF114! nature.com/articles/s41467-0…
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The application deadline has been extended for a postdoc position in our lab until August 22. Please enquire/apply if you are interested in ADP-ribosylation, ubiquitination, genome stability or immunity. my.corehr.com/pls/uoxrecruit…
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Ivan Ahel Lab retweeted
YuGeng Zhang@YugengZ
14 Jul 2025
Really thrilled to see our paper out now in @NAR_Open: a new transcriptional repressor, RptR, that regulates type I restriction-modification systems! 🎉 Big thanks to @TangLabOxford, @_MarionSchuller, @IvanAhelLab, and @BlowerLab! doi.org/10.1093/nar/gkaf645

Regulation of a phage defence island by RptR, a novel repressor that controls restriction–modific...

Abstract. Bacteria encode a panoply of defence systems to overcome phage infection. In recent years, over 100 defence systems have been identified, with th

academic.oup.com
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We have another postdoc position available to work on interplay between ADP-ribosylation and ubiquitination in regulation of genome stability. For this post expertise in cell biology is required. my.corehr.com/pls/uoxrecruit…

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Our new paper describing the RNF114 protein as a reader of dual hydrid modification composed of ADP-ribose and ubiquitin (ADPr-Ub) we discovered a few years ago (collaboration with the lab of Gerbrand van der Heden van Noort) biorxiv.org/content/10.1101/…

Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose

Crosstalk between the post-translational modification processes ubiquitination and ADP-ribosylation occurs in DNA-damage and immune-responses, in addition the physical linkage of ADP-ribose and...

biorxiv.org
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A postdoc position is available in our lab to study ADP-ribosylation and ubiquitylation signalling! We are looking for someone with experience in structural biology and biochemistry. The application deadline is June 20th. my.corehr.com/pls/uoxrecruit…
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Ivan Ahel Lab retweeted
Rahul Samant@SamantLab
27 Feb 2025
Call me a #ubiquitin geek, but this is genuinely one of the most exciting findings in recent years. Only came across Ub—ADPr a few years back with some pioneering @IvanAhelLab papers. New field emerging here, folks!
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Our discovery of reversing enzymes for RNA ADP-ribosylation reveals a possible defence protein module against toxic attack pubmed.ncbi.nlm.nih.gov/3997…

Discovery of reversing enzymes for RNA ADP-ribosylation reveals a possible defence module against...

Nucleic acid ADP-ribosylation and its associated enzymes involved in catalysis and hydrolysis are widespread among all kingdoms of life. Yet, its roles in mammalian and bacterial physiology including...

pubmed.ncbi.nlm.nih.gov
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Potential PhD students interested to work in our laboratory are welcome to apply through the ILESLA programme
OxfordEnvRes@OxfordEnvRes
16 Jan 2025
Two weeks to go until the application deadline for ILESLA. If you or anyone you know would benefit from full funding to carry out a PhD in Life and/or Environmental Science please visit/refer to their website iles.web.ox.ac.uk/how-apply where you can see open day videos and guidance
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Ivan Ahel Lab retweeted
ConstantinouLab@ConstantinouL
29 Oct 2024
We are pleased to inform you that the meeting “From Genome Instability to Cancer: A tribute to Angelos Constantinou” that will take place in Carry-Le-Rouet from March 10th to March 13th 2025 is now open for registration on the link: tribute2angelos.fr/page/home…
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Our laboratory is looking for a postdoc with expertise in protein biochemistry and structural biology to work on novel pathways regulated by ADP-ribosylation of nucleic acids. Please RT.
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Our new paper in collaboration with Luca Palazzo laboratory: authors.elsevier.com/sd/arti…

Luca Palazzo@PalazzoLuca
30 Nov 2024
Replying to @PalazzoLuca
Our findings indicate that this synthetic lethal interaction is notably strengthened when paired with alkylating genotoxins. (3)
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Ivan Ahel Lab retweeted
Antonio Ariza@DrAntonioAriza
31 Oct 2024
We're in the news. 😊 @JgmRack @IvanAhelLab @LeidenADPr @physorg_com phys.org/news/2024-10-scient… doi.org/10.1016/j.jbc.2024.1…

Scientists uncover key mechanism in pathogen defense, paving way for new antimicrobial strategies

Researchers have made a significant breakthrough in understanding how certain pathogens defend themselves against the host's immune system.

phys.org
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Ivan Ahel Lab retweeted
Marcin J. Suskiewicz@MSuskiewicz
15 Oct 2024
Our team in Orléans (France) is looking for a new postdoc, to work closely with a research associate, Ibtissam Talhaoui, on a project focused on potential SUMO E3 ligases targeting the nucleosome. The details here: emploi.cnrs.fr/Offres/CDD/UP…
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