We develop plasticity-promoting neurotherapeutics through a combination of chemistry, molecular/cellular biology, and behavioral neuropharmacology.
Joined September 2020
- Tweets 699
- Following 213
- Followers 2,720
- Likes 397
103 Photos and videos
5 Aug 2025
Check out our latest paper in Nature Neuroscience (rdcu.be/ey7yk). This was a great collaboration with some very surprising results! Seems a glutamate burst & proximate IEG expression might not be necessary for structural plasticity induced by 5-HT2A partial agonists.
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14 Apr 2025
I love all of our papers equally, but I might love this one a bit more. Rare to see complex molecule total synthesis, molecular neuroscience, and behavioral neuropharmacology in the same paper! Thanks to everyone who helped make this work possible
pnas.org/doi/10.1073/pnas.24…
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8 Feb 2025
Check out our ibogaine total synthesis in @NatureChemistry! This was a tough project that took nearly a decade to complete by @UCDavisIPN researchers. Includes the synthesis of the unnatural enantiomer of ibogaine and ibogaine analogues that modulate SERT
nature.com/articles/s41557-0…
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Olson Lab retweeted
Exciting new research in @ScienceMagazine
from the labs of IPN researchers @tinakim_neuro @DEOlsonLab reveals that the neural circuitry mediating the anti-anxiety and hallucinogenic effects of #psychedelics are distinct.
@UCDavisCNS
@UCDLandS
@UCDavisMed
science.org/doi/10.1126/scie…
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14 Nov 2024
Check out our latest collaboration in @ScienceMagazine Magazine with @tinakim_neuro's lab, where we re-activate psychedelic-responsive neurons to induce an anxiolytic effect without a head-twitch response.
science.org/doi/10.1126/scie…
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3 Oct 2024
Exciting news! We've launched a crowdfunding campaign for a new art installation in the Chemistry Building! 🎨
Help us raise $5,000 for the amazing artists! Every contribution and share counts. Let’s create something extraordinary! 🙌💙
Join us: shorturl.at/jL8rb
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Olson Lab retweeted
IPN faculty affiliate @tinakim_neuro and team just published in @naturemethods about a protein-based tool expected to aid in identifying how #psychedelics impact brain disorders by tagging neurons activated by psychedelics. nature.com/articles/s41592-0…
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5 Aug 2024
Check out our latest collaboration with Christina Kim's Lab in Nature Methods:
nature.com/articles/s41592-0…
The number of neurons tagged with CaST in the PFC following psilocybin administration correlated with head-twitch response, but the number of cfos tagged neurons did not.
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Olson Lab retweeted
The newest research from IPN Director @DEOlsonLab and team suggests that tropane analogs can promote #neuroplasticity with fewer side effects than compounds like scopolamine. Read more here: pubs.acs.org/doi/10.1021/acs…
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Olson Lab retweeted
Check out the latest IPN paper in J. Med. Chem. on the development of psychoplastogenic DYRK1A inhibitors with potential for treating Alzheimer's disease especially early-onset Alzheimer's disease associated with Down Syndrome
pubs.acs.org/doi/10.1021/acs….
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Olson Lab retweeted
@UCDavisIPN Director @DEOlsonLab talks about psychedelics and nonhallucinogenic psychoplastogens on the @UChicago's Big Brains podcast
news.uchicago.edu/psychedeli…
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Olson Lab retweeted
IPN director @DEOlsonLab was interviewed for this PNAS news feature on the mechanisms of psychedelics
pnas.org/doi/10.1073/pnas.23…
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Olson Lab retweeted
Within #psychedelic science, the debate lingers: Is it mind-blowing experiences or powerful #molecules that spur change? Join @TTBOOK to hear David E. Olson's take. Also available on @Spotify!
youtu.be/JunhDmkrM88?si=OzEE…
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19 Dec 2023
The @UCDavisIPN will be sending out their first newsletter soon. If you are interested in #psychedelics or #neurotherapeutics and would like to receive a copy, please sign up by clicking on the link on this page:
neurotherapeutics.ucdavis.ed…
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6 Dec 2023
Congrats to the Delix team on their positive phase 1 results that they are presenting at ACNP! Also, super excited that Jeff Jonas, former CEO/CIO of Sage Therapeutics, will be joining the Delix SAB!
businesswire.com/news/home/2…
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27 Nov 2023
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9 Nov 2023
article in @TheAtlantic on nonhallucinogenic psychoplastogens:
theatlantic.com/health/archi…
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9 Nov 2023
our latest review covering the effects of psychedelics on neuronal physiology:
annualreviews.org/doi/abs/10…
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2 Nov 2023
great article by @Sara_Reardon in @Nature about the therapeutic mechanisms of #psychedelics
nature.com/articles/d41586-0…
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