Postdoctoral associate at WashU | Jankowsky lab
Joined March 2020
- Tweets 253
- Following 166
- Followers 173
- Likes 463
18 Photos and videos
Pinned Tweet
30 Nov 2024
Connect with me on bluesky! Not leaving X but always looking for new places to learn about #microglia and #neurodegeneration!
140
Jacob M. Dundee, PhD retweeted
Feb 27
I’m happy to be formally selected as the category winner in neuroscience for the 2026 𝗧𝗮𝗸𝗲𝗱𝗮 𝗜𝗻𝗻𝗼𝘃𝗮𝘁𝗼𝗿𝘀 𝗶𝗻 𝗦𝗰𝗶𝗲𝗻𝗰𝗲 𝗔𝘄𝗮𝗿𝗱 𝘄𝗶𝘁𝗵 𝗡𝗮𝘁𝘂𝗿𝗲 @TakedaPharma @Nature, in recognition of my pioneering contributions to 𝗺𝗶𝗰𝗿𝗼𝗴𝗹𝗶𝗮 𝗿𝗲𝗽𝗹𝗮𝗰𝗲𝗺𝗲𝗻𝘁.
nature.com/immersive/innovat…
4
3
62
3,460
Jacob M. Dundee, PhD retweeted
Neuronal subtype governs #amyloid structure, cellular response, and cognitive outcome in genetically targeted APP mouse models
Gabriella A. Perez, Zoe Lai...Joanna L. Jankowsky @bcmhouston @washumedicine #AlzheimersDisease #GABAergic
link.springer.com/article/10…
1
6
544
Jacob M. Dundee, PhD retweeted
25 Aug 2025
Thank you for sharing our microglia replacement study! In 2020, we achieved efficient microglia replacement for the first time (PMID: 32783928). After that, we took another 5 five years to demonstrate its clinical feasibility and efficacy. We truly believe that microglia replacement holds far-reaching potential for treating a wide range of neurological diseases. Let’s change the world and make this happen!
20 Aug 2025
Research Highlight: Microglia replacement halts rare brain disease progression nature.com/articles/s41587-0…
12
45
13,007
24 Aug 2025
I’m thrilled to announce that I have been awarded an @alzassociation grant for my research into the "Functional and transcriptional characterization of TMEM106B in tauopathy". With this funding, I aim to uncover potential roles of TMEM106B in AD and beyond! 👨🔬🔬🧠 #ALZFunded
4
1
22
2,250
Jacob M. Dundee, PhD retweeted
10 May 2025
My recent @NIH Director’s series lecture summarizing 10 years of the lab’s work related to brain drainage and CNS immune surveillance || Navigating Unchartered (Neuroimmune) Waters youtu.be/YWFOhhw-jxA?si=7QV-… via @YouTube
2
24
128
14,761
Jacob M. Dundee, PhD retweeted
9 May 2025
Dear immune/glia lovers of brain, gut and beyond… We’re looking for a lab tech/manager to join our team! Pls see details for application here ucl.ac.uk/work-at-ucl/se… @UKDRI @ucl - pls help circulate among networks who’d be of interest, thank you!
27
46
4,122
Jacob M. Dundee, PhD retweeted
16 Apr 2025
Our lab website is up! We are hiring at all levels.
dolanlab-tcd.com/
4
59
182
31,701
Jacob M. Dundee, PhD retweeted
15 Apr 2025
‼️BIG news ‼️
#ReThinkNeuroimmunology #RTN registration is open and live! The program is amazing!
Hurry up to register while prices are low!
See you in Boston in October! @kipnislab @IdoAmitLab @QuintanaLabHMS @stevens1lab @RejaneRua
genelayinstitute.org/rtn/
60
70
5,141
Jacob M. Dundee, PhD retweeted
10 Apr 2025
Thrilled to share my latest paper in @MolNeuro where we demonstrate that the knock-down of GPNMB via ASOs in myeloid cells from preclinical models and FTD-GRN patients perturbs lysosomal function and increases immune responses 1/5 🧵
bit.ly/3Ed5ULn
1
2
8
628
Jacob M. Dundee, PhD retweeted
📢 New webinar coming soon 📢
Prof. Steffen Jung from @WeizmannScience will be our next speaker on April 1st. Check all the information in the flyer and add it to your calendar!
6
20
978
Jacob M. Dundee, PhD retweeted
13 Mar 2025
The program is now finalized for the 2nd annual Hans J. Müller-Eberhard Symposium on Neuroimmunology and Glial Biology! The event will be held @CNG_UTHealth at Institute of Molecular Medicine @McGovernMed @UTHealthHouston. Thanks all committed speakers and sponsors! Stay tuned!
21
72
5,668
Jacob M. Dundee, PhD retweeted
6 Mar 2025
Our new paper is in print form: Human longevity and Alzheimer’s disease variants act via microglia and oligodendrocyte gene networks 1/ academic.oup.com/brain/artic…
3
25
101
5,198
Jacob M. Dundee, PhD retweeted
22 Jan 2025
'#APOE Christchurch enhances a disease-associated #microglial response to #plaque but suppresses response to tau pathology'
Kristine M. Tran, Nellie E. Kwang...Grant R. MacGregor & Kim N. Green @UCIrvine @UCIBioSci #AlzheimersDisease
bit.ly/4h7SUoG
17
47
3,476
Amyloid strengthens synaptic connections between regions loaded with neurofibrillary tangles, fueling the propagation of tauopathy in AD. @LMU_Muenchen ow.ly/Ynzo50UMfg7
4
18
2,162
The #SynpaticPruningDebate rages on with an impressive level of LIVE IMAGING support from this work (albeit in co-culture). An unique documentation of microglial surveillance in culture (the best to date?!) What a beautiful study @ryuta_koyama!!!!! 🤯🤩👏🏾nature.com/articles/s41467-0…
2
9
51
4,426
Jacob M. Dundee, PhD retweeted
20 Jan 2025
Are you using 5xFAD mice to study Alzheimer’s disease? Our work @NeuroCellPress may be relevant to you 🐁 Age and sex are known to influence Aβ plaque burden in these mice. Here, we found that the transgene parentage is another strong determinant. (1/11)
cell.com/neuron/fulltext/S08…
5
49
180
22,637
Jacob M. Dundee, PhD retweeted
19 Jan 2025
Microglia lovers listen....
nature.com/articles/s41467-0…
45
164
11,401
Inhaled xenon shifts microglia into a phagocytic state, suppressing amyloidosis in mouse models. A Phase 1 trial has started. #alzheimersdisease @BrighamWomens @wustl ow.ly/s1xO50UIEvj
2
11
1,359
Jacob M. Dundee, PhD retweeted
16 Jan 2025
My first post is my first first author publication 😊 Thank you to all those who made this possible!
Check it out: I demonstrate the impact of Neu1-mediated de-sialylation of Trem2 on microglia function and cellular state. cell.com/cell-reports/fullte…
2
8
1,520
Jacob M. Dundee, PhD retweeted
14 Jan 2025
So great to see our cover on the new @ImmunityCP issue! Kudos to the artistic touch of @Ales_matera ☺️ with @AnneCompagnion and the many collaborators! read more about microglia and Inpp5d (SHIP1) in brain development
14 Jan 2025
New issue online! Cover depicts work from @rosa_paolicelli @Ales_matera @AnneCompagnion &co showing that Inpp5d (SHIP1) is expressed in microglia during early postnatal brain development, where it limits synaptic pruning in a complement-dependent manner. Cover shows microglial cells (magenta) interacting with neurons (cyan) in the mouse CA1 hippocampal region during early development cell.com/immunity/issue?pii=…
14
15
109
7,573