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The Dénes Lab @DenesLab
Joined September 2018
  • Tweets 58
  • Following 193
  • Followers 442
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Let's kick off with this week with #microglia: in our latest @NatureComms paper, we show how microglia fundamentally influence neuronal properties in ex vivo acute slices nature.com/articles/s41467-0…

Microglia contribute to neuronal synchrony despite endogenous ATP-related phenotypic transformation...

Nature Communications - Microglia undergo rapid phenotype changes in response to tissue disturbances but the impact of these changes on neuronal networks is unclear. Here, the authors show that...

nature.com
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The Dénes Lab retweeted
Balazs Hangya@balazs_hangya
7 Jun 2024
Out now in @natcomms : parvalbumin-expressing neurons of the diagonal band of Broca mediate learning from negative experiences rdcu.be/dJ9ek Congratulations Panna Hegedüs, @kiraly_b, Dániel Schlingloff!
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The Dénes Lab retweeted
Balazs Posfai@BalazsPosfai
2 Feb 2023
Adam is just about to flood us with information about compartment-specific neuronal and vascular modulation by #microglia at the #FENS-Hertie Winter School @FENSorg @DenesLab
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We are happy to share the newest results of our lab elaborating on the essential role of somatic junctions during development. Paper now now out in @CellReports doi.org/10.1016/j.celrep.202… Brief summary: eurekalert.org/news-releases…

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The Dénes Lab retweeted
bioRxiv Neuroscience@biorxiv_neursci
15 Apr 2022
Rapid microglial phenotype changes modulate neuronal networks and sharp wave-ripple activity in acute slice preparations biorxiv.org/cgi/content/shor… #biorxiv_neursci
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The Dénes Lab retweeted
Arthur Liesz@ArthurLiesz
12 Mar 2022
We conclude a wonderful @EMBO Stroke-Immunology Workshop in Munich! Many thanks to all the speakers and participants for their contributions and discussions.
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Our new paper by Császár, Lénárt et al., is out in @JExpMed showing that #microglia modulate cerebral blood flow, neurovascular coupling and adaptation to hypoperfusion via dynamic, purinergic actions in the #NVU. rupress.org/jem/article/219/…
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New paper out in @PLOSBiology elaborating on the importance of the NKCC1 transporter in microglial physiology and inflammatory responses. Central vs systemic blockade of NKCC1 with bumetanide have opposite effects. Great team effort led by @KrisztinaTth6 journals.plos.org/plosbiolog…

The NKCC1 ion transporter modulates microglial phenotype and inflammatory response to brain injury...

This study shows that inflammatory responses of microglial cells are markedly influenced by the ion transporter, NKCC1; blockade or genetic deletion of microglial NKCC1 has broad cell-autonomous...

journals.plos.org
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Many thanks to all speakers and participants who contributed to the Stroke-Immunology meeting. Great talks, inspiring data, stimulating discussions - see you all next year!
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The Dénes Lab retweeted
Balazs Posfai@BalazsPosfai
2 Dec 2020
I am very happy to share this piece of review from @Deneslab, @csaba_cserep and me with all microglia-enthusiasts! cell.com/neuron/fulltext/S08… @NeuroCellPress #microglia
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Huge success! Our paper on somatic microglia-neuron junctions has been honored with the annual Outstanding Paper Award from @eurmicsoc Join us in congratulating all the authors! science.sciencemag.org/conte…

ALT Celebrate Happy GIF

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A brilliant piece of perspective from Axel Nimmerjahn on microglia-neuron somatic junctions science.sciencemag.org/conte… Also, our paper reached its final form: science.sciencemag.org/conte…
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Some of our latest results are included in this newly released paper: Microglia alter the threshold of spreading depolarization and related potassium uptake in the mouse brain journals.sagepub.com/doi/ful… We really enjoyed working together, and huge congratulations @DanielP_Varga

Microglia alter the threshold of spreading depolarization and related potassium uptake in the mouse...

Selective elimination of microglia from the brain was shown to dysregulate neuronal Ca2 signaling and to reduce the incidence of spreading depolarization (SD) ...

journals.sagepub.com
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The Dénes Lab retweeted
Arthur Liesz@ArthurLiesz
30 Dec 2019
New paper out: we show that microbial short-chain fatty acids improve neuroplasticity and functional recovery after stroke. Effect is mediated by brain-invading T cells on microglia. jneurosci.org/content/early/… @rebeccaksadler @SfNJournals @JNeuroscience
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The Dénes Lab retweeted
Alzforum@alzforum
14 Dec 2019
To monitor neurons, microglia keep tabs on the soma. ow.ly/x3O150xzWK3
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Our paper has been picked by @sciencemagazine for first release! Microglia monitor and protect neuronal function via specialized somatic purinergic junctions science.sciencemag.org/conte… We are extremely grateful for the hard work and utmost help of everybody involved!
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@csaba_cserep @BalazsPosfai @BekyBlack @st_heindl @KrisztinaTth6 @ArthurLiesz @LieszLab
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The Dénes Lab retweeted
Arthur Liesz@ArthurLiesz
29 Oct 2019
Today is #WorldStrokeDay ! Stroke is the second leading cause of death. 1 of 4 of us will have a stroke! Besides better prevention, we must increase our efforts for a better mechanistic understanding of this disease and develop novel therapies @ISD_Research
European Stroke Org@ESOstroke
29 Oct 2019
Today we lend our voice to #WorldStrokeDay ow.ly/ENYy50wVLxv #DontBeTheOne #ESOWSO2020
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The Dénes Lab retweeted
Stefan Roth@StefanRoth86
8 Jul 2019
I want express my sincere gratitude to the organizers and program committee of @brain_2019, to @ISD_Research @LieszLab and all the kind congratulators for being honored with the Niels Lassen Award!
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From our lab we had two beautiful study presented by @BekyBlack @csaszar_eszter at the Brain meeting in Yokohama. Expect to hear more at the first stroke immunology meeting next year in Münich!
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