For medical information, general AI frontier models (Google, OpenAI, Anthropic) outperformed specialized @EvidenceOpen and @UpToDate as assessed by 12 US clinicians, randomized and blinded to which model and extensive testing/benchmarks. This was not anticipated. @NatureMedicine nature.com/articles/s41591-0…

Elon just created 4,400 millionaires in a single day. 400 of them are now worth over $100 million. These aren't VCs. They're SpaceX employees, and the list includes welders, technicians, and cafeteria staff, because for two decades the company paid every level of the workforce in stock instead of higher salaries. Juan Hernandez immigrated from Mexico and took a $28 an hour contractor welding job in 2015. He says he didn't even know what SpaceX was. The company gave him a $10,000 equity grant and let him buy more shares through payroll deductions. That stake is now worth $880,000. Trevor Hise's parents wanted him to take a stable job at General Electric. He picked SpaceX instead, stayed 12 years, and accumulated over 100,000 shares. At the $135 listing price that's $13.5 million. He's 37 and semiretired. His words: "The magnitude of this has been ridiculous." The most telling detail came before the listing. Over 100 employees quietly banded together and negotiated a group wealth management deal covering up to $5 billion, because none of them had ever needed a wealth manager before. Software IPOs have minted millionaires for 30 years. This is the first one where the money went to the factory floor.

Chemo can't tell a cancer cell from a healthy one. That's the entire side-effect problem. Nobel Prize winner Dr. Jennifer Doudna's lab just built something that can. It reads the cell's RNA, and if it finds the message for mutant p53, the single most common typo in cancer, it triggers a CRISPR enzyme to shred that cell's DNA. One wrong letter is the trigger. Healthy cells, spared. The killing works. In mice, a single dose roughly halved the tumors. The unsolved half is getting it into every tumor cell in a living body. That's where every CRISPR cancer idea has stalled. Real advance, real wall.

अच्छी ज़िन्दगी जीने के बस दो ही तरीके हैं- एक जो पसंद है उसे हासिल कर लो, या जो हासिल है उसे पसंद करना सीख लो।

THANK YOU DAVID FOR THE LESSON! 🥹❤️ Life is full of lessons. Last week, on a flight from Goa to Mumbai, I learned one. In the picture is David. When David boarded the flight, many people looked at him because he was overweight. He came and sat across the aisle from me. In the middle of the flight, he opened his bag, took out a huge collection of chocolates and sweets, and then walked towards the washroom. I exchanged a glance with the gentleman sitting next to him and said, “He shouldn’t eat so much sweets and chocolates!” This was said out of concern! The gentleman smiled and replied, “Well, that’s probably why he looks the way he does.” A little while later, David came back, gathered all the sweets, and handed them over to the cabin crew. 🥹 I was surprised. So I told him, “I must confess, I thought you were going to eat all those chocolates yourself, and that’s why you were overweight.” He smiled and said, “ I don’t blame you for thinking like that! I have a medical condition. But I used to work with airlines, and I know what cabin crew members go through every day. So I like to bring them something sweet whenever I travel.” What an outstanding human being. And what a lesson for me. How quickly we judge people. How easily we create stories about them without knowing anything about their lives.😳 Thank you, David, for reminding me that kindness is often hidden behind appearances, and that the best people are sometimes the ones we understand the least. I asked him for a pic! He obliged! Thank you for the lesson my friend!❤️ #LifeLessons #Encounters

World Number 1 from India ! Congratulations Srishti Kiran 👏🏼👏🏼👏🏼

History created! Cleveland Clinic (Ohio, USA) is coming to Maharashtra (India) ! Extremely elated to share that Govt of Maharashtra signs MoU with the Cleveland Clinic, Brookfield Asset Management and Arodhan Health City to develop Navi Mumbai International MediCity (NMIMC)—a first-of-its-kind global healthcare, research and innovation ecosystem for India. With a global investment of USD 1.2 billion, creating 10,000 jobs, Spread over 250 acre and with Cleveland Clinic as our anchor partner, we are creating a platform that will combine world-class patient care, medical education, research, AI, genomics and innovation at an unprecedented scale. Witnessed this historic MOU signing in the presence of Cleveland Clinic CEO Dr. Tomislav Mihaljevic, Dr. Sameer Kapadia (Chairman of Cardiovascular Medicine), Board Member Lakshmi Mittal ji (Executive Chairman Arcelor Mittal), & Dr. Falcone (President, Emerging Markets) from Ohio, USA, and officials from all organisations. This is more than just a healthcare project. In line with the ‘Heal in India’ vision set by our Hon PM Narendra Modi ji, this is our bold step towards making India a global destination for healthcare, research and medical innovation. Launching this on such a momentous day as our beloved Hon PM Modi Ji creates a record of 4399 days — #LongestServingElectedPMModi makes it even more historic! Many congratulations to Maharashtra & Bharat for this great beginning! Thank you Cleveland for partnering with us; together we shall create healing wonders ! @ClevelandClinic @Brookfield @ArcelorMittal @IndiainNewYork @IndianEmbassyUS

The widespread adaptation of #GLP1 drugs is hampered primarily by their gastro-intestinal side effects. Exciting advances in the field continue to happen, but there's little progress in reducing the non-serious, transient but common, troublesome stomach related side effects in the initial stages of drug use. Unless we crack that- a difficult task given the mode of action of #GLP1- discontinuation rates will continue to be high, posing a challenge to long term use/subsequent systemic benefits of these molecules. The two most significant advances in GLP1 field over the last few weeks have been 1. The data on #Retatrutide which surpasses weight loss efficacy of #Tirzepatide #Mounjaro 2. Early data on muscle preserving drugs used with #GLP1 medication indiatoday.in/health/story/a…

You have noticed it. ChatGPT feels dumber than it used to. Your prompts that worked six months ago produce worse results now. The writing sounds flatter. The ideas sound safer. The internet itself feels like it is shrinking. Every article reads the same. Every email sounds the same. Every answer sounds like it was written by the same voice. You thought it was you. It is not you. Researchers at Oxford and Cambridge published a paper in Nature proving what is happening. They call it Model Collapse. Here is the mechanism in one sentence. AI trained on AI-generated data gets dumber every generation until it forgets what real human data looked like. The internet is filling with AI-generated content. Blog posts. Articles. Reviews. Comments. Social media. AI companies scrape the internet to train the next generation of models. Which means the next generation of AI is being trained on the output of the current generation. Each cycle loses information. Not randomly. It loses the rarest, most unusual, most creative parts first. The researchers call these the "tails of the distribution." The weird ideas. The unexpected perspectives. The things that made the internet feel human. Those disappear first. What remains is the average. The safe. The expected. The bland. Then the next generation trains on that. And loses more. And the next generation trains on that. And loses more. The researchers proved this is not a slow decline. Major degradation happens within just a few iterations. Even when some of the original human data is preserved. They tested it on large language models. On image generators. On statistical models. The pattern was the same every time. The output converges toward a narrow, flattened version of reality that looks nothing like the original data. The lead researcher put it plainly. "Large language models are like fire. A useful tool. But one that pollutes the environment." The pollution is invisible. You cannot see which sentence on the internet was written by a human and which was written by AI. Neither can the AI that is about to train on it. And once the tails are gone, they do not come back. The damage is irreversible. This is not a prediction anymore. It is a diagnosis. The internet you grew up on was built by humans writing things no algorithm would have written. Strange, personal, imperfect, alive. That internet is being diluted. One generation of AI at a time. And the models trained on what remains are learning a smaller and smaller version of the world. Model Collapse is not a technical problem. It is a cultural one. The thing that made the internet worth reading is the thing that disappears first.

Alexander Zverev's journey to Grand Slam glory is a story of resilience, perseverance, and determination. Diagnosed with Type 1 diabetes at the age of four and managing the condition with daily insulin, Zverev has spent his entire life overcoming challenges both on and off the court. Today, at 29, he has achieved one of tennis' greatest milestones by becoming a Grand Slam champion. Zverev defeated Flavio Cobolli in a demanding five-set French Open final to capture the biggest title of his career and end years of heartbreak in major tournaments. His triumph also ends a long wait for a German men's Grand Slam singles champion and serves as an inspiration to millions of children living with diabetes around the world. #AlexanderZverev #frenchopen