@DumontLab profile picture
Sophie Dumont @DumontLab

Mechanics of cell division @UCSF

Joined May 2015
  • Tweets 279
  • Following 1,598
  • Followers 2,673
30 Photos and videos
Excited to share our work out in @CurrentBiology today! We find that NuMA acts as a spindle "glue" - independent of its partner dynein. Congrats to student Nathan Cho who led the work, and thanks to Merve, Aryan and @Yildiz_Lab for in vitro help. cell.com/current-biology/ful…

NuMA mechanically reinforces the spindle independently of its partner dynein

Cho et al. show that NuMA plays a dynein-independent role during mitosis, passively reinforcing spindle poles. NuMA’s length and self-interactions are important for its ability to protect spindle...

cell.com
1
9
38
2,171
Excited to share NuMA preprint #2/2! We report structural and functional insights into how NuMA activates and regulates dynein at cell division. Congrats to Merve Aslan @Yildiz_Lab, @AmicoEnnio @Carter_Lab and Nathan Cho from our lab. And others inc. Maddie Blaauw from our lab. biorxiv.org/content/10.1101/…
4
9
1,093
Excited to share NuMA preprint #1/2! We find that NuMA mechanically reinforces the spindle independently of its partner dynein. Congrats to student Nathan Cho who led the work, with Merve Aslan and @Yildiz_Lab. biorxiv.org/content/10.1101/…

NuMA mechanically reinforces the spindle independently of its partner dynein

Both motor and non-motor proteins organize microtubules to build the spindle and maintain it against opposing forces. NuMA, a long microtubule binding protein, is essential to spindle structure and...

biorxiv.org
4
19
1,403
Congrats to Alexandra Long @alexandraflong, the second student from our lab to start their own lab! Her lab is in Univ. Kentucky's Biology Dept, studying the evolutionary cell biology & biophysics of cellular organization. Check it out! alonglab.org

Long Research Group

Long Research Group - Univ. Kentucky

alonglab.org
1
2
13
1,546
Alex was a postdoc with Tim @StearnsLab & Jessica Feldman
1
3
825
Excited to share our work out in @CurrentBiology ! We find that SKAP's binding to microtubules *reduces* friction at the kinetochore-microtubule interface and increases attachment stability under force. Congrats to postdoc Miquel @RosasSalvans and all authors! With @Caleb_J_Rux and Moumita Das. sciencedirect.com/science/ar…

1
10
27
2,005
Nominate a colleague or yourself for the Motility and Cytoskeleton Early Career Award at the 2025 Biophysical Society Meeting! To do so fill out this form and email Radhika Subramanian and I your CVs by Dec 1 2024: docs.google.com/forms/d/e/1F…

Motility and Cytoskeleton Early Career Award Nomination

We are soliciting nominations for the Biophysical Society's Motility and Cytoskeleton Subgroup Early Career Award which will be awarded at the subgroup session in February 2025. The Early Career...

docs.google.com
20
28
7,938
Congrats to Christina Hueschen @clhueschen, the first student from our lab to start their own lab! Her lab is in UCSD's Cell & Dev Bio Dept, studying the physical biology of parasites. Can't wait to see what science they do. Check it out! hueschenlab.biosci.ucsd.edu/

5
6
81
4,937
Christina was a postdoc with Alex Dunn @Dunn_Lab. And wrote a book with Rob Phillips, The Restless Cell: Continuum Theories of Living Matter. Wow ...
1
7
1,545
Excited to share a preprint! We find that SKAP's binding to microtubules *reduces* friction at the kinetochore-microtubule interface and increases attachment stability under force. Congrats to postdoc Miquel @RosasSalvans and all authors! With @Caleb_J_Rux and Moumita Das. biorxiv.org/content/10.1101/…

1
6
19
2,877
With this work we are sad to say goodbye to postdoc Miquel @RosasSalvans who is returning to Barcelona. We will miss Miquel's intellect, generous spirit, and all the fun times doing science together. Best of luck!
1
8
1,493
Nominate a colleague or yourself to speak at the Motility & Cytoskeleton Subgroup at the 2025 Biophysical Society Meeting! Radhika Subramanian and I are organizing the subgroup and looking for nominations by July 8th: forms.gle/i3AMosmEugx2cnfn8.

Motility and Cytoskeleton Subgroup: Speaker Nomination

We are soliciting nominations for speakers for the Motility and Cytoskeleton Subgroup session at the 2025 Biophysical Society meeting. Nominees should be individuals who have not spoken at the BPS...

docs.google.com
1
13
27
5,381
Excited to share our work @JCellBiol! We find that torques within and outside the spindle oppose each other to limit spindle twist during anaphase. Congrats to @LilaNeahring who led the work! Thanks to Nathan Cho, @Caleb_J_Rux, @Yildiz_Lab, Upadhyayula and Subramanian Labs. rupress.org/jcb/article/223/…

1
8
47
4,255
Excited to share our work @JCellBiol! We find that chromosome size-dependent spindle forces impair mammalian mitotic error correction of long chromosomes. Congrats to graduate student @megan_chong who led this work! With Miquel @RosasSalvans @VannaTran5 rupress.org/jcb/article/223/…

Chromosome size-dependent polar ejection force impairs mammalian mitotic error correction

Chong et al. show that chromosomes biorient and correct errors with varying efficiencies. Chromosome size and the spindle forces that scale with size deter

rupress.org
3
28
100
13,265
Excited to share our work out in @PLOSONE with @goga_lab showing that expressing an oncogene protects spindle poles from fracturing in mechanically confined environments. Congrats to first authors @RenaldoSutanto and @LilaNeahring and all authors! journals.plos.org/plosone/ar…

The oncogene cyclin D1 promotes bipolar spindle integrity under compressive force

The mitotic spindle is the bipolar, microtubule-based structure that segregates chromosomes at each cell division. Aberrant spindles are frequently observed in cancer cells, but how oncogenic...

journals.plos.org
1
9
45
4,347
Congratulations to graduate student @megan_chong from our lab who received a UCSF Dean’s Award for Excellence in Mentoring! Megan is an inspiring mentor to many in our lab and out. And congrats to all other awardees! @UCSFGradDiv
1
6
62
3,848
Excited to share a preprint! We find that torques within and outside the human spindle oppose each other to limit spindle twist during chromosome segregation. Congrats to @LilaNeahring who led the work! biorxiv.org/content/10.1101/…

Torques within and outside the human spindle balance twist at anaphase

At each cell division, nanometer-scale motors and microtubules give rise to the micron-scale spindle. Many mitotic motors step helically around microtubules in vitro, and most are predicted to twist...

biorxiv.org
1
8
50
4,858
Thanks to Nathan Cho, @Caleb_J_Rux and collaborators @Yildiz_Lab, Upadhyayula and Subramanian Labs!
2
646
Lab dinner with past and present lab members at #CellBio2023 😊
1
2
59
4,919
Our lab is exicted to be at @ASCBiology #cellbio2023 in Boston. Come check out what we've been up to! @c3STC
5
43
5,582
Load more