doi.org/10.1111/nph.20071 Thanks @Jenny_Mortimer1 and Henrik Scheller for the insightful commentary on our recent work in @NewPhyt. We identified the missing ArapTs and GalTs for plant xylan synthesis. Bacteria may be adapting their GH30 xylanases to cleave these xylan structures!
Congratulations to Wout and John! Their great research on plant cell walls, especially lignin synthesis and diversity of structure, is recognised with this prestigious prize
The @SupplantCompany, which started in the Department and works closely with @DupreeLab,
has launched its revolutionary new pasta in the UK in the dining halls of Magdalene College (@magdalenealumni). It is healthier and better for the planet, more here: supplant.com/products
Paul Dupree has been awarded a £1-million @innovateuk grant to work with the @SupplantCompany. The award enables the @DupreeLab to use their ground-breaking research to support the development of Supplant's healthier alternatives to sugar and starch: bioc.cam.ac.uk/news/dupree-g…
Plant cell wall glycosyltransferases underpin the complex structure of dietary fibre. In our new work doi.org/10.1111/nph.19305, we show that β-xylosylated xyloglucan arose from the rapidly evolving GT47 family, while a promiscuous GH43 hydrolase permits its digestion in the gut.
📢Prof. Steven Brown has been awarded £17M with consortium partners to procure the UK's most powerful Nuclear Magnetic Resonance (NMR) instrument at 1.2GHz. @NrfHf
Funded by @EPSRC, the national facility will enable applications from batteries to pharmaceuticals.
Find out more⬇️
Our unexpected discovery will change views on plant cell wall composition and architecture! The structure of primary cell wall polysaccharides seems to be very important for plants! #glycotime
Congratulations to @H_TempleS and @KI55141505 (Konan) for winning best postdoc talk and best PhD poster presentation at the IX Cell Wall Research Conference #glycotime
Our work discovering putative Golgi SAM transporters is now out in @NaturePlants! rdcu.be/cPjUa Using solid state NMR with @MeiHongLab we found egg box pectin structures in the plant cell wall. Egg box formation is influenced by methylation status! #glycotime
Our work discovering putative Golgi SAM transporters is now out in @NaturePlants! rdcu.be/cPjUa Using solid state NMR with @MeiHongLab we found egg box pectin structures in the plant cell wall. Egg box formation is influenced by methylation status! #glycotime
New Article: "Golgi-localized putative S-adenosyl methionine transporters required for plant cell wall polysaccharide methylation" rdcu.be/cPkfB
Methylation occurs in the Golgi and relies on the import of SAM molecules into the Golgi lumen by transporters.
We’re thrilled that our work on EXTL3 is finally out in @NatureComms! The structure is a first for Golgi bi-domain GTs and the GT47 family. There are discoveries on plant GT47s too: a putative UDP-binding motif and a new subclade in lower plants rdcu.be/cPfHm#glycotime
6/7 Consistent with these features, and despite the presence of 10 mM UDP, we were unable to find density for UDP in the GT47 domain. The GT64 domain, however, binds UDP identically to murine EXTL2.
7/7 In plants, GT47 enzymes are vital for cell wall synthesis. Our phylogenies show that many non-angiosperms possess additional GT47s that are closely related to animal EXTs. However, the fusion with GT64 appears to have arisen only at the outset of metazoan evolution.