DNA repair and Gene Expression in human disease. Andalusian research group. Find us at @IBiS_Sevilla
Joined May 2016
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Pinned Tweet
1 Dec 2025
New manuscript from the lab on @cddpress " H263A and SCAN1/H493R mutant TDP1 block TOP1-induced Double-Strand Break Repair during gene transcription in quiescent cells and promote cell death". rdcu.be/eSxtG @ibis_sevilla @InvestigaUS
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Fernando Gomez-Herreros Lab retweeted
Thrilled to share our latest preprint biorxiv.org/content/10.64898…. In this study, we identified EXO1 as a clinically relevant, targetable candidate in Ewing sarcoma.
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Very excited to announce the workshop "DNA–Protein Crosslinks: Mechanisms and Links to Rare Genetic Disorders", which will take place in Baeza (Spain) from 18–20 November 2026! unia.es/estudios-y-acceso/of…
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Muy contentos y agradecidos de que el último trabajo del laboratorio haya sido seleccionado como artículo del mes por la @SEBBM_es !!🎉🎉 @ibis_sevilla @InvestigaUS
#ArtículodelMes
H263A and SCAN1/H493R mutant TDP1 block TOP1-induced double-strand break repair during gene transcription in quiescent cells and promote cell death
Por @Diana_Rubio_ et al.
f.mtr.cool/cybufwyhmj
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Fernando Gomez-Herreros Lab retweeted
Our Science paper is out! 😀 Enjoy if you like SPRTN, DPCs, Innate immunity and Aging.
science.org/doi/10.1126/scie…
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Fernando Gomez-Herreros Lab retweeted
1 Dec 2025
Excited to see our research published!! 🎉
Amazing project in @FGH_Lab at @ibis_sevilla, @unisevilla
"H263A and SCAN1/H493R mutant TDP1 block TOP1-induced double-strand break repair during gene transcription in quiescent cells and promote cell death"
nature.com/articles/s41419-0…
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1 Dec 2025
New manuscript from the lab on @cddpress " H263A and SCAN1/H493R mutant TDP1 block TOP1-induced Double-Strand Break Repair during gene transcription in quiescent cells and promote cell death". rdcu.be/eSxtG @ibis_sevilla @InvestigaUS
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1 Dec 2025
These results support the potential role of TOP1-induced DSBs as a main contributor to certain hereditary neurological syndromes.
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1 Dec 2025
A terrific work of @diana_rubio and @hidalgogarciaD with the support of all the lab. @josefra1975 @E__GranadoCalle
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Fernando Gomez-Herreros Lab retweeted
28 Aug 2025
Un estudio del Instituto de Biomedicina de Sevilla desvela un nuevo mecanismo de sensibilidad del sarcoma de Ewing a la quimioterapia #Sevilla #SevillaHoy ddsevilla.info/rbr9b1
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29 Jul 2025
Our latest study is now online at @oncogenejournal pubmed.ncbi.nlm.nih.gov/4072… A great collaboration between the @FGH_Lab and @LabHuvr labs, driven by the outstanding work of @olmedo_pelayoJ at @ibis_sevilla Check it out!
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29 Jul 2025
👉EWS::FLI1 modulates R-loop metabolism via DHX9, driving increased vulnerability to TOP1-targeting agents.
👉Targeting TOP1 in EWS cells destabilizes the genome and provokes strong replication stress and cell death in EwS cells and tumors
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29 Jul 2025
Grateful to all collaborators who made this work possible!
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Fernando Gomez-Herreros Lab retweeted
14 Apr 2025
Proud to announce that last Thursday I successfully defended my PhD thesis, “Understanding genome instability in Ewing sarcoma: from molecular mechanisms to novel therapeutic approaches”, at the @ibis_sevilla.
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Fernando Gomez-Herreros Lab retweeted
30 Mar 2025
📢 For all DNA fiber enthusiasts! 🟥🟩 We are thrilled to announce the release of our long-awaited AI-based workflow for the automated and quantitative analysis of DNA fibers. It's an exciting step forward—check it out on bioRxiv! lnkd.in/dQWUPtsP
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Fernando Gomez-Herreros Lab retweeted
27 Mar 2025
Thrilled to share our latest work. Great collab with Costanzo, Masson, Freire and Reyes' labs.
HMCES corrupts replication fork stability during base excision repair in homologous recombination–deficient cells | Science Advances science.org/doi/10.1126/scia…
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Fernando Gomez-Herreros Lab retweeted
14 Mar 2025
Se ha filtrado el borrador de ley de universidades que está preparando la CAM. Si se aprueba, será la muerte de la universidad pública madrileña. Es escandaloso. No exagero. Se vienen tiempos oscuros como no espabilemos. Explico algunos puntos críticos. Va hilo. 👇
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Fernando Gomez-Herreros Lab retweeted
4 Mar 2025
¡¡Premio Nacional de Juventud en Ciencia y Tecnología!! Gracias @InjuveSpain y @JuventudInfGob por dar visibilidad y reconocer la labor de los jóvenes investigadores en España. @ibis_sevilla @FISEVI_sevilla @FGH_Lab @InvestigaUS
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Fernando Gomez-Herreros Lab retweeted
17 Jan 2025
Have a look at our review in @MolecularCell . We explore how histone modifications serve as integrators of genome activity, mediating communication between distinct DNA procesess. authors.elsevier.com/a/1kS2f…
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Fernando Gomez-Herreros Lab retweeted
20 Jan 2025
Dynamic histone modification patterns coordinating DNA processes dlvr.it/THSzk5
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