Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration biorxiv.org/content/10.1101/…

Check out our latest @Bims_BiomedNews report on Mitochondrial Bioenergetics and Cancer - biomed.news/bims-mibica/2023… Lab pick in @eLife - Mitochondrial run HOT!! 🔥 - elifesciences.org/articles/8…

Last update for 2023: Database of PhD fellowships and funding opportunities. For each of the 190 fellowships, we provide description, link to funder, $ amount, deadline, and eligibility criteria (e.g. citizenship, green card, etc) Download it here: research.jhu.edu/rdt/funding…

IMF Report on the significant economic return of investment in basic research. "We find that basic scientific research affects more sectors, in more countries and for a longer time than applied research (commercially oriented R&D by firms)" See it here: imf.org/en/Blogs/Articles/20…

Wondering if you should get your baby the new RSV shot? I’ve studied respiratory viruses like RSV, and their vaccines and treatments for years Here’s a 🧵 of key info We just had a baby last week We chose to protect our newborn with it And we’re lucky we could get a dose 1/

Energy flow in the mouse brain

Job Alert! The MPRC is looking to recruit a postdoctoral fellow to help define how a mitochondrial protein is degraded outside of this organelle! Work on a grant while building your own project for your future lab! Retweets appreciated! Email if interested: sclaypo1@jhmi.edu

Today's Nobel is a reminder to focus on the work and not the journal. The key publications cited by the committee were published in Immunity, Molecular Therapy, and Nucleic Acids Research. Respectable journals, but not the Big 3. The discoveries are what's important, not a name.

Defective metabolic flexibility in a monogenic form of #Autism spectrum disorder? See our recent work doi.org/10.1093/hmg/ddad154 Inspired by @ChrisPalmerMD, @MitoPsychoBio, @RSRT, and many others

Exciting updates for users of BrainRNAseq.org ! The site may look the same at first glance, but it has been completely rebuilt from the ground up with important features!

This #EM_Monday I want to put the word out that I will be on job market this year! As you might have noticed, I am fascinated by the shapes of various organelles that become drastically different in specialized cells. And I want to know how and why?! The most notable…(1/5)

Such a fun visit to my alma mater (@neurophd_emory 2002-2007). How time flies! 😊 Thank you @FaundezLab @acorbe2 and the IMSD program @IMSDEmory!

Identification of ligand–receptor pairs that drive human #astrocyte development New from @avoss2022@SamLanj@Sloan_Lab@EmoryUniversity nature.com/articles/s41593-0…

The courage of this woman scientist standing up for herself and for what's right reminds me of what Jennifer Doudna said when asked, by a female student, for career advice: "Walk into every room like you OWN THE PLACE." BRAVA! to this person and all #WomenInSTEM for doing so.

Wow. Justice Ketanji Brown Jackson dissent.

TransitID is out today in Cell! This is a proximity labeling method for unbiased discovery of endogenous proteins that traffick from a defined “source” location to a defined “destination” location. TransitID uses sequential labeling by TurboID in the source, followed by a chase period (minutes to hours) and then 1-minute APEX tagging in the destination compartment. Proteins tagged by both enzymes are enriched with streptavidin and anti-fluorescein antibody, and identified by mass spec. We explore 4 intracellular and intercellular applications of TransitID: - discovery of locally translated mitochondrial proteins (translated at OMM, then imported into mito matrix) - mapping proteins whose cytoplasm-to-nucleus shuttling is dampened by stress - discovery of proteins that transit between nucleolus & stress granules during stress & stress recovery - analysis of proteins that traffic intercellularly bw tumor cells & macrophages Work of amazingly talented co-first authors @WeiQinChemBio and @CheahJoleen, and collaborators Steve Carr @namude & Paul Taylor authors.elsevier.com/a/1hKLc…

Super excited to have actually finished my PhD yesterday!! Also will treasure the memory of a lab member aggressively defending us from this bug with her heel during the talk 🤣🤣

Message of the year: How do you spot an idiot? Look for the person who is cruel. The kindest person in the room is often the smartest. 🏆 @GovPritzker

Poorly characterized polyclonal antibodies are one of the biggest sources of irreproducibility in bio research. Sign on to advocate for renewable (monoclonal and recombinant) antibody resources and standards for characterization. bit.ly/3NpLrDC