Professor of Molecular Therapeutics and Metabolic Biology at UC Berkeley; Departments of Molecular & Cell Biology and Nutritional Sciences & Toxicology
Joined August 2018
- Tweets 10,034
- Following 6,391
- Followers 11,017
- Likes 47,974
435 Photos and videos
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Feb 25
1/ Thrilled to share our new paper in @Nature: “CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.” From our lab together with @apsarruda, led by co–first authors @alymathiowetz and @EmilyMeymand. 🥳
nature.com/articles/s41586-0…
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Jun 11
Excited to highlight our newest work on an induced proximity-based targeted transcriptional repression platform termed Transcriptional Repression via Active Chemical Epigenetic Reprogramming (TRACERs)! Congrats to @CEStieger and co-authors and our @NovartisScience collaborators!! (1/9)
pubs.acs.org/doi/10.1021/acs…
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Very excited to be sharing our new paper, just out in Nature Cell Biology! nature.com/articles/s41556-0…
The big question we investigate: How do migrating cells put their front 🔴 and back 🔵 in the right place?
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Our latest study out in @MolecularCell explores how and why MHC class I is aberrantly targeted for degradation via the autophagy-lysosome pathway in pancreatic cancer. Congrats to postdoc extraordinaire @marineberquez for leading this study! @UCSFAnatomy @UCSFCancer
May 29
Online Now: A multi-subunit autophagic capture complex facilitates degradation of ER-stalled MHC class I in pancreatic cancer dlvr.it/TSn7r3
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Very cool study by @rushika_perera lab uncovers the mechanisms of autophagic degradation of MHC-I to achieve immune masking of PDAC cells
Our latest study out in @MolecularCell explores how and why MHC class I is aberrantly targeted for degradation via the autophagy-lysosome pathway in pancreatic cancer. Congrats to postdoc extraordinaire @marineberquez for leading this study! @UCSFAnatomy @UCSFCancer
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Happy to share our review proposing seipin as a lipid rheostat, not just a #lipiddroplet biogenesis factor. Its flexible structure enables it to integrate metabolic cues at organelle contacts, coordinating lipid storage, membrane synthesis & signaling. hubs.la/Q04jXmy_0
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Jun 3
Exciting new work from @RobertoZoncu, led by all star first authors @clairegoul and @aakritijain24 reveals the mechanism mediating the sensing of lysosomal damage and recruitment of ESCRT for membrane repair. Beautiful work!🤩
nature.com/articles/s41586-0…
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Excited to share our new paper: 'LASER couples damage sensing to ESCRT assembly for lysosome repair.' Congrats to dream team @clairegoul and @aakritijain24 for uncovering a new lysosome repair pathway and its connection to neurodegeneration. bit.ly/49FCPoq
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Jun 2
Interested in lipids and lipid droplets? This is the meeting to attend this summer! See you there! 🤩
Great news! Early registration for the FASEB #LipidSRC has been extended until June 14! It is not too late to submit an abstract and present at the premier North American #LipidDroplet meeting events.faseb.org/event/544fc…
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James Olzmann retweeted
Great news! Early registration for the FASEB #LipidSRC has been extended until June 14! It is not too late to submit an abstract and present at the premier North American #LipidDroplet meeting events.faseb.org/event/544fc…
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May 27
One microscope, every scale. MOSAIC images life from single molecules to whole organisms: dividing cells, remodeling organelles, regenerating zebrafish, Alzheimer's tissue at the nanoscale, live mouse neural dynamics. Credit: Fu, Liu, Milkie, Ruan et al., Nature Methods (2026).
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May 19
Happy to have contributed to this preprint with Fangzhu Zhao and @realJimWells! LRP8-targeted bispecific antibody degraders degrade the selenium uptake receptor LRP8, reduce GPX4 / selenoproteins, and sensitize cancer cells to ferroptosis.
biorxiv.org/content/10.64898…
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May 18
Proud to hood Sydney Tomlinson as she earned her PhD in Metabolic Biology at UC Berkeley. Sydney’s dissertation uncovered mechanisms for induced degradation of ER membrane proteins and advances our understanding of ER quality control.
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May 16
Some friendships just keep getting better with time. Really thankful for these guys, the conversations, the laughter, and the chance to slow down and enjoy an evening together. BFFs!☺️ @RobertoZoncu @RapeLab @DanNomura
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Another collaborative paper with Roop Mallik’s lab @BsbeIitb @iitbombay is now online @pnas @PNASNews. Wonderful lipidomics work by @the_dope_drug from our lab @IISERPune.
pnas.org/doi/10.1073/pnas.25…
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May 12
Thrilled to welcome Michael Ward to the Molecular Therapeutics Division at UC Berkeley! 🎉 An incredible addition to our community and a big win for neuroscience and therapeutics at Berkeley. Woohoo!!
May 12
MCB is pleased to welcome Michael Ward, Professor of Molecular Therapeutics, on July 1st! Read more about Dr. Ward's research and appointment to UC Berkeley @UCBLettersSci:
ls.berkeley.edu/news/michael…
ALT Michael Ward joins MCB faculty
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James Olzmann retweeted
May 12
MCB is pleased to welcome Michael Ward, Professor of Molecular Therapeutics, on July 1st! Read more about Dr. Ward's research and appointment to UC Berkeley @UCBLettersSci:
ls.berkeley.edu/news/michael…
ALT Michael Ward joins MCB faculty
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May 11
Thrilled to share our new preprint from the Doudna Lab!
“Undruggable” cancer mutations remain very hard to target with current modalities. What if we could instead sense mutant transcripts and convert that recognition into selective cell killing?
biorxiv.org/content/10.64898…
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May 11
Great to see this Spotlight article in Trends in Cell Biology highlighting our recent identification of a lipid droplet quality control pathway in which FSP1 protects PUFA-rich neutral lipids from peroxidation, thereby suppressing ferroptosis.
cell.com/trends/cell-biology…
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