cutting edge genetics and tumor biology research lab focused on characterizing and developing therapeutic strategies for brain cancer

Joined June 2019
14 Photos and videos
Big congrats to Abhi Banerjee, Bioengineering PhD student- one of five winners of this year's Graduate & Professional Student Association Interdisciplinary Research Award at UCSD! Novel, impactful, interdisciplinary work recognized at the highest level.@AdamEnglerUCSD @ucsdbe
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Huge congrats to Christopher Chie on being awarded a Servier-Sontag Foundation PhD Student Fellowship for his work on RNA-binding protein dependencies linked to TERT promoter mutations in GBM. Exciting science, very well deserved! @UCSDBMS
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Incredible work by grad students Brett Taylor and Weixiu (Jenny) Dong showing order within the chaos of GBM heterogeneity. Check out biorxiv.org/content/10.64898… for details!

We developed a single-molecule, multi-modal spatial genomics approach to visualize the structure and function of >100,000 individual extrachromosomal DNA (ecDNA) molecules in their native contexts. Preprint link at the end of the thread. (1/11)
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Frank Furnari retweeted
Thank you for all the collaboration and mentorship over the years, Yang!! Will be doing a thread soon 😎
Very exciting and inspiring study coming out from the lab led by @brettmaxtaylor and Weixiu Dong. A method to measure copies, structure, both cellular and intracellular distribution of ecDNA and how these are associated with GBM. Check it out!
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Frank Furnari retweeted
Chromosome-shattering is one reason some #cancer cells evolve rapidly & resist treatment. For 15 years the cause was unknown. Our @FurnariLab, Ludmil Alexandrov & other @UCSanDiego researchers solve the mystery this month in @ScienceMagazine: bit.ly/4paoNA1 #MedTwitter

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Frank Furnari retweeted
You're invited THIS THURSDAY, DEC. 11 to hear Dr. Mariella Filbin speak on Form Follows Function: Cellular and Developmental Architecture of Pediatric Brain Tumors. REGISTER HERE: calendar.ucsd.edu/event/SSCI… @ucsdstemcell @SSCDiscovery @UCSDMedSchool @sbpdiscovery @UCSDHealthSci
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Frank Furnari retweeted
Replying to @FurnariLab
@FurnariLab Clara was awarded first place for her oral presentation at the Prion 2025 conference! We’re so proud!two awards in the past two weeks at major scientific events! Way to go, Clara 👏🎉👏🤩
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Amazing student!
Replying to @FurnariLab
@FurnariLab Clara won first place for her oral presentation , we are all so proud of her! We are grateful to you and your team 🥰
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Frank Furnari retweeted
Replying to @FurnariLab
@FurnariLab Clara won first place for her oral presentation , we are all so proud of her! We are grateful to you and your team 🥰
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Congrats to project scientist Raghav Vadla on his paper showing BRD2 bromodomain-mediated regulation of cell state plasticity. tinyurl.com/Vadla-et-al An exciting new direction to modulate therapy response in GBM! @NeuroOnc @NIHBrainTumor @UCSanDiegoDRM
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Frank Furnari retweeted
**Mark your calendars** Dr. Sean Morrison will be here Thursday, June 12 at 9:30am to speak on the Hematopoietic Stem Cell Niche and Implications for Clinical Transplantation. @ucsdstemcell @SSCDiscovery @UCSDMedSchool @sbpdiscovery @salkinstitute Zoom: ucsd.zoom.us/j/95780022234
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Frank Furnari retweeted
UCSD BMS student, Clark Wang, just gave an excellent talk on his new model of iPSC-derived ATRT at the Pediatric Neuro-Oncology conference in our home town of San Diego. @ucsdstemcell @UCSDBMS
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Frank Furnari retweeted
Replying to @UCSDBMS
@UCSDBMS student, Clark Wang, just gave an excellent talk on his new model of iPSC-derived ATRT at the Pediatric Neuro-Oncology conference in our home town of San Diego. @ucsdstemcell @FurnariLab
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We just had our Furnari lab white elephant holiday celebration! A fun time was had by all.
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Come join us in our quest to cure brain cancer! We are looking for an assistant project scientist to join our UCSD team. Apply here if you are highly motivated and have experience with brain tumor models, drug delivery, stem cells, and molecular biology. apol-recruit.ucsd.edu/JPF041…

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Frank Furnari retweeted
Droplet Hi-C is a new method that uses tiny droplets to analyze the structure of DNA in individual cells. 🧬 MCC's Dr. Rafael Bejar, Dr. Bing Ren, and @FurnariLab discuss how this method allows researchers to study gene regulation in brain cells & detect genetic changes in cancers: bit.ly/3C6bnlK. 🔬 @NatureBiotech
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Frank Furnari retweeted
Incredible technology and work by @LeiChangpku @Xieeee4. Honored to have been able to contribute to its application to cancer—it was such an incredible team to work on, and we got to study my favorite topic: the interplay between ecDNA and cell identity.
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Chromatin interactions profiles are useful, but how can we deconvolute cell-type info from the complex tissues? 🎯 Led by @LeiChangpku , we just released Droplet Hi-C: a faster, cheaper, and high-throughput single-cell Hi-C method using microfluidics: nature.com/articles/s41587-0…
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Frank Furnari retweeted
Our Chair Dr. Alexander Khalessi (@DrAlexKhalessi) talks about advances in neurosurgery techniques and personalized stem cell-based therapeutics for brain tumors during the launch of the Brain Tumor and Neurorestoration program, in partnership with @ucsdstemcell!
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