Unlocking the mysteries of stem cells. To learn more follow @SignerLab.
Joined May 2009
- Tweets 45
- Following 91
- Followers 143
- Likes 131
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Robert Signer retweeted
4 Nov 2021
Why is it so difficult to grow hematopoietic stem cells in culture? Huge increases in protein synthesis disrupt proteostasis in HSCs ex vivo. HSF1 comes to the rescue ex vivo & during aging to keep stem cells fit. Our latest now in print @CellStemCell cell.com/cell-stem-cell/full… 🧵
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Robert Signer retweeted
13 Sep 2021
FREE registration for the Sanford Stem Cell Symposium is now open. Join our incredible lineup of speakers discussing stem cells in regenerative medicine, cancer, aging, bioengineering, genomics 🧬 & space 🚀.
Agenda: stemcells.ucsd.edu/sanford-s…
Registration: eventbrite.com/e/sanford-ste…
Please join us on October 14-15th for the Inaugural Sanford Stem Cell Symposium!
Registration Link: eventbrite.com/e/sanford-ste…
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Robert Signer retweeted
19 Aug 2021
.@UCSDMedSchool researchers unlock a way to keep lab-grown stem cells healthy, which is positive news for people who need bone marrow transplants when donor stem cells are not available. The approach may also help further aging research.
ow.ly/nSpg50FR4Vi
ALT Illustration showing the HSF1-mediated heat shock pathway that promotes proteostasis in hematopoietic stem cells in culture and during aging. Photo credit: Cell Press
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Robert Signer retweeted
12 Aug 2021
If you can’t take the heat, get out of the culture. Our latest paper in @CellStemCell uncovers how HSF1 keeps stem cells fit in a dish. 🔥💪 authors.elsevier.com/sd/arti…
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Robert Signer retweeted
13 Feb 2021
While we’re focused on the BIG discoveries that enabled the rapid development of the #COVID vaccine, let’s not forget the engine that powered it: trainees, long days, failed experiments, rejection, persistence, resiliency. This is progress. This is science.
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Robert Signer retweeted
12 Jan 2021
Why do some genetic disorders present in kids and others in adults? Our new paper w/@Magee_Lab reveals that BIG changes in protein synthesis during ontogeny sensitize distinct hematopoietic cell types to a ribosomal mutation in an age-dependent manner. cell.com/stem-cell-reports/f…
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Robert Signer retweeted
5 Nov 2020
Attention hematopoiesis community: Have you ever been confused about which set of markers to use to identify HSCs and MPPs? We hope to bring clarity & unity to the field. Tune in to this important @ISEHSociety webinar on Tuesday, November 10th!
5 Nov 2020
MPPs – As easy as 1-2-3? Or is it HPC and ST-HSC? Confused on how to identify multipotent progenitors (MPP) by flow? ISEH can help! Join @challenlab, @Nina_CabezasW, @pietras_eric, @SignerLab, @BeermanHSCaging on 10 November for our Fall Webinar! iseh.org/isehwebinars
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Robert Signer retweeted
21 Sep 2020
ERADicating stem cells from their niche. Our News & Views on exquisite new work from @XiChenLab in @NatureCellBio on how proteostasis regulation by the ERAD pathway influences the interaction of HSCs with their perivascular niche in the bone marrow. rdcu.be/b7vFR
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Robert Signer retweeted
24 Aug 2020
Why do ribosomal mutations only impair certain cell types? Developmental stage-specific changes in protein synthesis differentially sensitize hematopoietic stem cells and erythroid progenitors to impaired ribosome biogenesis. New preprint w/@Magee_Lab. disq.us/t/3r7tu57
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Robert Signer retweeted
1 Jul 2020
Humbled to be included with these outstanding scientists. Thank you @LLSusa, @TheMarkFdn & @AllenInstitute for supporting our innovative research targeting protein synthesis to treat blood #cancers.
1 Jul 2020
As we seek to ignite the next major breakthroughs to treat blood #cancers alongside @TheMarkFdn and @AllenInstitute, we are excited to announce that we have awarded $6.75 million to nine of the most exceptional scientists in the field. Learn more >> bit.ly/2CZzqnX
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Robert Signer retweeted
11 Jun 2020
The proteostasis network functions uniquely in hematopoietic stem cells to promote their life-long regenerative function. Learn more in our latest review in @CO_Hematology. journals.lww.com/co-hematolo…
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Robert Signer retweeted
17 Mar 2020
My op-ed in @sdut explains why we all must stay home and practice responsible social distancing to safeguard our communities. #coronavirus #COVID19v@UCSDHealth @Kevin_Faulconer @CityofSanDiego @CAgovernor
17 Mar 2020
Commentary: Amid coronavirus outbreak, San Diego medical professor explains why staying home is essential dlvr.it/RS1NfK [Opinion]
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Robert Signer retweeted
17 Mar 2020
My op-ed in @sdut explains why we all must stay home and practice responsible social distancing to safeguard our communities. sandiegouniontribune.com/opi… #coronavirus #COVID19 #UCSDHealth @Kevin_Faulconer @CityofSanDiego @CAgovernor
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Robert Signer retweeted
14 Feb 2020
The @SignerLab is hiring Postdocs! Our curious and creative team @UCSDHealth investigates how the proteostasis network is uniquely configured to promote stem cell function and longevity, and encompasses new therapeutic targets in cancer. Info: signerlab.com. Please RT!
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Robert Signer retweeted
6 Feb 2020
DNA isn’t destiny. Stem cell identity and function depend on the epitranscriptome, translational control and protein degradation to regulate proteome content, quality & complexity. New review on post-transcriptional control of stem cells in @CellStemCell. sciencedirect.com/science/ar…
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Robert Signer retweeted
13 Jan 2020
Modest declines in proteome quality impair hematopoietic stem cell self-renewal bit.ly/2NopWoq
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Robert Signer retweeted
13 Jan 2020
Misfolded proteins are associated with Alzheimer’s, Parkinson’s and other neurodegenerative diseases. New research reveals that misfolded proteins also impair stem cell function and tissue regeneration. cell.com/cell-reports/fullte… #stemcell #proteostasis #sparkjoy
13 Jan 2020
Modest declines in proteome quality impair hematopoietic stem cell self-renewal bit.ly/2NopWoq
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Robert Signer retweeted
8 Jan 2020
The Science of Tidying Up: Stem cells depend on low protein synthesis to prevent the biogenesis of misfolded proteins. cell.com/cell-reports/fullte…
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