Our new preprint is a significant milestone for us
We built "HealthFormer" by training on our deeply phenotyped cohort from the Human Phenotype Project data. Healthformer is a multimodal generative transformer model that tokenizes each participant's physiological trajectory across 667 modalities (biomarkers, body comp, sleep, CGM, microbiome, wearables, meds) and is trained with a single objective: predict the next measurement
Forecasting, risk stratification, and intervention-conditioned simulation all arise as queries from one shared representation
Key findings:
→ Matches direction of effect in 41/41 published RCTs; 30/41 within the reported 95% CI
→ Reconstructs biomarkers at r > 0.9; forecasts 2 yrs ahead
→ Validation on external data from UK Biobank, NHANES, PNP3, Framingham
→ Outperforms Framingham CVD & PREVENT-ASCVD on 27/30 endpoints
→ Predicts individual 6-mo responses in a held-out RCT
Paper:
arxiv.org/abs/2604.27899
Great work by Guy Lutsker, Gal Sapir, Jordi Merino, Smadar Shilo, Anastasia Godneva, Eli Meirom, Shie Mannor, Hagai Rossman, Gal Chechik