Novo Nordisk leaders claiming that Tirzepatide has never seen a 25% weight loss, not in a trial and not in real world, is such a shame. I am really really disappointed. I mean, it is crazy.

I love this callout because this something NONE of the Lilly folks are toplining 🤨 ⭐️Let's clarify: 1. Orforglipron DOES work with statins 2. Orforglipron might actually help some statins work BETTER 3. Most patients I know are on atorvastatin or rosuvastatin 👉 orforglipron may ⬆️ these statin's plasma concentrations (1.5-1.7x depending on dose) So far, the only official guidance we have from the manufacturer is to cap simvastatin dose at 20 mg/d... 🧐But I wonder if real-world experience will allow people to take atorva/rosuvastatin every other day or at lower doses when they're on orforglipron too

I’ve decided this is my official reaction to this call. “What. Was. That?!” IYKYK

My understanding is that someone from $NVO made a comment today about issues with “statins” and orforglipron (that you have to delay using statins for 2-4 hours after taking orfo based on Lilly trial protocols). $LLY CEO was asked about it and said they haven’t done any drug interaction studies but that the protocol from the studies was based on the other drugs having their own warnings about their use - not orforglipron having a specific issue. He said they don’t anticipate having any warnings on the orforglipron specific to other meds. I checked. There is only ONE statin listed in the ATTAIN-1 protocol with a warning to delay its use. That statin, simvastatin, does in fact have a warning to take it at night on an empty stomach in one of its forms. No other statins were on the list. I checked two other common statins that weren’t on the list: Lipitor (atorvastatin)and Crestor (rosuvastatin). Why not? Their labels say you can take them whenever you want, with or without food. They don’t require empty stomachs or special timing. So no - there was not a blanket delay for statins. The delay recommendation was for A statin that has specific requirements for its administration. I assume the other meds on the list have similar issues.

$LLY vs $NVO: Eli Lilly says it has the edge in the obesity pill race Eli Lilly’s international chief says oral weight-loss drugs could become the largest segment over time, as most patients prefer pills over injections. Lilly expects U.S. approval of its pill (orforglipron) in H1 2026, followed by Europe late 2026 and a global rollout in 2027, and says it already has capacity to supply global demand. Lilly argues it has three advantages vs Novo Nordisk’s Wegovy pill: • No fasting or timing restrictions • A small-molecule drug that’s easier and cheaper to produce at scale • More flexible dosing for long-term maintenance therapy Lilly expects limited cannibalization of injectables, saying pills mainly serve needle-averse patients and maintenance use. Big banks like Citi and Jefferies estimate Lilly’s pill could reach $30–40bn in peak sales, well above current expectations for Novo’s pill. Link to article (in Danish): borsen.dk/nyheder/virksomhed…

Happy New Year 🎆 May 2026 finally be the year of @Charles_Leclerc in F1 🥺❤️

RT @sixteencar: my predictions for the 2026 season 🇧🇭 LEC 🇸🇦 LEC 🇦🇺 LEC 🇯🇵 LEC 🇨🇳 LEC 🇺🇸 LEC 🇮🇹 LEC 🇲🇨 LEC 🇨🇦 LEC 🇪🇸 LEC 🇦🇹 LEC 🇬🇧 LEC 🇭🇺…

the first video you need to start 2026 right.

VTX3232 monotherapy achieved ~80% reduction in hsCRP within the first week Here are some CV drugs and their impact on hsCRP

this was truly the longest and most depressing radio ever 😭🙃🙃

Hi @AlexBrundle, thank you so much for taking the time to go through my analysis! I’m more aligned with what Ferrari said, and my hypothesis specifically calls out the higher roll center in the new suspension which means that the suspension arms and all interconnect points need to bear more load now than in the previous suspension. As I mention in my post, I don’t know how often they change up the car’s parts but given last week was Spa where the suspension arms/chassis faced significant vertical load, they may already be weakened with the HUN GP being the final straw. If my hypothesis is correct, the issue likely should be mounting points/interconnections between suspension and chassis. Those I believe can be made of titanium (alloys) and can deform under high load. Which is why the situation got progressively worse since LEC first called it around lap 26 (and not stint 3 as you theorise). Your definition of ‘ideal deployment’ seems to be the one that optimises EOSS. But LEC was already on your definition of ideal deployment on lap 26 when he first complained of inconsistencies with the car and thought the team did something without telling him. The instruction for removing hybrid power for EOSS (mode FS1) was given sometime around lap 27 or 28. What LEC felt was likely the beginnings of this chassis/suspension interconnect issue which just progressively got worse from there on out. In the first stint, once FS1 was initiated, the time improvement in the corners was very visible. In the second stint, even after FS1 was initiated, the cornering was barely faster than the EOSS mode. By stint 3, potentially because the suspension (already in a delicate condition) was lifted and then dropped by the rear jack during the pit-stop, the whole thing got even worse and the lap-times just collapsed. As you say, from the outside we can’t say what really happened. However, I personally find the tyre pressure argument logically inconsistent. Why would Ferrari go for EOSS in the last ~15 laps of the race if you’re trying to minimise plank wear by ‘raising’ the car via higher tyre pressures. They could’ve saved themselves the massive performance losses and done LICO instead to manage plank wear… Thanks again for reading my analysis and sharing your views!! Traces via @f1insightshub

Hello darkness, my old friend… #F1 #Ferrari #Leclerc #HungarianGP This weekend has been a roller-coaster of emotions. It took me a while to put aside my disappointment and try and make sense of what happened… We were fast in the first ~40 laps - similar pace as the McLs. But Charles’ pace in the last stint was terrible. And honestly, this doesn’t look like the low fuel pace issues that we had before the rear suspension update (& we didn’t see low fuel pace issues at Spa). Lots of theories have been floating around. I don’t think front wing flap change or using higher tyre pressure on H tyres can cause such a drop-off. Also note that those theories were based on Charles’ radio in the 2nd stint where he wasn’t happy with what he thought were Ferrari’s decisions. But the thing is, he was still competitive in the 2nd stint. Whatever he was starting to sense/experience, just got worse and in the last stint made the car completely uncompetitive. In last 30 laps, he lost ~40 seconds of race time vs. Piastri! Another theory that is floating around is that they used engine modes that reduced power at end of the straights to preserve the plank and that was causing time loss. I looked through the laps and it just feels like a hybrid power mapping. Charles was asked to move to Mode FS1. It looks like that mode changes hybrid power deployment mapping to corners instead of straights. I have compared laps 4 and 17 from 1st stint and the laps 22 and 34 from 2nd stint. In both traces (via @f1insightshub), there isn’t much change in the actual lap time. The only difference is how that lap time is obtained. Within FS1 mode, Charles is faster in the corners while in the other mode, Charles is faster in straights as hybrid power is used for end of straight speed (EOSS). So using MODE FS1 did not cause a time loss of 40 secs. But when you look at the 3rd stint (where I’ve compared 9-10 laps), some patterns are noticeable. In the beginning of 3rd stint, CL is on MODE FS1, so he is faster in the corners. However, speed/time gained in corners keeps reducing through the 3rd stint. In the latter part of the 3rd stint, Charles is moved to the mode that provides EOSS, but even then the time now gained on straights is not enough to offset time lost in corners. So the issue in 3rd stint appears to be related to rapidly declining cornering performance and NOT as some claimed due to loss of straight-line speed because of the mode Ferrari was using. If anything, the better EOSS (due to declining fuel load) in the latter part of the 3rd stint was the only thing that was somewhat offsetting cornering issues. So what is the issue then? The team has said it is an issue with the chassis and I think that aligns more with the data. Although, I have a more specific theory. When I posted on the suspension update (quoted below), I was worried if the suspension arms could withstand the higher load now passing through them. When you raise roll center (RC), a greater proportion of the vertical load in corners goes through suspension linkages compared to springs/dampers. If the connections between the new suspension arms & the chassis is not strong enough to withstand this additional load, then it can cause stress to chassis (& destroy cornering performance) I don’t know how often they change up the car’s parts but given last week was Spa where the suspension arms/chassis faced significant vertical load, they may already be weakened with the HUN GP being the final straw. @ScuderiaFerrari need to regroup this summer and understand how the chassis got weakened and whether new stronger parts or new processes (like changing parts after every race) are needed.

#F1 #HungarianGP FERRARI, LECLERC : modes moteurs, pressions pneus & usure du sous-bassement : les FAITS (1/19) 1) Tour 9 : BOZZI demande à LEC de changer un réglage. "Mode FS1, mode FS1" 1 minute tard, LEC se plaint (entendu à la TV) : "il se passe quoi avec les coupures ?!"

Chose your fighter: Hungary25 or Vegas24

🚨| Ferrari were close to the limit with floor/plank wear due to changing the engine mapping, and had to use higher tyre pressures to raise the car in that third stint, claims George Russell. My question is, could tyre pressures alone contribute 1 second per lap?

Stowe'da başka da hatası varsa bilmiyorum. Bu sene sıkılıp f1tvden onboard izlemeyi bıraktım, rejiler de biliyorsunuz bazen farklı yarışları izletebiliyorlar

yep this will be my new favourite reaction picture thank you 1681

Charles in this second medium stint: Lico, Lico, Lico. No wonder the pace is nowhere ☹️