Popgen @UCDavis. @gcbias@ecoevo.social . Tweets, grammar, & spelling are my views only.He/him. #OA popgen book github.com/cooplab/popgen-no…

Joined July 2012
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Your ancestors lived all over the world, but relatively few of them were your genetic ancestors (does that matter?) gcbias.org/2017/12/19/1628/
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Graham Coop retweeted
A few thoughts on Herasight, the new embryo selection company. First, the post below and the white paper imply that competitors like Nucleus have been marketing and selling grossly erroneous risk estimates. This is shocking if true! 🧵
At @herasight, we wanted to compare our genetic predictors (PGS) to those from @nucleusgenomics. However, in many cases, we couldn’t reconcile plausible performance of their PGSs with customer risk reports we saw — this may have misled customers about their disease risks.
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It is depressing, but all too predictable, how swiftly we’ve gone from the Social Science Genetic Association Consortium offering reassurances about the uses of behavioural polygenic scores to one of their lead authors marketing embryo selection for IQ
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Herasight, named after the goddess who threw her disabled child off a mountain, seems focused on public outreach using embryo selection for IQ to win over far rightwing pseuds & techbros
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These embryo-selection startups are clearly feeding into an alt-right ecosystem that revels in techno-futurism much as such movements have in the past. GWAS participants & parents navigating IVF deserve better than being used as tools to attract the attention of edge lords.
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Graham Coop retweeted
#PrivateEquity owned Global Medical Response is also one of the biggest funders of #Prop35. The same PE firm that bankrupted Toys R Us is coming for our Medi-Cal program. #NoOn35 @healthaccess @JimWoodAD2 @CPEHN @CourageCA
#PrivateEquity is everywhere. Let's start here: Shell, Exxon, Chevron, Unocal don't own gas stations. They are "Sometimes [owned] by private equity firms and they can raise prices very liberally because -- simply because -- they can" abc7.com/california-gas-pric… 🧵
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Graham Coop retweeted
I wrote a bit about the two very interesting studies of siblings/families from last week. Tan et al. family GWAS (medrxiv.org/content/10.1101/…) and Sidorenko et al. sibling heritability estimates (nature.com/articles/s41588-0…). A few surprising findings summarized here: 🧵
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Looking for examples for class of STRUCTURE-style bar plot of hunter gather, early farmer, and steppe ancestry proportions for Europeans. Arranged temporally to shows various turn overs. Looking for something broad in temporal scope but simple enough to talk undergrads through.
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Graham Coop retweeted
Chapter 3.4 describes how ancient DNA has reshaped our understanding of the human past.
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Graham Coop retweeted
Two new chapters from my free online book in human genetics out this weekend! These complete Part 3 of the book, on human population structure and history: 3.3: Inferring human prehistory from genetic data [this thread] 3.4: Ancient DNA [next thread] web.stanford.edu/group/pritc…

I'm delighted to release the first half of my new open-access online textbook in human population genetics: web.stanford.edu/group/pritc…
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Graham Coop retweeted
Excited to share this new preprint with @spence_jeffrey_ and @DocEdge85 in which we developed a method to infer demographic history and mutation rates from millions of genomes, and applied it to gnomAD v4 data. Read on for a brief thread! biorxiv.org/content/10.1101/…
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Graham Coop retweeted
Estimation of demography and mutation rates from one million haploid genomes biorxiv.org/cgi/content/shor… #biorxiv_genomic

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Graham Coop retweeted
Really interesting new paper from Akbari et al. identifying a lot more selection in ancient DNA than previous approaches. I think it gets at three core challenges for this type of analysis where our understanding is still limited. 🧵
Congratulations to Ali Akbari @aliakbari23 on his amazing new work on selection in Western Eurasia that is finally released as a preprint after years of painstaking work. Accompanying it is a selection browser (beta) reich-ages.rc.hms.harvard.ed… biorxiv.org/content/10.1101/…
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Finally, the authors rely heavily on LDscore regression throughout the paper to rule our concerns about confounding (including in their PGS analysis). But LDscore results were shown to be very misleading in previous analyses of polygenic selection elifesciences.org/articles/3… 25/
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TLDR The polygenic selection signals could be interesting, but the paper falls short of making a convincing case.
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