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henrike heyne @HHeyne

lecturer at HPI, adjunct faculty HPI MS NY. previously @FIMM_UH @broadinstitute @MGH_RI. clinical genomics, precision medicine, epilepsy. @hheyne.bsky.social

Joined April 2014
  • Tweets 721
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  • Followers 669
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henrike heyne@HHeyne
30 Jul 2024
Replying to @HHeyne
We found that a high genetic generalized epilepsy PRS (PRS-GGE) increased risk for genetic generalized epilepsy (GGE) (hazard ratio [HR] 1.73 per PRS-GGE standard deviation) across lifetime and within 10 years after an unspecified seizure event. 3/6
Fig. 3: In each panel, on the left are density curves that display how samples are partitioned into six bins of PRS standard deviations. Survival curves in the middle give the cumulative epilepsy incidence (y-axis) across time (x-axis [years]) stratified for epilepsy PRS bins. The rightmost forest plots show epilepsy risk of each epilepsy PRS bin compared with the rest of the cohort. (A) GGE (n = 924) across lifetime, (B) GGE (n = 266) after an unspecified seizure, (C) NAFE (n = 5509) across lifetime, (D) NAFE (n = 1290) after an unspecified seizure. In (A, B), we investigate PRS-GGE, in (C, D), PRS-NAFE.

ALT Fig. 3: In each panel, on the left are density curves that display how samples are partitioned into six bins of PRS standard deviations. Survival curves in the middle give the cumulative epilepsy incidence (y-axis) across time (x-axis [years]) stratified for epilepsy PRS bins. The rightmost forest plots show epilepsy risk of each epilepsy PRS bin compared with the rest of the cohort. (A) GGE (n = 924) across lifetime, (B) GGE (n = 266) after an unspecified seizure, (C) NAFE (n = 5509) across lifetime, (D) NAFE (n = 1290) after an unspecified seizure. In (A, B), we investigate PRS-GGE, in (C, D), PRS-NAFE.

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henrike heyne@HHeyne
10 Sep 2024
Great to see @FrancescaRissom present on her work on ion channel variant prediction @gmdsEV, only one year into her PhD #proudPI
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Great talk by @SusanneIbing on using automated phenotype classification comparing low effort GPT-4 vs rule based approach in Crohns @gmdsEV #gmds2024 >> good to safe work? check out her preprint medrxiv.org/content/10.1101/…
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Great opening talks by @MI_Sedlmayr and Andreas Seidler of the common conference of 5 German scientific societies incl. #gmds #TMF2024 "Gesundheit gemeinsam"/"health together".
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Doc Edge@DocEdge85
25 Aug 2024
This is wrong, but there is a lot of confusion about why (thread)
Jean-François Gariépy 🧬
@JFGariepy
24 Aug 2024
Most people don't realize that interbreeding with other races means that strangers on the street from your own race are more related to you than your own child. Amplify this, @elonmusk and spread the knowledge!
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Sumaiya Iqbal@Sumaiyalqbal
19 Aug 2024
📣 We are seeking a part-time, 20 hrs/week, UI/UX developer/SWE consultant (or paid affiliate) in the Genomics 2 Proteins portal (g2p.broadinstitute.org/) project. The required skills are React.js and Google Cloud services. Contact me @ <sumaiya@broadinstitute> if interested!

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henrike heyne@HHeyne
12 Aug 2024
I very much enjoyed writing this @NatureNV piece on the RNU4-2 story. Please read on if you want to learn more about how a non-coding variant was discovered to be one of the most frequent causes for developmental diseases. (thx M. Rissom for sketch) nature.com/articles/d41586-0…
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henrike heyne@HHeyne
30 Jul 2024
Analogously, we found significant but more modest focal epilepsy PRS burden associated with non-acquired focal epilepsy (NAFE). 5/6
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henrike heyne@HHeyne
30 Jul 2024
Again, a pleasure to work with data from @FinnGen_FI, also glad to collaborate with @ESTbiobank and BioMe (@HPI_MS). Thanks to great collaborators @JulianWanner @FannyDhelia @JDanOchekwa @m_reedik @APalotie @dalygene @rkalviainen 6/6
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henrike heyne@HHeyne
30 Jul 2024
The effect of PRS-GGE was significantly larger on idiopathic generalized epilepsies, in females and for earlier epilepsy onset. 4/6
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henrike heyne@HHeyne
30 Jul 2024
Epilepsy diagnosis is often challenging. The most widely-used diagnostic tool -EEG- performs quite variably. Here, we investigated how common genetic factors (polygenic risk scores, [PRSs]) influence epilepsy risk in electronic health records of > 700k Finns and Estonians. 2/6
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henrike heyne@HHeyne
30 Jul 2024
We found that a high genetic generalized epilepsy PRS (PRS-GGE) increased risk for genetic generalized epilepsy (GGE) (hazard ratio [HR] 1.73 per PRS-GGE standard deviation) across lifetime and within 10 years after an unspecified seizure event. 3/6
Fig. 3: In each panel, on the left are density curves that display how samples are partitioned into six bins of PRS standard deviations. Survival curves in the middle give the cumulative epilepsy incidence (y-axis) across time (x-axis [years]) stratified for epilepsy PRS bins. The rightmost forest plots show epilepsy risk of each epilepsy PRS bin compared with the rest of the cohort. (A) GGE (n = 924) across lifetime, (B) GGE (n = 266) after an unspecified seizure, (C) NAFE (n = 5509) across lifetime, (D) NAFE (n = 1290) after an unspecified seizure. In (A, B), we investigate PRS-GGE, in (C, D), PRS-NAFE.

ALT Fig. 3: In each panel, on the left are density curves that display how samples are partitioned into six bins of PRS standard deviations. Survival curves in the middle give the cumulative epilepsy incidence (y-axis) across time (x-axis [years]) stratified for epilepsy PRS bins. The rightmost forest plots show epilepsy risk of each epilepsy PRS bin compared with the rest of the cohort. (A) GGE (n = 924) across lifetime, (B) GGE (n = 266) after an unspecified seizure, (C) NAFE (n = 5509) across lifetime, (D) NAFE (n = 1290) after an unspecified seizure. In (A, B), we investigate PRS-GGE, in (C, D), PRS-NAFE.

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henrike heyne@HHeyne
30 Jul 2024
Hi all, very glad to announce our paper on “Polygenic risk scores as a marker for epilepsy risk across lifetime and after unspecified seizure events” is now out nature.com/articles/s41467-0… in @NatureComms. summary in German here: x.com/HPI_DE/status/18182263… twitter summary below. 1/6

Polygenic risk scores as a marker for epilepsy risk across lifetime and after unspecified seizure...

Nature Communications - In this study, the authors showed how common genetic factors in the form of epilepsy polygenic risk scores influence epilepsy risk across lifetime and after unspecified...

nature.com
Hasso-Plattner-Institut@HPI_DE
30 Jul 2024
Polygene Risikoscores können helfen, die Veranlagung für eine Erkrankung besser einzuschätzen. Dr. @HHeyne vom HPI untersuchte die Gendaten von 5.000 Individuen, um mehr Erkenntnisse über epilepsie-spezifische Polygene Risikoscores zu erlangen. 👉Mehr: hpi.de/news/jahrgaenge/2024/…
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Anshul Kundaje@anshulkundaje
6 Jul 2024
I'm making an open offer to any compbio grad students/postdocs who are aiming for faculty positions. If you have strong impactful research but no glam pubs & need someone to advocate for you, please get in touch. I promise u, I & a bunch of other faculty will strongly support u.
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Dr. Heather Mefford @hcmefford.bsky.social@hcmefford
12 Jul 2022
JOIN US @StJudeResearch! *FACULTY* positions available in Ctr for Peds Neuro Dz Res. All levels, broad interests considered: #neuroscience #Genetics #RareDisease #PrecisionMedicine #stemcells w/@AndrewKodani #academicjobs More info in 🧵 Pls RT! faculty-stjude.icims.com/job…

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Christy W. LaFlamme@cwlaflamme
1 Jun 2024
If you’re in Berlin (or tuning in online) for the #ESHG24 meeting, come out to the late breaking session this Monday (6/3) to hear about #DNAmethylation in the #DEEs 🧠 I’ll describe how we used DNA methylation analysis to solve genetically unresolved cases 🧬
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Daniel MacArthur@dgmacarthur
2 Jun 2024
Reminder for #eshg2024 attendees: my team is looking for senior computational biologists, based in Australia or New Zealand, to work on a variety of cool projects. More details here: populationgenomics.org.au/ca… DM me if you’d like to chat in Berlin!
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Amelie Fritz on sex differences in many human diseases -> disentangling phenotypic and environmental components -> compare phenotypic and genetic correlations, —> mostly shared genetic architecture betw. sexes but more differences in environmental effc. #eshg2924
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interesting talk by Sara Ometto -> extracting latent phenotypes from cardiac MRIs incl. time component. integrating with GWAS overlaps with loci affecting also atrial fibrillation, T2D etc #eshg2024
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Come to A8 -> Large Scale Genetic Association Studies - very nice session chaired by @KristinTsuo and Carlo Maj
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#eshg2924 great work right now in room A8 by @flassen_, PhD student with @ceclindgren @astheeggeggs on compound heterozygous effects in the UK Biobank
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replicate known findings e.g. MUTH and colon cancer. new association like ATP2C2 -> high risk for compound het COPD
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join our cross biobank efforts of recessive effects with @BRaVa_genetics! (@hilsomartin @astheeggeggs and many others)
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