Please follow me on @hake-chromatin.bsky.social!

Dear #Epigenetics Friends & Colleagues – Do YOU know where your histones are? Our Xmas prezzie to the community (and perfect holiday reading): we went hunting for #histones and found them in all sorts of weird and wonderful places. We report here 👇 journals.biologists.com/jcs/…

My lab has been working for the past 15 years to develop a method to isolate specific genomic loci to identify its chromatin composition & protein interactome. Finally,… our superb physician/scientist Dr. Bercin Cenik @bkcenik did it and here it is cell.com/molecular-cell/full… Not only was she able to develop this method, which she calls TurboCAS, she was able to identify known & novel regulators of heat shock & Myc expression. Cannot wait to see what Bercin and TurboCAS will discover about the molecular basis of transcriptional regulation with great impact on clinic in the next few years! @NU_BMG_SQE @NUFeinbergMed @MolecularCell

We had an amazing X-Mas party with members of the Institute for Genetics! 🎄✨ Games, drinks, singing, and a lovely dinner. Many thanks to this incredible team of brilliant and caring scientists. Truly an honor to be part of this unique research family! ❤️

Deeply honoured to receive this year's Gateff Prize by the German Genetics Society @GfGenetik 🎓🧬 Recognition for an incredible team I had the privilege to work with during my PhD. @tcgcambridge @CamVetSchool @sangerinstitute @emblebi @ResearchMenzies

Heute konnte ich an der Universität Gießen über die Entwicklung der globalen Forschung nach der US-Wahl sprechen. Danke für die Einladung!

Our new study, initiated by an undergraduate in the lab, was set to examine the effect of mutating histone H3.3 K122 to alanine. To do so, we attempted to generate murine ES cells mutating all four alleles, but were surprised when we couldn't generate these lines!

Excited to share our study on ZNF512B's role in binding NuRD, acting as a repressor, and facilitating DNA aggregation is now published in @NAR_Open! Big thanks to our amazing collaborators @OlallaLab, @JoelPMackay, Marek Bartkuhn, & Falk Butter! pubmed.ncbi.nlm.nih.gov/3946…

📖 New review in Nature Reviews Cancer on how epigenomic heterogeneity drives tumour evolution! We dive into: Check it out if you're into epigenetics, single-cell tech, or the future of cancer therapy! 📖 nature.com/articles/s41568-0…

Exciting news! Our study on ZNF512B was accepted in @NAR_Open ! Huge congrats to the amazing PhD student and first author Tim Wunderlich and the entire team. Big thanks to all our collaborators! Stay tuned for more details after publication.

7 years ago, I met a junior fellow named @JD_Buenrostro who blew me away with a vision of futuristic genomic technologies Today, we (@ajaylabade31, @carolinecomenho) are excited to share our first steps into that future: Expansion in situ genome sequencing 1/

Thanks to everyone joining our symposium “Quiescence from a Chromatin and RNA perspective” at @jlugiessen — especially our guest and local speakers! Many fruitful discussions and exciting keynote by @keisuke_goda! Looking forward to establishing a new training network @FB08_JLU

Two papers based on my PhD work came out the same day!! 1- Large-scale study mapping the RNA-binding sites of C2H2-zinc finger proteins and other RBPs! authors.elsevier.com/a/1joCM… 2- Role of ZBTB48 in m6A regulation! doi.org/10.1186/s13059-024-0…

The Hake team visited Wetzlar: A retreat of reflection but also team spirit strengthening. A WWII tunnel tour reminded us: NEVER AGAIN! After exploring these dark historical sites, we wrapped up the day at the bowling center. United, we're ready for new challenges!

I am very pleased to share our recent study on prokaryotic histone structure and diversity nature.com/articles/s41467-0… Great work by PhD student @SammyBoterhammy. With @aimeelboyle, @Vikram_Alva, Birte Hernandez Alvarez, Yimin Hu, @MPI_Bio, @LeidenScience

We first saw evidence for this ~ 2019. We were super surprised & skeptical. After 5 years of quintuple cross-validation, we feel confident to share with the world.

POSTDOC OPPORTUNITY TO JOIN US! Are you interested in how nuclear metabolism impacts on chromatin function and gene regulation in leukemia? Apply for an attractive postdoc position with us through the MSCA @carrerasleaders program! More info here: buschbecklab.org/join-us/

Chromatin scientists, want to reorganize genomic loci as you wish? Out today in Cell--We made a tool that uses surface tension of engineered condensates to reposition DNA loci across microns of space in living cells in just a few minutes: VECTOR cell.com/cell/abstract/S0092…

📢ACCESS DENIED!! Ever wonder how heterochromatin causes transcriptional gene silencing and is epigenetically inherited? Excited to share our new story showing that histone deacetylation, a conserved feature of heterochromatin domains from yeast to mammals, limits access to SWI/SNF chromatin remodelers to prevent unraveling of nucleosomes, which enforces gene silencing and maintains high H3K9me3 density required for epigenetic inheritance #epigenetics #heterochromatin #histones #chromatin Congratulations to @rakesh_k_sahu and other lab members! cell.com/molecular-cell/full…

The Genome Biology Dept @EMBL is recruiting - independent group leader (PI) position. We are interested in people addressing important Qs in the broad area of Genomics in creative ways - including AI, #ArtificialInteligence #jobs embl.org/jobs/position/HD026… embl.org/jobs/position/HD026…