Joined September 2021
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Two great days of science at the #SMLMS2022, culminating with a conference dinner on the boat on the Seine. So many great conversations π. Happy to present our choreography to show our appreciation to this event (watch the light pattern!).
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HeilemannLab (ππ» heilemannlab.bsky.social) retweeted
11 Dec 2024
β¦ and perfect timing. Work by @HuaipengXing with @FrydmanLab out @Nature. PDCD5 binds virtually all open #TRiC, while closed TRiC forms clusters inside of cells. Congrats to all authors. rdcu.be/d3dmN
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HeilemannLab (ππ» heilemannlab.bsky.social) retweeted
5 Dec 2024
Open postdoctoral position in my group! jobs-sf.ukmuenster.de/job/UK⦠We search for a very talented student in the field of super resolution microscopy! @UK_Muenster @uni_muenster #academia #newPI
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We modified our STEDπ¬to make it more efficient ('smart') to acquire high-resolution data of small and rare objects in a 3D cell volume. This enabled collecting a large amount of data in a fully automated fashion. With that, we visualized the ultra-structure a nuclear bodyππ»(1/3)
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By labeling the architectural RNA NEAT1 in paraspeckles (PS) at various positions using RNA-FISH-DNA-LNA probes, we learnt 3 new things: (1) the morphological space & shape progression of PS, (2) the orientation/packing of its RNA, (3) the coarse conformation of NEAT1. (2/3)
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Kudos to Enya & Laurell for their fantastic work! Great collabπw/ Bernd Rieger & Sjoerd Stallinga (TU Delft) Michaela MΓΌllerMcNicoll (@goetheuni) & great support by @ashwin0512. We are very excited about the results & curious to see your feedback ππ» doi.org/10.1101/2024.11.28.6β¦
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bsky.app/profile/heilemannlaβ¦
πhoping to re-connect to many of you
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Long-term single-protein tracking up to 30 min allowed monitoring the dynamics of EGFR activation in living cells (and more)ππ»Great work by a fantastic team and great collaboration with @JulianKompa Kai Johnsson @mpi_mr_hd π @sfb1507 @goetheuni
26 Nov 2024
Long-Term Single-Molecule Tracking in Living Cells using Weak-Affinity Protein Labeling (Mike Heilemann and co-workers) @HeilemannLab #openaccess onlinelibrary.wiley.com/doi/β¦
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πhappy that this article is out now: we used an integrative approach (MD, single-molecule imaging, FRET) to reveal early activation of the receptor tyrosine kinase MET in cellsππ»A wonderful collaboration with @CovinoLab & great co-workers π@goetheuni @fias_science @sfb1507
4 Nov 2024
Check out how we used simulations and single molecule FRET to determine how a invasion bacterial protein activates a plasma membrane receptor to enter our cells. Kudos to @serena_arghittu and @gabriel_hella, and great collaboration with @HeilemannLab
nature.com/articles/s41467-0β¦
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Many thanks to the reviewers for great input (yes) and to the Editor & team of @NatureComms π
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HeilemannLab (ππ» heilemannlab.bsky.social) retweeted
Gen-AI producing fancy data augmentation for Super-resolution microscopy! Great work @AlonSaguy and team! @HenriquesLab @HeilemannLab
18 Oct 2024
If robots could dream of microtubules, how would they look like? An amazing story by Alon Saguy, @ShechtmanLab and colleagues. Proud we could contribute to it
onlinelibrary.wiley.com/doi/β¦
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HeilemannLab (ππ» heilemannlab.bsky.social) retweeted
3 Oct 2024
Our Gentle Rhodamines is finally published @ACSCentSci.
See the healthy cytoskeleton free from photodamage even after 800 frames! π¦Ύπͺ
pubs.acs.org/doi/10.1021/acsβ¦
Great collaboration with Julian Kompa, the Johnsson group, and Spirochrome! @JulianKompa @spirochrome @TianyanL
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HeilemannLab (ππ» heilemannlab.bsky.social) retweeted
11 Jul 2024
3 weeks to go... send us your single-molecule bacterial stories for our Cotswolds get-together!
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HeilemannLab (ππ» heilemannlab.bsky.social) retweeted
10 Sep 2024
Interested in a fully automatic analysis pipeline to quantify and classify your 2D and 3D Single-Molecule Localization Microscopy (SMLM) data in an unbiased way? Have a look at our latest work covering ECLiPSE, developed in the @Melike_Lak lab!
doi.org/10.1038/s41592-024-0β¦ 1/11
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HeilemannLab (ππ» heilemannlab.bsky.social) retweeted
2 Sep 2024
Why reinvent the wheel when you can enhance it? Weβve focused on making SNAP-tag better. @SteffiKuehn developed SNAP-tag2, with an optimized substrate. Faster labeling, brighter fluorescence-this is the upgrade you've been waiting for!
30 Aug 2024
Preprint alertπ¨Did you ever experience issues in labeling kinetics and fluorescence brightness, when working with SNAP-tag in live cells?
Our newly developed SNAP-tag2 system might be the solution!
πCheck out our latest preprint on #bioRxiv: πbiorxiv.org/content/10.1101/β¦
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HeilemannLab (ππ» heilemannlab.bsky.social) retweeted
We see each other next year in Bonn, Germany in #SMLMS2025 hosted by @UEndesfelder and @HeilemannLab
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I am chiming in: fantastic meeting, congratulations and thank you to @HenriquesLab and @MicrobeMatos & entire team! #SMLMS2024 @SMLM_Symposium
Looking forward to #SMLMS2025 and working with @UEndesfelder to make it happen. The bar is high π
. Hope to see you all again in Bonn!
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Well done, Claudia! π
28 Aug 2024
Claudia Catapano from @HeilemannLab presented her PhD work using Single Particle Tracking #SPT to study ligand-dependent membrane receptor activation 𧫠#SMLMS2024 @SMLM_Symposium
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HeilemannLab (ππ» heilemannlab.bsky.social) retweeted
28 Aug 2024
our next talk features @JumanaAHA and her impressive work on chromosomal homolog interactions π§¬π¬ Jumana is also a new PI hiring, start applying now π #SMLMS2024 @SMLM_Symposium
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ππ» great job opportunity for a PhD/Postdoc in a new lab headed by a great young PI ππ» @miCHRIScopy.
Exciting research in a great research environment!
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HeilemannLab (ππ» heilemannlab.bsky.social) retweeted
28 Aug 2024
SMLM community! #SMLMS2024 check out our new preprint, a searchable repository (nano-org) for biological SMLM data allowing comparisons of nanoscale organisation π¨π»βπ» ππ’. Registrations data for uploads encouraged π. Links below.
nano-org.bham.ac.uk
biorxiv.org/content/10.1101/β¦
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