Introducing organellomics - a systems-level view of human cell architecture with 24 organelles. AI-driven 𝗡𝗢𝗩𝗔 (𝗡euronal 𝗢rganellomics 𝗩ision 𝗔tlas) encodes organelle patterns in 1.5M neuron images, enabling holistic insights in cellular biology biorxiv.org/content/10.1101/…

TDP-43 may play a role in neurodegenerative disorders such as #alzheimersdisease and #parkinsonsdisease, even in the absence of detectable aggregates. @UKDRI @Cambridge_Uni @WeizmannScience @EmoryMedicine ow.ly/thRc50X1sgM

Wearable robot gives ALS patients a hand buff.ly/BTxGLnp #ALS #AmyotrophicLateralSclerosis #ALSDisease #ALSTreatment #ALSResearch

IsomiR Utility in ALS Prognostication medrxiv.org/cgi/content/shor… #medRxiv

Super excited to finally see this published! Our new method to use combinatorial staining and deep learning to push the multiplexing boundaries of spatial proteomics!

Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's a dedicated organization to oversee the servers] openrxiv.org 1/n

Excited to share our preprint: "𝐎𝐫𝐠𝐚𝐧𝐞𝐥𝐥𝐨𝐦𝐢𝐜𝐬: 𝐀𝐈-𝐝𝐫𝐢𝐯𝐞𝐧 𝐝𝐞𝐞𝐩 𝐨𝐫𝐠𝐚𝐧𝐞𝐥𝐥𝐚𝐫 𝐩𝐡𝐞𝐧𝐨𝐭𝐲𝐩𝐢𝐧𝐠 𝐫𝐞𝐯𝐞𝐚𝐥𝐬 𝐧𝐨𝐯𝐞𝐥 𝐀𝐋𝐒 𝐦𝐞𝐜𝐡𝐚𝐧𝐢𝐬𝐦𝐬 𝐢𝐧 𝐡𝐮𝐦𝐚𝐧 𝐧𝐞𝐮𝐫𝐨𝐧𝐬"

Delighted to share new work from our lab: MultiPerturb-seq 🎛️❌📥📤 Over the last few years, we've been combining CRISPR screens with multimodal readouts of gene expression (RNA) and chromatin accessibility (DNA). In this study, we bring those together within the same cells.

The pure joy in Gaza as Iranian missiles cover the sky above Tel Aviv.

At AAIC 2024, phospho-tau assays look ready for primary and secondary care. @lunduniversity @wustl @BannerAlzheimer ow.ly/QPzg50SV3Tp

A phase Ib/IIa study of Enoxacin in patients with ALS medrxiv.org/cgi/content/shor… #medRxiv

Interested in 3' UTR changes in scRNA-seq? Check out our: * CPA-Perturb-seq paper * UCSC Perturb-seq tracks (see who regulates your favorite 3’ UTR!) * Seurat extension for polyA site analysis (PASTA) * Deep neural perturbation network (APARENT-Perturb) cell.com/cell/fulltext/S0092…

Birth of a neuron. Stem cell transforming into a brain cell: #neuroscience

RT @slava__bobrov: Human brain anatomy: #neuroscience

My team is working with a substantial arsenal of ML algorithms, analyzing diverse human molecular data. The most intriguing work imaginable. We do science and study human brain diseases, but like a small startup. Come join us!

We're hiring! Biomedical Data Science Researcher to develop ML/AI tools and investigate molecular mechanisms underlying neurodegeneration. Position details and requirements: machinelearning.co.il/job/bi… CV to Eran.hornstein@weizmann.ac.il / Nancyy@weizmann.ac.il #jobopportunity

Two neurons having a conversation, surrounded by some busy microglia doing their job: maintaining neuronal networks and helping with injury, repair, and pruning! The brain is beautiful! 🧠🔬#neuroscience #Microscopy

A confocal microscopy image of Your Majesty, the neuron, the king of the brain jungle 🧠🔬! This one is the classical pyramidal cell, the most common neuronal type in the mammalian cerebral cortex. In blue, staining for PSD95, a major protein in excitatory synapses that helps concentrate and organize neurotransmitter receptors in the synaptic cleft. Each little dark blue puncta shows an excitatory synapse happening between two neurons! Reduction or dysfunction in the PSD95 expression is related to impaired learning and working memory and is observed in diseases such as Alzheimer's and Parkinson's. Staining: 🟠SMI32🔵PSD95 #SynapticSunday @zeiss_micro

Our preprint of 𝑵𝑶𝑽𝑨 is out! A deep representation learning of 24 organelles in 1.5M 🔬 images of human iPSC-dervied cortical neurons. We tested stress, #ALS genetic perturbations, and more. What a fascinating road it was with this one.. 🎢🧠🧪🧫

A new bioRxive from our lab showing a new concept: #Organellomics in #Neurons that distinguishes between cell states and conditions. A huge imaging data set of neurons and an edvanced computational work come together! It was my pleasure to be part of this fantastic work!

Check out our latest preprint about AI-driven 🤖 deep organellar phenotyping of human 🧠 neurons. biorxiv.org/content/10.1101/…