A lab @FredHutch obsessed with translation control and its impact on health and disease. #mRNAtranslation #prostatecancer #bladdercancer #physicianscientist
Joined January 2019
- Tweets 4,009
- Following 610
- Followers 1,956
- Likes 7,578
74 Photos and videos
Ever wonder how toggling protein synthesis impacts cellular identity? Dr. Rashmi Mishra @HsiehLab did and through a clever drug screen discovered that the cap-binding domain of eIF4E regulates lineage fate in prostate cancer. Story hit newsstands today: jci.org/articles/view/199838
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Fred Hutch at #ASCO26: Dr. Sara Hurvitz presents results from the Phase 3 VIKTORIA-1 study, evaluating gedatolisib plus fulvestrant and palbociclib versus standard of care in patients with HR /HER2−, PIK3CA-mutant advanced breast cancer.
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May 26
We are thrilled to share our latest work out today @Dev_Cell! Appendiceal adenocarcinoma (AC) is a rare, aggressive cancer that frequently spreads to the peritoneum. Until now, lack of robust preclinical models has severely limited drug discovery. cell.com/developmental-cell/…🧵👇 🔗
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Today we're celebrating the achievements of three Basic Sciences Faculty!
Dr. Jesse Bloom (@jbloom_lab) for being elected to @theNASciences, Dr. Susan Parkhurst for being named a fellow of @aaas, and Dr. @ToshioTsukiyama for being appointed to the Lycette Endowed Chair.
ALT Please join us today in celebrating Jesse Bloom, Susan Parkhurst, and Toshi Tsukiyama for their recent awards with coffee and pastries on Tuesday, May 26th at 11am in the Weintraub Atrium! Jesse Bloom National Academy of Sciences Susan Parkhurst 2025 Fellow of American Association for the Advancement of Science Toshio Tsukiyama David and Deborah Lycette Endowed Chair for Cancer Research *Coffee and treats provided* Looking forward to seeing you there!
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Congratulations to Dr. Toshio “Toshi” Tsukiyama, professor and associate director of the Basic Sciences Division, on receiving the inaugural David and Deborah Lycette Endowed Chair for Cancer Research. Read more: bit.ly/4eZye3W
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Congratulations to Drs. Pallabi Mustafi and @RubenRaychaud, who recently received Young Investigator Awards from the Prostate Cancer Foundation for their work investigating epigenetic features of aggressive prostate cancer.
Read the full story: bit.ly/4nGuRRB
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May 16
@FDAOncology approved atezolizumab as adjuvant Tx in resected MIBC based on ctDNA #IMVigor011 (IO-naive patients). The candidate population is shrinking due to EV-303, EV-304, NIAGARA trials data but exists @BladderCancerUS @HsiehLab @spsutkaMD @OAlhalabiMD @shilpaonc @DrOmarMian
US FDA Approves #atezolizumab for Adjuvant Muscle-Invasive Bladder Cancer With #ctDNA-Guided Treatment based on data from #IMvigor011. This is the first approval in #BladderCancer using ctDNA. A step forward in our field. - businesswire.com/news/home/2…
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Can #AI help predict which patients will respond to treatment — before months are lost? @JLWrightMD and @PGrivasMDPhD explore how machine learning is unlocking signals in biopsies to guide smarter, faster care for patients with #bladdercancer. Listen here: bit.ly/4tfd6tG
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May 3
Amazing turnout for the Seattle @BladderCancerUS walk to end #BladderCancer! Inspiring words from survivors, family, @PGrivasMDPhD and @JLWrightMD. Teams raised nearly $100,000 for life saving research👏 🤩 #NoOneWalksAlone. @li_haolong @HsiehLab @MartinMaMDPhD @RosaNadalrios
Drs. @PGrivasMDPhD and @JLWrightMD are at @BladderCancerUS’ Seattle Walk to End #BladderCancer today spreading awareness about the disease!
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Drs. @PGrivasMDPhD and @JLWrightMD are at @BladderCancerUS’ Seattle Walk to End #BladderCancer today spreading awareness about the disease!
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Apr 28
Androgen metabolism in prostate cancer: recent advances - out in the May issue of Endocrinology! @EndoSocJournals @TheEndoSociety academic.oup.com/endo?login=…
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A phase 2 study published today in @JCO_ASCO, led by Fred Hutch's @fmilano976, shows that a stem cell product called dilanubicel safely enabled umbilical cord blood transplants in 28 patients. ascopubs.org/doi/10.1200/JCO…
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Apr 23
@MonikaJoshimd & I welcome everyone to open this important phase 3 trial with SG (with G-CSF) pembro vs chemotherapy in advanced urothelial Ca after prior checkpoint inhibitor (CPI) asking CPI rechallenge question! Open @fredhutch & other sites! @KMittalmd @eaonc @HsiehLab
.@MonikaJoshimd and @PGrivasMDPhD are leading #ClinicalTrial EA8231, a phase 3 randomized trial comparing the effectiveness of pembrolizumab and sacituzumab govitecan to standard-of-care chemo in patients with advanced #UrothelialCancer. bit.ly/ea8231-study
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🥳 @fredhutch molecular biologist Dr. Kevin Barry just received a grant from @AmericanCancer to boost the effectiveness of immunotherapy in patients with advanced #melanoma.
Congratulations! bit.ly/41U86je
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Apr 22
Amazing work & broad impact in the field of immunotherapy by Larry Fong @fredhutch @mshadman @VenurVyshak @HsiehLab @AACR #AACR26 @spsutkaMD
Apr 21
A closer look at immunotherapy resistance at #AACR26 from Dr. Lawrence Fong of @fredhutch, exploring how myeloid-driven immunosuppression impacts cancer treatment. #AACR26
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Today! #AACR26
#Bladdercancer care has undergone a sea change in recent years, creating new opportunities and new questions across the disease continuum.
I am looking forward to chairing this session at #AACR26:
Advances in Bladder Cancer Research and Treatment: Pathways to Precision Medicine
Speakers:
Bishoy M. Faltas, @WeillCornell
@MattGalsky, @MountSinaiNYC
@UroDocAsh, @UTMDAnderson
This will be an overview of advances in NMIBC, MIBC and metastatic disease, including perioperative strategies, patient selection, treatment sequencing, biomarkers, MRD, and mechanisms of resistance and recurrence.
Looking forward to an interactive discussion on how new drugs, emerging technologies, and mechanistic insights can help move precision medicine forward in bladder cancer.
🗓️ Link to add to your meeting planner: abstractsonline.com/pp8/#!/2…
There is so much momentum but also a lot of work that still needs to be done!
Hope to see you in San Diego! ##AACR26
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Excited to share STRIPE, our targeted long-read RNA sequencing platform for rare disease diagnosis and variant interpretation. science.org/doi/10.1126/scia…
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Ever wonder how toggling protein synthesis impacts cellular identity? Dr. Rashmi Mishra @HsiehLab did and through a clever drug screen discovered that the cap-binding domain of eIF4E regulates lineage fate in prostate cancer. Story hit newsstands today: jci.org/articles/view/199838
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Thank you to our collaborators - @li_haolong (@fredhutch ), Arnab Sengupta (@GeorgiaCollege), Pete Nelson (@fredhutch ), and Sita Kugel (@fredhutch)
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