In the clinic, we’ve always found that naltrexone’s best effects lasted about 4 hours after dosing. So if you’re using it for craving, take it 1-2 hours before your first drink (or the time you typically start drinking). Ppl who take it in the am but drink in the pm see👇benefit
Naltrexone is evidence-based in preventing relapse in alcohol & opioid dependence. (Donoghue et al., 2015; Krupitsky et al., 2012)
It works by blocking opioid receptors, reducing cravings, & modifying reward pathways.
Here’s what you need to know about its pharmacology, clinical use, & emerging applications. 👇🧵