Joined April 2012
Photos and videos
Ida Lindeman retweeted
Tissue proteomics with clinical value in #celiac disease: - bitly.ws/3fGa2 Great work Anette Johansen and thank you collaborators in particular @SandveGeir for expert ML knowledge! @CeliacDotOrg @UniOslo_MED @Coeliac_UK @AGA_Gastro @coliakiforening

2
3
240
Ida Lindeman retweeted
Very happy to share this story on autoreactive B cells in celiac disease together with @IdaLindeman @LeneHoydahl @ChristophAsb @LouiseFRisnes @JCoDiRC. Here, we identify a population of circulating IgA-switched B cells specific to the self-antigen transglutaminase 2 (TG2).
Generation of circulating autoreactive pre-plasma cells fueled by naive B cells in celiac disease biorxiv.org/cgi/content/shor… #biorxiv_immuno
1
8
25
5,310
Ida Lindeman retweeted
New work from our @UiO_LifeSci ImmunoLingo convergence environment in which we leverage linguistics to formalize the antibody sequence language. arxiv.org/abs/2209.12635. Work led by @MaiSpaceHa, @PRobertImmodels, @pandaisikit. See🧵below by @MaiSpaceHa for details.
27 Sep 2022
New preprint from the ImmunoLingo convergence environment: “ImmunoLingo: Linguistics-based formalization of the antibody language”. We asked: how to define the language of antibody sequences for more efficient antibody therapeutics design? 1/7 arxiv.org/abs/2209.12635
2
13
54
We're looking for an enthusiastic #postdoc to join the Sollid group (med.uio.no/klinmed/english/r…) at the University of Oslo through the #ScientiaFellows program to investigate genetic polymorphisms in adaptive immune receptors. Please share and DM if interested! #postdocjobs #AIRR

7
6
Ida Lindeman retweeted
We used scRNA-seq to assess the combined transcriptome and Ig repertoires of CSF B cells in MS. This revealed a stereotyped B-cell response using IGHV4/IGKV1 in patients carrying certain IGHC alleles! @EurJImmunol #MS onlinelibrary.wiley.com/shar…

10
26
Ida Lindeman retweeted
Happy to share this story on anti-gluten antibodies in celiac disease. biorxiv.org/content/10.1101/… The project was led by Chunyan Zhou @JCoDiRC @UniOslo_MED and is the result of a long-standing collaboration with the Buus lab @uni_copenhagen. Main findings are summarized below.
1
9
36
Ida Lindeman retweeted
So you ran a single-cell RNA seq experiment...now what? Ludvig Sollid @JCoDiRC and @IdaLindeman reviews single-cell approaches in the investigation of celiac disease: nature.com/articles/s41385-0… #Celiac #SingleCell
11
30
Ida Lindeman retweeted
We just released CompAIRR – a tool that reduces greatly the longstanding computational bottleneck of identifying shared identical and similar sequences among large sets of immune repertoires. All the details/links are in the thread below. Feedback is very welcome! @airr_community
We are happy to report a dramatic speedup for one of the core computations for adaptive immune receptor repertoire (AIRR) analysis - the discovery and counting of receptors that overlap between repertoires! Check out our CompAIRR method: biorxiv.org/content/10.1101/… 1/7
1
38
90
Ida Lindeman retweeted
Another new preprint! We combined virtually-docked 3D-antibody-antigen binding complexes with an unbiased in silico oracle to explore at unprecedented resolution the principles of ML-based antibody design with respect to affinity, conformational epitope, and developability. 1/2
1
26
65
Ida Lindeman retweeted
Happy to share our preprint: "A billion synthetic 3D-antibody-antigen complexes enable unconstrained machine-learning formalized investigation of antibody specificity prediction" biorxiv.org/content/10.1101/… Check out Absolut! database software to simulate more github.com/csi-greifflab/Abs…
5
58
122
Ida Lindeman retweeted
Our review on "Immunoglobulin germline gene variation and its impact on human disease" is out. Great collaboration with @immuno_ivana and Ludvig Sollid @JCoDiRC. @airr_community Link: nature.com/articles/s41435-0…
45
151
Ida Lindeman retweeted
AIRR ML: Did you know that baseline machine learning methods can perform well even when disease-associated signals are present in only 2 out of 100 000 receptors in diseased adaptive immune repertoires? Check our latest preprint: biorxiv.org/content/10.1101/… 1/10
2
21
39
Check out our new paper on B-cell responses in multiple sclerosis! We used scRNA-seq and BCR-reconstruction to characterise B-lineage cells in the CSF, and identified stereotypical B-cell responses linked to IgG constant region polymorphisms. biorxiv.org/content/10.1101/…
3
12
41
Ida Lindeman retweeted
1/11 Did you ever wonder whether individuals have the same probability of generating a given antibody sequence? Turns out, they do not – not even twins! We showed that humans – including monozygotic twins – have unique VDJ recombination rules. biorxiv.org/content/10.1101/…
9
118
439
Ida Lindeman retweeted
Over the moon that our study on the predictability of antibody-antigen binding is featured on the cover page of @CellReports! The cover was designed by our resident scientific illustrator @pandaisikit (who's also the first author). Link to paper: cell.com/cell-reports/fullte…
13
50
159
Ida Lindeman retweeted
Beyond happy to share our @immuneml platform, which streamlines your machine learning analyses on adaptive immune receptor repertoire data. It can be extended in all possible ways. Fantastic teamwork with the @SandveGeir lab. Let us know what you think! @airr_community 1/2
Very happy to finally release immuneML – an open-source python platform that streamlines development, application, and benchmarking of immune receptor machine learning for predicting immune status or antigen specificity (immuneml.uio.no). biorxiv.org/content/10.1101/… 1/10
11
45
115