Delighted to announce the opening of my lab at KAIST in Daejeon. My lab will focus on intellectual disability proteins and their impact on brain computations. I'm hiring! For more details, visit ingiehonglab.org. Please RT! Recommendations are welcomed.

We're thrilled to present ESM3 in @ScienceMagazine. ESM3 is a generative language model that reasons over the three fundamental properties of proteins: sequence, structure, and function. Today we're making ESM3 available free to researchers worldwide via the public beta of an API for biological intelligence. Trained with over a trillion teraflops of compute, this is the first time a model of this scale has been trained for biology, pushing the frontier of AI for biological discovery and engineering. ESM3 learns to represent the immense complexity of protein biology, learning from billions of natural proteins. From this training it developed the capability to design proteins, responding to complex prompts combining atomic level details and high level instructions to generate new proteins. ESM3 can explore protein space far beyond natural evolution. We prompted ESM3 to generate a fluorescent protein at a far distance from any known fluorescent proteins, searching an unknown region of protein space, to discover a new fluorescent protein. We estimate this is equivalent to simulating five hundred million years of evolution.

Our paper on MouseGoggles - an open-source mini VR headset for mice - just came out! Really excited about finally integrating eye-tracking into the headset. Nice working with you @hongyu_chang! nature.com/articles/s41592-0… github.com/sn-lab/MouseGoggl…

Amazing work by @Han_L_Tan! These BNC2 neurons shut down hunger before you can pronounce semaglut-. Lots of implications for understanding and treating obesity 🧠🍽️ #Neuroscience #ObesityResearch #Leptin

Brain Molecule Makes Neurons Less Selective Deepening Understanding of Human Cognition—Findings from Johns Hopkins Medicine may help scientists better understand causes of autism, schizophrenia and epilepsy. “We've discovered that the calcium permeable subtype of AMPA receptors has an added role of suppressing the selectivity of a given neuron,” says Ingie Hong, Ph.D., first author and an instructor in neuroscience at the Johns Hopkins University Medicine. “Until now, the role of these specific receptors in the wider mammalian brain as it functions in everyday life has been a mystery.” Full article: oneneurojhu.org/2024/10/14/b…

We’re presenting AlphaProteo: an AI system for designing novel proteins that bind more successfully to target molecules. 🧬 It could help scientists better understand how biological systems function, save time in research, advance drug design and more. 🧵 dpmd.ai/3XuMqbX

Make critical thinking a foundational subject in education. Teach students how to think critically, analyze information, and discern fact from fiction using scientific methods, creating a more discerning and informed society.