An online resource for intestinal cell researchers. Part of the @STEMCELLTech Science News service.
Joined October 2012
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GIVEAWAY! 🤩 Win 1 of 3 pairs of @STEMCELLTech's science socks.🧦
Skip out on the worry of falling behind and get the latest research in your field delivered straight to your inbox with STEMCELL Science News! 🤸
🧡 Subscribe by June 30 for a chance to win: bit.ly/4sFyUzh
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In this @Nature study, researchers develop a molecular glue degrader of HuR that suppresses BRAF-mutant #ColorectalCancer, including tumors resistant to BRAF inhibitors, by disrupting oncogenic RNA regulation.
Learn more:
🔖 go.nature.com/4vCw3rS
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Researchers alongside Drs. Hyun Jung Kim and Donald E. Ingber show that probiotics mitigate radiation-induced intestinal injury by reducing oxidative stress and preserving epithelial integrity in a human gut-on-a-chip model. @CCLRI @wyssinstitute
🔖 go.nature.com/4urxSa7
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Researchers show that SIRT3 drives #GastricCancer progression and cisplatin resistance by stabilizing the mitochondrial transporter SLC25A6 through deacetylation, revealing a potential 🎯 therapeutic target.
📝 bit.ly/4eegTC5
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New work led by Dr. Michael Linnebacher at @unirostock suggests that #TumorTreatingFields show broad anti-cancer activity against colorectal cancer cells.
Furthermore, targeting the resistance-associated gene NAALADL1 may enhance their therapeutic effectiveness.
@JCOPO_ASCO | go.nature.com/4fw318I
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Scientists show that low KIF4A expression is linked to aggressive #GastricCancer, epithelial–mesenchymal transition, and poorer patient outcomes.
Learn more at @SciReports:
go.nature.com/4fyJF2W
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New work from the lab of Dr. Akihiro Ohashi shows that a cDC1-NK/T-malignant cell circuit drives immunogenic remodeling under PD-1 blockade in #GastricCancer.
📖 Learn more: bit.ly/4emdX7P
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Researchers led by Dr. Claudia Janda at @prinsesmaximac have shown that a synthetic Wnt-IL-13 fusion protein enhances intestinal tuft cell activity to promote #MucosalRegeneration and healing in human intestinal tissue models.
🔬 Read it in @jbiolchem: bit.ly/4xaMRYD
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New work from the lab of Dr. Lukas Dow (@dow_lab) at @WCM_MeyerCancer shows that #ColorectalCancers develop resistance to KRAS-targeted therapy through a mix of genetic mutations and adaptive inflammatory cell states.
📖 Read the @Cancer_Cell study: bit.ly/4uiYGJW
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Let's talk about #TuftCells. 🗣️
Drs. Thornton Thompson & Jakob von Moltke explore #gastrointestinal tuft cell biology, including what their evolved functions are beyond helminth sensing, how they detect pathogens, and why tuft cells proliferate dramatically during type 2 responses. bit.ly/4uyCUmd
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New release in @Cell_Metabolism! 📓
Scientists with Dr. Yatrik Shah and Chesta Jain at @UMich reveal that #ColorectalCancers co-opt metabolic cofactors both for growth and for survival under physiologically toxic iron levels.
🤩 Check it out: bit.ly/4wXuiaa
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This @BrJCancer study identifies the mechanisms of acquired chemoresistance in #ColorectalCancer.🎯
Scientists reported GDF15 as a key molecule upregulated in both chemoresistant and high-#stemness cells.
🧫 go.nature.com/3RLHmiT
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Scientists define a signaling cascade in which an intermediate filament rewires transcriptional programs to control cytoskeletal remodeling and motility, providing mechanistic insight into #GastricCancer dissemination. 🚦
go.nature.com/49oDuKQ
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Led by Dr. @DonIngber, scientists from the @wyssinstitute replicate #IBD hallmarks in human-derived organ-on-a-chip devices.
🔗: go.nature.com/4vavt4x
📚: @natBME
When exposed to #carcinogens, the IBD chip shows increased inflammation, gene mutations and chromosome duplication, in contrast to healthy chips. 🔥
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A new study has identified NAT10, an #RNAAcetyltransferase that regulates mRNA stability, as a driver of #ColorectalCancer progression by stabilizing CDK4 mRNA through ac⁴C modification, promoting cell-cycle progression and tumor growth.
📑 Learn more: bit.ly/3Pg0oxd
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A meta-analysis performed by the lab of Dr. Ana Melo at @MethodistHosp has shown that #HER2 expression often differs between primary and metastatic gastric cancers, highlighting the importance of reassessing HER2 status in metastatic lesions to guide targeted therapy.
Learn more: bit.ly/4wHeZm7
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A recent study reveals that Candida albicans cooperates with Fusobacterium nucleatum to drive #ColorectalCancer progression through a Flo9–RadD interaction.
Discover more at @Cancer_Cell:
🔖 bit.ly/3RFaKqY
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A recent study shows that cannabidiol promotes intestinal stem cell regeneration after radiation injury by activating fatty acid β-oxidation.
Learn more here:
🔖 go.nature.com/3R13ntT
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Investigators led by Drs. Frederic J. de Sauvage and Robert Piskol reveal a metastatic cell state in #ColorectalCancer driven by high MAPK and low WNT signaling.
Learn more here:
🔖 go.nature.com/48RB7A0
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Researchers from Fudan University show that HERC2-mediated ubiquitination of DDX21 drives a dormancy-like, radio-resistant state in #ColorectalCancer through the NUCKS1–p21/p27 axis.
🔖 go.nature.com/3P9Mo87
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📢 New in @cddpress!
SEL1L3 suppresses #ColorectalCancer growth and migration by inhibiting HRD1-mediated #EndoplasmicReticulum protein degradation and stabilizing the tumor suppressor STING.
Learn more: go.nature.com/3Ps6pXy
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