Behind the scenes with the Lim lab: Pic 1: Alison Chase and Changwoo (Chris) Lee examining a slide. Pic 2: Changwoo (Chris) Lee, Ben Sanders, Alison Chase, and Janghoo Lim discussing science. Pic 3: Alison Chase, Changwoo Lee, and Janghoo Lim working on transcriptomics and immunohistology.

Spinocerebellar ataxia type 1 (SCA1) is a neurodegenerative disease driven by polyglutamine expansion in ataxin-1. doi.org/10.1172/JCI195723 Here, Changwoo (Chris) Lee @chchrislee, Janghoo Lim @Janghoolim @LimLabYale & team provide strong evidence on the role of oligodendrocyte-specific expression of pathogenic ATXN1 in neuronal malfunction and systemic dysfunction in mouse models of this incurable disease. The image: Purkinje cell torpedoes and myelin debris in the granular layer are increased in OL-SCA1-934 cKI mice. @LeonTejwani #SCA1 #Ataxin1

Oligodendrocyte dysfunction contributes to motor deficits and Purkinje cell axonopathy in spinocerebellar ataxia type 1: doi.org/10.1172/JCI195723

Excited to share that 2 of our graduate students have been awarded fellowships this spring! Alison Chase received an NOA for her @NIH_NINDS F31 Fellowship Annabel Devault received an NOA for her @NAF_Ataxia Graduate Research Fellowship Congratulations 🎉🎉👏

CONGRATS 🎉 to @YaleNeuro's Sreeganga Chandra (@SChandraLab), @Janghoolim, & Stephen Strittmatter, who recently received funding 💰 from the Blavatnik Family Foundation for their innovative research in the field of #neuroscience! 🧠 More 👇 ventures.yale.edu/news/blava…

Congratulations to our newest doctor, Dr. Chris Lee (@chchrislee) who recently successfully defended his thesis!! We are so proud of you! 🥳🥳🥳🥳 @Yale_INP

Major congratulations to our @YaleGenetics grad student on becoming Dr. Luhan Ni (@LuhanNi9) after successfully defending her thesis 👏👏👏👏😻 #Limlabproud

Alzheimer’s disease is the most common form of dementia, affecting more than 50 million people around the world. Its initial description in 1906 sparked a quest to understand the disease that continues to this day go.nature.com/4eSqwoS

Some exciting news – our @Yale_INP grad student Ashley Owens just received a Notice of Award for her F31 Fellowship through @NIH_NINDS which will support her research into #lysosomes and #tau pathology Huge congratulations! 👏🥳🎉

As a new semester gets off to a start, we'd like to highlight our 2 new graduate students who recently joined us for their thesis research🔬 A brief thread 🧵

Annabel Default is a @YaleGenetics🧬grad student who studied chemical engineering and biochemistry at @Northeastern. Her focus in the lab will be elucidating 🔎 the signaling pathway of Nemo-like Kinase in the context of lysosome regulation 🧫

Emma Downey is a @Yale_INP🧠grad student who studied biomedical engineering at @TuftsUniversity. In the lab, she will be growing SCA1 cortical organoids🧫 to use as a model to study disease progression🩻in human cells

Celebrating summer and the 4th with a little lab hike this week🧗‍♂️⛰️🎆🎆

Microglia-astrocyte crosstalk in the amyloid plaque niche of an Alzheimer’s disease mouse model, as revealed by spatial transcriptomics dlvr.it/T7fF03

Congratulations to Rosa Grijalva on passing her qualifying exam. You've oligo-done-it! 🌟🕺🏆 #LimLabProud

Starting off strong with Lim Lab representation at #EMBOmicroglia24 with poster by Ben Sanders (@PrinceoPiermont) today 🎉🎉 Excited to share our work at @EMBO Microglia in Health & Disease, and a beautiful venue here in Genova 🧠🇮🇹

And on Monday our last graduating undergraduate –Byron – presented at the Yale MCDB Senior Poster Symposium🧬 Congrats all 👏👏👏👏

Yesterday our 3 graduating undergraduates – Joy, Rose, and Serena – did a fantastic job presenting their senior theses at the Yale Neuroscience Senior Poster Symposium 🧠🧠🧠

In the latest issue! Contrasting somatic mutation patterns in aging human neurons and oligodendrocytes dlvr.it/T5Nvpb

Climbing fibers and corresponding Purkinje cell complex spike events provide essential instructive signals for associative cerebellar learning nature.com/articles/s41593-0…