The Arc gene (Activity-regulated cytoskeleton-associated protein) and memory engram cell are both central to the neuroscience of learning and memory, and they are functionally linked.
Arc isn’t just a plasticity gene—it forms virus-like capsids that transfer mRNA between engram cells, helps tag active synapses, and enables memory updating. Precise Arc levels are essential: too much or too little disrupts memory. Dysregulation is linked to Alzheimer’s, but targeted rescue shows promise. (Ashley, 2023; Chen, 2024; Kim, 2024)