The podcast that explores the curious mind of Buck Joffrey. Join us and venture beyond the realm of finance and discover Buck's passions for health & longevity.
Joined May 2023
- Tweets 324
- Following 4
- Followers 79
- Likes 10
321 Photos and videos
Despite weighing less than a lab mouse, many bat species live decades longer than their size would ever predict—often with little to no visible decline.
Explore what bats are teaching us about lifespan limits:
youtu.be/Ktb3HJmemZ8
#longevityscience #agingresearch #healthspan
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Longevity Roadmap retweeted
21 Dec 2025
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Longevity Roadmap retweeted
21 Dec 2025
Happy holidays: The AgingBiotech.info/podcasts table is now fully updated thanks to the work of
@Mengyuan_CAI_.
5 new podcasts added including Free Radicals (w/ @teleodaniel & @EricDai_BioE), @DcodLongevity, @reachlevity, & @LRMpodcast.
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30 Dec 2025
As bats age, repair mechanisms strengthen and inflammation stays controlled—suggesting aging isn’t just about damage, but regulation.
Watch the full episode to see what bats reveal about aging biology:
youtu.be/Ktb3HJmemZ8
#LongevityScience #AgingBiology #Inflammation
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23 Dec 2025
Unlike other organs, brain cells (neurons) don’t regenerate easily.
Watch the full episode to understand why the brain is especially vulnerable to aging and what you can do to protect your most vital organ:
youtu.be/__YAwNswiCk
#BrainHealth #Neurodegeneration #HealthyAging
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19 Dec 2025
If you’ve been wanting to reverse your biological age, optimize energy, and reduce risks for chronic diseases, this is your moment.
👉 Grab the Holiday Sale price before it ends:
masterclass.longevityroadmap…
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19 Dec 2025
The effect isn’t cellular replacement — it’s biological instruction. That distinction is central to understanding what regenerative medicine can and can’t do.
Watch the full episode with @bioXcellerator here: youtu.be/N5wRAnQsqXc
#stemcellscience #regenerativeMedicine
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17 Dec 2025
“Stem cells” aren’t inherently equal.
Watch the full episode for a comprehensive discussion on stem cells with @bioXcellerator, and what they can do for your health:
youtu.be/N5wRAnQsqXc
#stemcells #regenerativemedicine #longevityscience #clinicalmedicine #biotech
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12 Dec 2025
Neurodegenerative diseases aren’t driven by suddenly producing “bad” proteins later in life.
The problem is what aging quietly breaks: the brain’s cleanup systems.
Watch the full episode:
youtu.be/M0g8-bj-XvQ
#Neurodegeneration #AlzheimersDisease #ParkinsonsDisease
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12 Dec 2025
🎄 Holiday Sale: $1,997 → $197 🎄
The Longevity Roadmap Masterclass is 90% OFF for a limited time.
If you’ve been wanting to reverse your biological age, optimize energy, and reduce risks for chronic diseases, this is your moment:
masterclass.longevityroadmap…
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10 Dec 2025
Chaperone-mediated autophagy doesn’t just “slow down” with age — the entire architecture of the recycling system breaks.
Watch the full breakdown with Prof. Ana Maria Cuervo:
youtu.be/M0g8-bj-XvQ
#LongevityRoadmap #CellularAging #Autophagy #CMA #AgingResearch
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9 Dec 2025
Cells don’t just recycle—they make selective decisions about which proteins should be dismantled and which should be preserved.
Watch the full episode to see why these mechanisms matter for aging and long-term cellular stability: youtu.be/M0g8-bj-XvQ
#Longevity #Autophagy
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8 Dec 2025
This week, Prof. Ana Maria Cuervo breaks down a major but overlooked driver of aging: the decline of chaperone-mediated autophagy (CMA)—the pathway cells use to identify and remove damaged proteins.
Watch now: youtu.be/M0g8-bj-XvQ
#AnaMariaCuervo #ChaperoneMediatedAutophagy
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5 Dec 2025
When a biological fingerprint appears, is it the spark—or the smoke?
Watch the full episode on brain resilience and aging: youtu.be/PS_oq-xP83Q
#AlzheimersResearch #Neurodegeneration #Biomarkers #BrainHealth #LongevityScience
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4 Dec 2025
Emerging evidence suggests facial aging could reflect inherited longevity traits and biological resilience more accurately than a birthdate ever could.
Watch the full episode: youtu.be/tviGQ6_iklc
#ThrowbackThursday #longevity #agingresearch #biologicalage #healthspan
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4 Dec 2025
Young plasma can reawaken stem cells, sharpen immune function, and push multiple tissues toward a younger state.
Full episode: youtu.be/PS_oq-xP83Q
#Parabiosis #AgingScience #LongevityResearch #Rejuvenation #AntiAgingScience
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2 Dec 2025
Proteins may be the most powerful early indicators of neurological risk we’ve ever had.
Watch the full episode to see how protein fingerprints are redefining early detection:
youtu.be/PS_oq-xP83Q
#BrainHealth #Proteomics #Biomarkers #Neurodegeneration #AgingScience
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1 Dec 2025
This week on Longevity Roadmap, Dr. Tony Wyss-Coray joins us to explore how proteomics, systemic signaling, and machine-learning insights are reshaping our understanding of cognitive aging.
Watch the full episode
youtu.be/S5702pFxf8c
#BrainAging #Proteomics #HealthyAging
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28 Nov 2025
Fresh-frozen Alzheimer’s brains show the same signature the imaging studies hinted at: a sharp drop in cytochrome oxidase activity and clear evidence of mitochondrial failure in the cortical layers where neurons deteriorate first.
Watch the full episode
youtu.be/5FENue61BNs
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26 Nov 2025
To see how energy deficits drive brain aging—and why targeting mitochondrial metabolism may be the key to preventing dementia—watch the full episode with Dr. Francisco González-Lima:
youtu.be/5FENue61BNs
#BrainMetabolism #Mitochondria #BrainAging #CognitiveDecline
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