Alex Puissant, Ph.D., is a Principal Investigator in the Hematology-Oncology Department at the Saint Louis Research Institute & Hospital, Paris, France.
Joined January 2019
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14 Photos and videos
Alex Puissant Lab retweeted
Jun 11
Excited to share our review collection “Metabolic Reprogramming in Cancer: Mechanisms and Therapeutic Opportunities” @Oncogenesis_ A big thank you to all contributing authors. If you are interested in cancer metabolism, I encourage you to read these expert reviews. enjoy!!
Jun 11
🚀📚 Excited to share the launch of the review collection "Metabolic Reprogramming in Cancer: Mechanisms and Therapeutic Opportunities", edited by Shensi Shen and Jean-Ehrland Ricci (@jer_06200).
📖 Discover the Review Collection: nature.com/collections/hejfb…
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Alex Puissant Lab retweeted
By encapsulating an engineered CRISPR-Cas12 therapeutic in a #PhageTherapy delivery system, a team designs a precision antimicrobial therapy for Shiga toxin-producing #Ecoli that cleaves the Stx gene and combats infection in animals. @dbikard @EligoBio scim.ag/4u3Ecob
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Alex Puissant Lab retweeted
Jun 3
Just over 2 weeks to go
Jun 3
The call for late-breaking abstracts for #ISEH2026 is open until 19 June. Submit your abstracts for an opportunity to share timely research with a global audience in experimental hematology! iseh.org/Annual-Meeting/Abst…
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Alex Puissant Lab retweeted
New #GeneEditing systems named PRINCE and Little Prince employ small molecules to control both nuclease and guide RNAs—achieving precise control over the duration of gene editing and reducing off-target edits in mouse models. @Shenzhensuat_sz scim.ag/4nXF2Bp
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Alex Puissant Lab retweeted
Jun 3
Excited to share a publication from my PhD work in Nature Communications. Grateful to Dr. Frederic Bost for his mentorship and to the Ligue contre le cancer for supporting this research.
#NatureCommunications #ProstateCancer #c3m nature.com/articles/s41467-0…
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Alex Puissant Lab retweeted
The new issue of #ScienceTranslationalMedicine is out!
A marker of poor outcomes during invasive candidiasis could inform personalized therapies, a skin temperature study in patients helps answer a longstanding question in narcolepsy research, and more. scim.ag/4qEdJww
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Alex Puissant Lab retweeted
Jan 28
Methylation, acetylation and cell fate dlvr.it/TQcHxX
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Alex Puissant Lab retweeted
A screening study that leverages SPOKE knowledge graphing examines over 1500 known drugs, and reveals that the drug candidate #bavisant has remyelinating and neuroprotective properties in models of #MultipleSclerosis. @InstitutCerveau scim.ag/3ZrG8tJ
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Alex Puissant Lab retweeted
Jan 23
RESEARCH | AE Stewart, DK Zachman, A Puissant, KC Wood, @matthewhirschey et al (@Inserm)
A #MachineLearning based approach probing pathway coessentiality reveals that #ComplexII of the ETC regulates de novo #purine synthesis, and can be targeted for AML
nature.com/articles/s42255-0…
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Nature research paper: Polyamine-dependent metabolic shielding regulates alternative splicing
go.nature.com/459XVZP
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Alex Puissant Lab retweeted
Monitoring markers of #tau protein in the blood can predict functional outcomes in patients recovering from ischemic #stroke better than MRI, according to a comprehensive study of more than 1200 patients. @ISD_Research scim.ag/49oBrqD
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Alex Puissant Lab retweeted
A team applies CT/PET imaging in #tuberculosis lung lesions in marmosets receiving 22 different treatment protocols, and shows imaging can predict known clinical outcomes from shortened and standard regimens. @AldridgeLab @taliagreenstein @TuftsMedSchool scim.ag/49t6twk
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Alex Puissant Lab retweeted
Gene expression profiling of #dengue infections finds that peripheral blood mononuclear cells #PBMC drawn from symptomatic and symptomatic individuals have distinct immune profiles. @sangerinstitute @MahidolU scim.ag/3KMUsti
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Alex Puissant Lab retweeted
Can #HIV become resistant to #lenacapavir?
An analysis of clinical isolates identifies mutations that shift the capsid protein’s lenacapavir binding pocket and endow resistance, but shows these mutations often come at a high fitness cost. @GileadSciences scim.ag/4aKsPeU
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Alex Puissant Lab retweeted
Jan 5
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Alex Puissant Lab retweeted
Small genetic variants occurring naturally from person to person can abolish binding of #MonoclonalAntibody therapeutics to their target, according to a new study. scim.ag/4aR8Hrs
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Alex Puissant Lab retweeted
15 Dec 2025
Researchers find a distinct #Bcell and antibody profile in infants and mothers in an Older Order Mennonite farming community, associated with lower incidence of egg #allergy. @URochester_SMD scim.ag/4psn0r1
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Alex Puissant Lab retweeted
10 Dec 2025
This week's issue of #ScienceTranslationalMedicine has arrived!
Researchers identify a target for an mpox vaccine using AI and reverse vaccinology, a study of a farming community may explain why this lifestyle is linked to fewer egg allergies, and more. scim.ag/3KmPUtv
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Alex Puissant Lab retweeted
7 Dec 2025
Very rich issue of new research manuscripts on myeloid leukemia biology and therapy is out!
Enjoy it and thanks as always @Bims_BiomedNews
biomed.news/bims-tremyl/2025…
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Alex Puissant Lab retweeted
« Secondary-type acute myeloid leukemia is associated with a higher risk of invasive fungal infection during intensive induction therapy. a correlative study on the ALFA 0702 trial. » by Jean-Eudes Fahrner
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