Exciting breakthrough technology from the lab, now live in @CellCellPress ! Instead of cutting the genome where proteins bind (e.g., Cut&Tag), D&D-seq scars the DNA with a deaminase, allowing single cell genome mapping of TFs and chromatin remodellers!

Fire trucks playing New York New York in Astoria

"He even fakes the pain/ Of pain he feels in fact." From "Autopsychography" by Fernando Pessoa. @PPresence @DisquietILP #poetry #poetrycommunity #PortuguesePoets

Finally read Beloved by Toni Morrison....

It was a privilege to reflect on the life and legacy of Greg Hannon in an obituary published in Cell, co-authored with Julius Brennecke. Collaborating on this was a gift: a chance to reminisce, remember, and try to capture what made Greg so extraordinary. bit.ly/4elZcAU

This @NatureBiotech publication takes it to another level, providing the first spatially resolved panoramic view of perturbation responses, capturing not only mRNAs but also total RNA regulatory landscape, including microRNAs, lncRNAs, tRNAs, and other non-coding RNA species.

🤩 spatial panoramic in vivo CRISPR screen via Perturb-DBiT 🤩 Excited to share our collaborative work with @sidichen lab and many outstanding collaborators, now published in Nature Biotechnology! nature.com/articles/s41587-0…

Our stream for Single Cell Genomics Day goes live tomorrow morning at satijalab.org/scgd , look forward to seeing you there for our 10th year!

THIS IS THE BEST PAPER OF 2026 SO FAR, A MONUMENTAL BREAKTHROUGH, A REVOLUTION IN THE FIELD OF INFLAMMATORY CONDITIONS: Interleukin-10 Autoantibodies and HLA-DRB1*01:03 in Inflammatory Bowel Disease | New England Journal of Medicine nejm.org/doi/10.1056/NEJMoa2…

Langston Hughes, "After Many Springs" (1926)

GOOD MORNING NEW YORK CITY.

This poem has gone viral, attributed to Dame Judi Dench! I am both flattered and honoured 😂 but it is mine, so do tag me if you see it. From ‘the right words’ #damejudidench #viralpoem #dontprioritiseyourlooks

Big progress vs cancer, folks. The kind of event curves from randomized trials that we've not seen before for a couple of the most deadly cancers. Congrats to the oncology research community for getting these trial done. #ASCO26, @ASCO

Do single-cell foundation models obey scaling laws? A somewhat thought-provoking new Nature Methods study by the Crawford lab suggests that, for current single-cell foundation models, the answer may be “not really.” Across a broad range of architectures and downstream tasks, increasing pretraining data from hundreds of thousands to tens of millions of cells yielded surprisingly limited gains, with performance often saturating much earlier than expected. This is interesting and provides exactly the kind of rigorous benchmarking our field needs. As Felix Fischer and I commented in the accompanying Research Briefing, such studies help move the discussion beyond model size and computational budgets toward actual scientific utility. At the same time, I am not convinced the key conclusion is that scaling does not work in biology. Rather, it may be that current objectives are not extracting enough information from additional data. Interestingly, in our recent scConcept work, we observe a markedly different scaling behavior, with continued gains as training data grows toward hundreds of millions of cells. The key difference may be the training objective itself: instead of reconstruction-based masked modeling, scConcept uses a contrastive objective that directly optimizes biologically meaningful cell representations. biorxiv.org/content/10.1101/… This raises an interesting question for the field: Have we reached the limits of data scaling, or only the limits of current objectives? -> My guess is that the next generation of biological foundation models will depend less on simply collecting more cells and more on finding the right representation learning principles for biology. Nature Methods paper: nature.com/articles/s41592-0… Research Briefing: nature.com/articles/s41592-0… #SingleCell #FoundationModels #AIforBiology

Not every day you see an odds ratio of 50 (for interleukin-10 autoantibodies and a common HLA allele). ~80% of patients with inflammatory bowel disease (IBD) have this HLA allele These individuals (~3.5% of IBD) may benefit from B cell depletion (such as achieved via CAR T). nejm.org/doi/full/10.1056/NE… nejm.org/doi/full/10.1056/NE…

A central limitation of cellular barcoding analyses has been the loss of native spatial context. With @insitubiology, we developed an adaptable platform for multiclonal lineage analysis that links clonal history to spatially resolved gene expression. cell.com/cell-stem-cell/full…

Finally out in @Cellcellpress! Proteins with long intrinsically disordered regions (IDRs) are prone to misfolding during protein synthesis. This is prevented by mRNA 3′UTRs that act as mRNA-based IDR chaperones. cell.com/cell/fulltext/S0092…

Dr. Gail Roboz @WeillCornell led #research published in @NEJM showing that an all-oral drug combination for older patients with acute myeloid #leukemia (#AML) is an effective alternative to current standard of care, leading to recent @US_FDA approval: bit.ly/4u8SsvP

“My Mayor is Muslim, my bagel is Jewish, my Christian’s Dior… Knicks in 4” — unknown poet, early 21st century, the American Northeast

D&D-seq, a single-cell immune-tethering strategy, captures weak and transient DNA-protein interactions to enable integrated, genome-wide analysis of transcription factor binding across chromatin states @CellCellPress @landau_lab @raimondi_ivan cell.com/cell/fulltext/S0092…