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The Le Group @LeResearchGroup

A newish research group at York University specializing in reaction & catalyst development. We love fluorine!

Joined June 2019
  • Tweets 341
  • Following 297
  • Followers 1,333
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The Le Group@LeResearchGroup
19 Jul 2024
Our first paper on Pd-catalysis, a Suzuki coupling of carbamoyl fluorides is out in @ChemCommun! 🥳 Congrats to @MaryamJPoor, @JesseLeBlanc, @czc_chem and @dcadwallader94. pubs.rsc.org/en/content/arti…

Pd-catalyzed Suzuki-type cross-coupling of 2-pyridyl carbamoyl fluorides

We describe a palladium-catalyzed Suzuki-type cross-coupling reaction of 2-pyridyl carbamoyl fluorides with boronic acids, which provides entry to medicinally relevant pyridyl amides. Mechanistic...

pubs.rsc.org
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The Le Group retweeted
Christine Le@christine_m_le
31 Mar 2025
Strong @YorkUChem representation at the 53rd SOUSCC at U of Guelph! Congratulations to Samantha and Gracia, honors thesis students in the @LeResearchGroup and Caputo lab, for winning outstanding oral presentation awards! 🎉
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Christine Le@christine_m_le
13 Dec 2024
Thank you for this wonderful recognition and opportunity to attend @iupac2025 in Malaysia!
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Eric Keske@EricKeske
3 Dec 2024
Our latest publication now in ASAPs at @Orgmet_ACS! Congrats to @meilin_lim for paper #3. Thanks to @JesseLeBlanc, Charley Garrard and @chriscaputoTO for help with crystallography, and @RenzoniSterling with the TOC! @TrentUniversity @ChemistryTrent pubs.acs.org/doi/10.1021/acs…

Preparation and Metalation of N-Heterocyclic Carbene Ligands with Sterically Tunable 2,6-dialkoxy...

N-Heterocyclic carbenes (NHCs) featuring 2,6-dialkoxyphenyl wingtip groups are synthesized, and their coordination chemistry and properties are studied. Linear [(NHC)CuCl] complexes composed of...

pubs.acs.org
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Slowly working our way up to the legendary Xiao-level scale 😎 thanks @JesseLeBlanc for our largest PDFA top-up yet
The Le Group@LeResearchGroup
5 Feb 2024
We have always assumed PDFA synthesis was indefinitely scalable but this report from the Xiao group shows that is likely the case 🤩 pubs.acs.org/doi/10.1021/acs…
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The Le Group retweeted
Christine Le@christine_m_le
10 Nov 2024
I had a great time at @qomsboc this weekend @chemuoft with the whole @LeResearchGroup! Fantastic plenary lectures by @rebeccois, @hanzyduzit & @diaogroupNYU, complemented by excellent student talks. Thanks for organizing @RousseauxGroup and team!
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Saturday at QOMSBOC is starting strong with a talk from our own @MaryamJPoor on her recent publication on Suzuki couplings of carbamoyl fluorides!
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Jesse LeBlanc@JesseLeBlanc
5 Nov 2024
6 Crystallizations and out of all of them only 1 giant single crystal formed 😍. The structures a catalytic intermediate and was absolutely bonkers 🤯! If you're attending @qomsboc this year drop by and see what it is!
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Be sure to come meet us at QOMSBOC next weekend! The entire group will be in attendance with @MaryamJPoor giving a talk bright and early Saturday morning and the rest of our grad students have posters Saturday night!!!!
QOMSBOC 2024@qomsboc
31 Oct 2024
We can't think of anything scarier than missing out on QOMSBOC! Head to qomsboc.ca to get your ticket! @EWOCEastCAN @chemuoft
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Learning all about techniques for structural assignment from @a_mcknite at group meeting this morning. Ali gave a deep dive of Tsuda and Fuwa’s revision of a couple natural products 🤓
Total Synthesis
@TotalSynthesis
17 Oct 2024
Iriomoteolide-1a and -1b: Structure Elucidation by Integrating NMR Spectroscopic Analysis, Theoretical Calculation, and #TotalSynthesis by Tomohiro Obana, Miyu Nakajima, Kazuki Nakazato, Hayato Nakagawa, Keisuke Murata, Masashi Tsuda, and Haruhiko Fuwa in @J_A_C_S pubs.acs.org/doi/10.1021/jac…
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@dcadwallader94 also gave an overview of the emerging field of ligand-to-metal charge transfer at iron! He highlighted some recent papers from @pushingarrows, the Lu group @WHU_1893 and the Ackerman-Biegasiewicz group @EmoryChem
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NaOH Bartfield, PhD 🧪@NaOHBartfield
14 Oct 2024
Are there any indigenous chemists whose work I can read about? Current or historical, doesnt really matter
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Jesse LeBlanc@JesseLeBlanc
11 Oct 2024
Been working on some nickel chemistry and I'm absolutely obsessed with how beautiful and easy they are to crystallize. 😍😍😍
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This semester has been bittersweet as @MaryamJPoor left us temporarily for an industry internship as part of the TEPD program. We miss her already but we know she’ll make us proud in her new position 🥹
The Le Group@LeResearchGroup
12 Feb 2024
Today @MaryamJPoor presented her research as part of York’s Technology-Enhanced Pharmaceutical Discovery program! Very excited to see what this multidisciplinary collaboration brings 🤓🧬🧫🔬🧪
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Organic Chemistry Portal@organic_portal
30 Sep 2024
organic-chemistry.org/abstra… Tetrabutylammonium fluoride (TBAF) catalyzes a cross-coupling of carbamoyl fluorides with alkynylsilanes
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Christine Le@christine_m_le
27 Sep 2024
An exciting kick-off to the 3rd season of @CIC_ChemInst CORGI seminar series with @MoranLabChem and @dcadwallader94 from the @LeResearchGroup! Register here: cheminst.ca/cic-virtual/semi…
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Chemistry at Thieme
@thiemechemistry
5 Sep 2024
Introducing Christine Le (@christine_m_le), Assistant Professor in the Department of Chemistry at @YorkUniversity and a 2024 Thieme Chemistry Journal Award Winner! Congratulations on this remarkable achievement! 🎉 Read the full interview: brnw.ch/21wMnb8
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There he goes again!
Zichuan Chen@czc_chem
3 Sep 2024
Happy to share my first 1st-author article with @TheNewmanLab! We reported the first α-selective Mizoroki-Heck reaction of vinylboron starting materials. Simple reactions to set up with cool products to get after!
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Congrats to Xavier, who defended his undergraduate thesis last week! 🥳 Xavier is off on a well deserved vacation and will be back at York to wrap up his studies in the fall. Sam will also be staying in the group to begin her undergraduate thesis next week!
The Le Group@LeResearchGroup
27 May 2024
Welcoming undergraduate researchers Xavier and Samantha to the group this summer! Xavier has been volunteering since September and is starting his thesis on expanding fluoride catalysis in the group and Sam is a new volunteer working on cross-coupling reactions ⚗️🥼🧪
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Another of our former undergrads out here crushing it!
Sara Rough@rough_sara
14 Aug 2024
Yesterday, I was given the opportunity to present some interesting research that I did this past summer with the Zheng Lab (@ganglabstyle) at the Princess Margaret Research Cancer Research Centre! Thank you to @UofTPharmacy and @ganglabstyle for giving me the opportunity!
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Some nifty ligand design from our friends in the Lavoie lab! More work featuring the talented @czc_chem 🥳
Jesse LeBlanc@JesseLeBlanc
16 Aug 2024
After several years I am so happy to share the work @vicfr33 and I have worked on making modular guanidine ligands!! pubs.rsc.org/en/content/arti…
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