News and updates from the Lechtenberg Lab at WEHI in Melbourne. Interested in Ubiquitin ligases, protein structures, and drug discovery. Views my own.
Joined September 2018
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4 Dec 2024
Excited to share our latest preprint on @biorxivpreprint: "The RBR E3 ubiquitin ligase HOIL-1 can ubiquitinate diverse non-protein substrates in vitro".
biorxiv.org/content/10.1101/…
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29 Jul 2025
We are still accepting abstracts for selected short talks and posters. The abstract deadline has been extended to this Friday, 1st Aug. More information and registration here: lorneubiquitin.org/ .
7 Jul 2025
📣📣 Lorne Ubiquitin – The Australian Ubiquitin Summit 📣📣
20-23 Nov 2025 in Lorne, Australia
Join us this Nov for the first ubiquitin meeting in Australia. Submit your abstract by 18 July 2025 for oral and poster presentations: lorneubiquitin.org/
Please share and repost.
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7 Jul 2025
📣📣 Lorne Ubiquitin – The Australian Ubiquitin Summit 📣📣
20-23 Nov 2025 in Lorne, Australia
Join us this Nov for the first ubiquitin meeting in Australia. Submit your abstract by 18 July 2025 for oral and poster presentations: lorneubiquitin.org/
Please share and repost.
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LechtenbergLab retweeted
4 Jul 2025
Australia’s First Ubiquitin Summit is here! 🥳
📍Lorne, Victoria | 🗓️ 20–23 November 2025
Join us on the scenic coastline of Lorne for 4 days of cutting-edge ubiquitin science, featuring a fantastic lineup of international speakers covering all corners of the ubiquitin world
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LechtenbergLab retweeted
1 Jun 2025
Join us in Lorne for the 11th ISA. We have a fantastic line up of speakers at a beautiful coastal location in Australia. Hope to see you there!
31 May 2025
Michael Lazarou and I will be chairing the 11th International Symposium on Autophagy (ISA) in Australia from 16-20 Nov 2025!
📍 Location: Lorne, Victoria, Australia
🌐 Register now: isa11.org
Join us for five inspiring days of cutting-edge autophagy research!
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10 Apr 2025
Excited to share our latest work, now out in @LSAjournal. We show that the E3 ligase HOIL-1 can ubiquitinate many different saccharides and describe a chemoenzymatic platform to generate ubiquitinated sugars as tools for studying non-proteinaceous ubiquitination.
2 Apr 2025
The RBR E3 ligase HOIL-1 ubiquitinates Ser/Thr-residues and various disaccharides in vitro and can be used to generate ubiquitinated sugars as tools to study non-proteinaceous ubiquitination @LechtenbergLab @WEHI_research
life-science-alliance.org/co…
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10 Apr 2025
We hope this will be useful for the field. A plasmid for expressing the constitutively active HOIL-1 variant is available via @Addgene: addgene.org/229539/
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LechtenbergLab retweeted
World-first: researchers have discovered what protein #PINK1 looks like in humans and how it is activated, solving a decades-long mystery in the fight against #Parkinsonsdisease. The team hope to use the knowledge to find a drug to stop #Parkinsons.
wehi.edu.au/news/scientists-…
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LechtenbergLab retweeted
7 Feb 2025
Super excited to be joining @RACInational for #MCCB2025 in Darwin #NT this April!!
#chembiol #drugdiscovery #peptides #ozchem
Join keynote speakers Dr Pat Sharp, Dr Chiara Maniaci, Prof. Xin Zhang & Dr Madeline Kavanagh in Darwin (13-16 April) for insights into medicinal chemistry & chemical biology.
🔗 bit.ly/3PNkUl6
#MCCB2025 #MedChem #ChemBio #DrugDiscovery #NT
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LechtenbergLab retweeted
6 Feb 2025
Online Now: Combinatorial mapping of E3 ubiquitin ligases to their target substrates dlvr.it/THqW1q
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21 Dec 2024
For those wanting to try to ubiquitinating sugars themselves: our plasmid for bacterial expression of the constitutive HOIL-1 variant is now available via Addgene: addgene.org/229539/
4 Dec 2024
Excited to share our latest preprint on @biorxivpreprint: "The RBR E3 ubiquitin ligase HOIL-1 can ubiquitinate diverse non-protein substrates in vitro".
biorxiv.org/content/10.1101/…
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LechtenbergLab retweeted
19 Dec 2024
I am looking for a research assistant to join my new lab in Melbourne, Australia at WEHI. Please apply at the link below!
tinyurl.com/4wkt2jve
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LechtenbergLab retweeted
Just announced by WEHI, Sir Gus and the Nossal family: the Sir Gustav Nossal Professor of Immunology. This prestigious new position will lead pivotal research to advance human immunology. Made possible by a generous gift from the Nossal family.
Read more: wehi.edu.au/news/sir-gustav-…
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4 Dec 2024
Excited to share our latest preprint on @biorxivpreprint: "The RBR E3 ubiquitin ligase HOIL-1 can ubiquitinate diverse non-protein substrates in vitro".
biorxiv.org/content/10.1101/…
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4 Dec 2024
We hope that our protocol will enable us and others to generate various ubiquitinated saccharides as tools to further develop the non-proteinaceous ubiquitin field. A plasmid for bacterial expression of the HOIL-1 variant will be available at @Addgene soon.
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4 Dec 2024
Thanks to first author @xiangyi_susie, all members of my lab as well as collaborators and co-authors in the @komander_lab (@WEHI_research), @ethangbaus (WEHI) and @PayneResearch (@Sydney_Uni) labs.
biorxiv.org/content/10.1101/…
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LechtenbergLab retweeted
Interested in Honours, Masters, or PhD studies in medical research?
We have over 70 student research projects starting in 2025, across the breadth of research areas at WEHI.
Explore the opportunities here: wehi.edu.au/education/studen…
#WEHIStudents #StudyInMelbourne #UniMelb
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