@LiMaCancerLab profile picture
Li Ma, PhD @LiMaCancerLab

Professor @MDAndersonNews studying #metastasis & #immune response. @PKU1898 | @WeillCornellGS-@MSKCancerCenter | @WhiteheadInst alum. Views=own

Joined December 2021
  • Tweets 268
  • Following 221
  • Followers 456
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Li Ma, PhD@LiMaCancerLab
21 May 2025
Our new paper in @ScienceTM: In vivo #CRISPR activation screen identifies acyl-CoA binding protein as a driver of #bone #metastasis. Super excited by this discovery! @ACS_Research @AmericanCancer @MDAndersonNews science.org/doi/10.1126/scit…

In vivo CRISPR activation screen identifies acyl-CoA–binding protein as a driver of bone metastasis

ACBP and lipid metabolism invigorate tumor cells to adapt and thrive in the bone, which can be targeted by an FAO blocker or a ferroptosis inducer.

science.org
Science Translational Medicine@ScienceTM
21 May 2025
A clinical study reveals why vaccines for meningococcus can partially protect against gonorrhea, CRISPR screens reveal a new treatment target in bone metastasis, and more in the new issue of #ScienceTranslationalMedicine. scim.ag/3SIKl8W
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Li Ma, PhD retweeted
Science Translational Medicine@ScienceTM
27 May 2025
Leveraging #CRISPR activation screens, researchers identify the lipid metabolism protein ACBP as a key driver of bone metastasis, and show etomoxir or a ferroptosis inducer can prevent bone metastasis in mice. @LiMaCancerLab @MDAndersonNews scim.ag/4dAYFtY
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🦴Our @ScienceTM study discovered ACBP as a metabolic driver of #BONE #metastasis. 🔬 Blocking fatty acid oxidation or inducing ferroptosis shuts down bone metastasis in vivo. 📰 @MDAndersonNews highlight: mdanderson.org/newsroom/rese… @ACKoongMDPhD @DraettaG @CarinHagberg

Study identifies a new driver and therapeutic vulnerability of bone metastasis

Study identifies a new driver and therapeutic vulnerability of bone metastasis

mdanderson.org
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Grateful to my lab and collaborators for this super exciting milestone!
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Bone metastasis remains a major clinical challenge. By identifying ACBP as a metabolic driver of this process and demonstrating the efficacy of targeting lipid metabolism in preclinical models, our work opens new therapeutic avenues for halting bone metastasis.
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Hiring Postdoctoral Fellows for Cancer Metastasis & Immunotherapy research in my lab at MD Anderson! #PostdocJobs #CancerResearch @MDAndersonNews Apply: jobs.mdanderson.org/search/j…

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Li Ma, PhD retweeted
Ivan Zanoni
@Lo_Zanzi
16 Aug 2024
#EveryCellIsAnImmuneCell! Deng @LiMaCancerLab &co show @NatMetabolism that during liver damage, LIFR drives production of CXCL1 by hepatocytes to recruit bone marrow neutrophils. LIFR also increases cholesterol secretion that makes neutrophils reparative! nature.com/articles/s42255-0…

LIFR regulates cholesterol-driven bidirectional hepatocyte–neutrophil cross-talk to promote liver...

Nature Metabolism - The liver tumour suppressor LIFR plays a key role in liver repair and regeneration by orchestrating cholesterol-driven neutrophil hepatocyte growth factor production and...

nature.com
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1-Tweetorial for our @NatMetabolism paper on #metabolic and #immune regulation of tissue repair and #regeneration: rdcu.be/dQ4Za. In 2012, my lab at @MDAndersonNews reported that the cytokine receptor LIFR is a breast cancer #metastasis suppressor (Nat. Med. 2012).
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more replies
16-Here, our findings reveal the mechanisms underlying injury-induced efflux of bone marrow neutrophils to the circulation and damaged liver, and uncover how reparative neutrophils signal to hepatocytes to proliferate in response to liver injury.
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17-Kudos to the first author @Yalan_Deng and my entire team for their hard work and continued inspiration. Huge thanks to our collaborators, @Zhu_Lab, Michael Curran, and Chunru Lin, for sharing their resources and outstanding expertise.
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