Physician-scientist at @CRI_UTSW with a focus on #LiverCancer and organ regeneration.
Joined March 2016
- Tweets 3,300
- Following 648
- Followers 2,924
- Likes 12,006
81 Photos and videos
Pinned Tweet
10 Apr 2023
Somatic mutations accumulate in “normal” non-cancerous tissues (blood, skin, liver). But why are mutant clones selected? Do they merely proliferate more, selfishly? Or can clones adapt to disease? Could they protect tissues? We shed light on this: authors.elsevier.com/a/1gua9… 1/10
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Very excited to be sharing our new paper, just out in Nature Cell Biology! nature.com/articles/s41556-0…
The big question we investigate: How do migrating cells put their front 🔴 and back 🔵 in the right place?
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A central limitation of cellular barcoding analyses has been the loss of native spatial context. With @insitubiology, we developed an adaptable platform for multiclonal lineage analysis that links clonal history to spatially resolved gene expression. cell.com/cell-stem-cell/full…
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Jun 4
Exciting breakthrough technology from the lab, now live in @CellCellPress ! Instead of cutting the genome where proteins bind (e.g., Cut&Tag), D&D-seq scars the DNA with a deaminase, allowing single cell genome mapping of TFs and chromatin remodellers!
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The timing could not be worse. At #ASCO2026, we saw #daraxonrasib double survival in #PDAC, a reminder that decades of NIH research investment are paying off. Yet federal research funding is being cut. The biggest victims won't be scientists... They'll be future patients
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Excited to share our latest study published in @ScienceAdvances. With the An & Zhang labs @UTHealthHouston, we show that monoclonal antibodies targeting PCDH7 inhibit tumor growth and enhance immune responses in multiple KRAS-mutant lung cancer models.
science.org/doi/10.1126/scia…
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Excited to share our new paper: 'LASER couples damage sensing to ESCRT assembly for lysosome repair.' Congrats to dream team @clairegoul and @aakritijain24 for uncovering a new lysosome repair pathway and its connection to neurodegeneration. bit.ly/49FCPoq
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Jun 1
The Ly Lab @CRI_UTSW is recruiting two #postdocs to study intercellular DNA transfer. Join us to tackle fundamental questions at the intersection of genome instability, cell-cell communication, and cancer evolution. Please share! 🙏
Full posting: cri.utsw.edu/careers/
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🚨Seeking 2 #postdocs ⬇️ join the #relentlessdiscovery
#ScienceJobs #SciJobs #JobRxiv #STEMJobs #AcademicTwitter #PhDJobs
Jun 1
The Ly Lab @CRI_UTSW is recruiting two #postdocs to study intercellular DNA transfer. Join us to tackle fundamental questions at the intersection of genome instability, cell-cell communication, and cancer evolution. Please share! 🙏
Full posting: cri.utsw.edu/careers/
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With all the excitement around daraxonrasib, I needed to refresh my RAS inhibitor knowledge, so here we go:
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May 21
We have hundreds of PanINs in our pancreas, especially after age 40. They are a pre-cancerous lesion, but it is fortunately rare for one to progress to cancer (PDAC). Now we know a reason for that. The microenvironment. @umichmedicine @UMRogelCancer
aacrjournals.org/cancerdisco… @CD_AACR
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ONLINE NOW in @CellCellPress: @PeterLyLab has discovered large pieces of DNA can transfer directly between human cells & that DNA can persist, change how the recipient cell functions. Read more about this #relentlessdiscovery ⬇️ cri.utsw.edu/human-cells-can…
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May 12
Molecular insights into early malignant transition of hepatocellular carcinoma dlvr.it/TSW426
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Our preprint led by @M_Mesbah_Uddin @ZhiYu_ACGT and with @AlexBickMDPhD describes the germline genetic drivers and phenotypic associations of clonal hematopoiesis of indeterminate potential across >1M individuals medrxiv.org/content/10.1101/… @medrxivpreprint
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#thesisThursday: Been a week since Greg Mannino from @Zhu_Lab successfully defended! Congrats, Dr. Mannino 😎 and best of luck continuing the #relentlessdiscovery as a postdoc at @WashU.
ALT Greg Mannino stands at a lecturn with a mic and his computer, in the background is a projection screen with an Acknowledgements slide showing, which has two personal family pictures displayed.
ALT Two rows of lab members sit at a long restaurant table, which is full of eaten food and plates. They're all looking at and smiling for the camera.
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May 6
A gene is recurrently mutated in cancer. But do these mutations really cause the disease? Or are they merely selected during normal tissue evolution?
Here we use a surprising data type (patient ages!) to try and answer this question.
Read new paper out @NatureGenet
👇🏻
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Apr 22
This week marks the release of my book Beyond Inheritance 🎉 📖. It tells the stories of patients with mysterious ailments who have been saved by a radical new view of genetics. And how whales can teach us about preserving our DNA as we age. Available now: tinyurl.com/5yjsr97n
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Monday-Tuesday May 4-5 2026 Steel Symposium in Developmental Oncology @MSKCancerCenter #MSKKids mskcc.org/research-programs/…
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Apr 30
Congratulations to the now Twitterless/Xless Ralph DeBerardinis on being elected to @theNASciences!!!
🌟From the desk of @SJMorrison_: It's a great day for CRI, which now has 2 @theNASciences members. Congratulations to Ralph DeBerardinis, M.D., Ph.D., and his laboratory on this recognition for the quality and impact of their work! #relentlessdiscovery
cri.utsw.edu/deberardinis-na…
ALT National Academy of Sciences logo
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ONLINE NOW in @NatMetabolism: McBrayer Lab & first-author @milan95 have discovered cell maturity determines pyrimidine synthesis pathway preference using their new nitrogen metabolism profiling platform, organoid model. Read more ⬇️
cri.utsw.edu/cell-maturity-d… #relentlessdiscovery
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