Thanks @josepjulve for associating us with this review revisiting #atherosclerosis through an immunometabolic lens, highlighting how cholesterol-lowering therapies modulate immune metabolism and inflammation @I2mcT @INSPIREPlatfor1 mdpi.com/3631704 #mdpijcm via @JCM_MDPI

Boosting mitochondria number and function to slow cellular aging washingtonpost.com/science/2… pnas.org/doi/10.1073/pnas.25…

Our last paper Is out! We identify plasma apolipoproteins J and L1 as novel determinants of steatohepatitis (MASH) in individuals with obesity — both improving diagnostic accuracy beyond traditional risk factors. #MASH @INSPIREPlatfor1 @I2mcT link.springer.com/10.1186/s1…

Organ age and mortality in "Plasma proteomics links brain and immune system aging with healthspan and longevity." doi.org/10.1038/s41591-025-0… @brunovellas @I2mcT @LiMitAging

A step forward in aging biomarker research from @INSPIREPlatfor1 @I2mcT & @InfinityTLS! For the first time, single-cell measurement of energy metabolism in T cells from a simple blood test can detect risk of functional decline. #IHU_HealthAge @Madam_Mito academic.oup.com/biomedgeron…

Glad to see that paper from our team on Intrinsic capacity Icope step 1 in Nature Aging today nature.com/articles/s43587-0…

Excited to share our new study conducted within the @INSPIREPlatfor1 IHU HealthAge: apolipoprotein profiling helps improve prediction of cardiovascular events in the general population @I2mcT @ATH_Plus sciencedirect.com/science/ar…

L’équipe de l’IHU HealthAge en collaboration avec le @BuckInstitute fait partie des 40 équipes semi finalistes du @xprize healthspan pour le projet ICOPE INTENSE xprize.org/prizes/healthspan…

The impact on research ? : "Mitochondrial segmentation and function prediction in live-cell images with deep learning" doi.org/10.1038/s41467-025-5… @brunovellas @isaperarnau @RestoreInstitut @InfinityTLS @I2mcT @LiMitAging

Implementing the WHO ICOPE program in clinical practice: three years of lessons from monitoring 27,082 participants… pubmed.ncbi.nlm.nih.gov/3954…

If we look at thousands of proteins (i.e., signals) in the human blood, the protein most associated with chronic physical and mental illnesses is the **same protein** as the top marker for mitochondrial diseases: GDF15 When mitochondria cannot flux energy properly, the cell makes and secretes GDF15 in the blood to alert other cells Some highlight by Cynthia Liu in our group: - GDF15 is the top predictor for most diseases - GDF15 associated with diabetes is among the most significant protein-prevalent disease associations Based on p-value, GDF15 was most significantly associated with disease. - “GDF15 was associated with the most diseases, containing 205 prevalent and 397 incident diseases, generally acting as a risk factor except for three incident diseases (respiratory diseases affecting the interstitium, disorders of magnesium metabolism, and peripheral artery disease).” - “GDF15, similar to its high ranking with protein-disease pleiotropy, ranked second for protein-trait associations, boasting a substantial 428 associations.”Significant associations with many lipid metabolite markers. - Mental disorders like anxiety disorders, depression, and mood disorders, along with mental health-related traits, also exhibited substantial proteomic signatures including elevated GDF15 - “The fluid intelligence score and various types of dementia shared significant proteins such as NEFL and GDF15 (Figure 2G)” - “GDF15, the protein with pleiotropic effects, was causally associated with several autoimmune diseases, including ulcerative colitis and rheumatoid arthritis (Figure 6B).” Data from >53,000 people in the UK Biobank Full paper here: cell.com/cell/fulltext/S0092… Resource to explore your favorite protein or disease/trait of interest: proteome-phenome-atlas.com

Exited to share our latest review with @SoutoPhilipe on #Sarcopenia & the biological determinants of aging; Winner is Mitochondrial dysfunction! 🧬 We dive into the role of geroscience in age-related muscle decline.@brunovellas @INSPIREPlatfor1 @I2mcT sciencedirect.com/science/ar…

The powerhouse analogy has expired Like social organisms mitochondria differentiate and specialize to accomplish complex functions 🧵

IHU Health Age Scientific Advisory Board

Excited to share our collaborative study with @BarteltLab @MoriLabe @HenverBrunetta, now online @embojournal on a novel function of mitochondrial IF1 in thermogenesis. Grateful for the support from IHU HealthAge @INSPIREPlatfor1 @I2mcT @MitoAging embopress.org/doi/full/10.10…

The time to think and inquire are precious. Inquiring means to contemplate a problem without needing an immediate answer, to sit in the unknown long enough that different kinds of answers emerge. Important part of the process of discovery. nature.com/articles/d41586-0…

Congratulations to Y ROLLAND from Toulouse for his last publication about #ICOPE : "Implementing clinical operationalization of sarcopenia: the contribution of WHO ICOPE program." sciencedirect.com/science/ar… @brunovellas @isaperarnau @RestoreInstitut @InfinityTLS @I2mcT

Thrilled to be associated with this study from @BarteltLab, @MoriLab, and the brilliant @HenverBrunetta, uncovering a novel role of mitochondrial IF1 in the reverse mode of ATP synthase, enhancing bioenergetics in brown adipocytes @I2mcT @INSPIREPlatfor1 biorxiv.org/content/10.1101/…

Mitochondrial respiration atlas reveals differential changes in mitochondrial function across sex and age biorxiv.org/content/10.1101/…

Will the Gates Foundation’s preprint-centric policy help open access? nature.com/articles/d41586-0…