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Llorca lab @LlorcaLab
Joined February 2019
  • Tweets 126
  • Following 94
  • Followers 715
28 Photos and videos
A closer look at the mechanism of microtubule nucleation💫. Thrilled to share our new work revealing CM1-activated gTURC. Great collaboration with @sernarina, @DeBritoClaudia, Thomas Surrey and @LudersLab. @CNIOStopCancer @CRGenomica @IRBBarcelona nature.com/articles/s41467-0…

Structural basis of human γTuRC closure during CM1-activated microtubule nucleation

Nature Communications - Here the authors show that CM1 activates human γTuRC by facilitating its complete closure as the nascent microtubule assembles: high-resolution cryo-EM identifies...

nature.com
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Our take on the struture of the R2T complex 🌱 Now out in @Structure_CP! A fun collab led by @alopezperrote and the @AlabadiDavid lab at @IBMCP . Check it out in the next post 👇
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Link to the paper: cell.com/structure/fulltext/…
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Llorca lab@LlorcaLab
25 Sep 2024
The γTuRC saga goes on! This time, we used cryoEM to describe how CDK5RAP2 helps nucleating microtubules by activating the γTuRC nucleator. Another tour de force led by @sernarina and Fabian Zimmermann and a fun collab with @LudersLab @IRBBarcelona. authors.elsevier.com/c/1jpyq…
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Join us in sunny Madrid☀️ on May 2025 for "Machines acting on DNA and RNA" at the @CNIOStopCancer All things D/RNA! 🧬Replication transcription translation chromatin repair processing🧬 Org: @OscarLlorcaCNIO @rfleiro @NogalesLab info below 👇
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Full info, speakers and registration deadlines in: cnio.es/en/eventos/machines-…

Machines acting on DNA and RNA, a molecular mechanistic perspective (#CFM_MolMech)

cnio.es
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Llorca lab retweeted
Ernesto Arias-Palomo@EAriasPalomo
5 Sep 2024
📢Buscamos persona interesada en realizar la tesis doctoral @CIB_CSIC. Ofrecemos contrato predoctoral de 4 años (FPI) para estudiar los mecanismos moleculares de la transposición del ADN usando crio-microscopía electrónica #PIF2024 info: csic.es/es/formacion-y-emple… RT por favor 🙏
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Llorca lab@LlorcaLab
19 Jun 2024
Junior Group Leader positions for AI/BigData, cancer-oriented researchers are available at @CNIOStopCancer. Many fields (Structural Bio, Protein Design, Genomics, Imaging...) are welcome! 🤗 Apply using the link below 👇 and help us spread the word! cnio.es/en/empleo/junior-gro…

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Llorca lab@LlorcaLab
17 May 2024
Thrilled to share our last work @CellRepPhysSci Revealing the molecular mechanism of an anti-tumoral compound inhibiting our favourite system, RUVBL1/2 (at 2.4 Å resolution)🔥 All-@LlorcaLab work led by @CarmenBePaper and @alopezperrote Link below 👇 doi.org/10.1016/j.xcrp.2024.…
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Llorca lab@LlorcaLab
17 May 2024
And a movie with those beautiful high-res densities 🤓
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And also... 🔥pre-print alert🔥 We take a look at our favourite system in plants🌱, the R2T complex, an HSP90 co-chaperone. A study led by @alopezperrote (@CNIOStopCancer) and Alberto Palacios (from @AlabadiDavid's lab at @IBMCP). Check it out 👇 biorxiv.org/content/10.1101/…

The structure of the R2T complex reveals a different architecture of the related HSP90 co-chapero...

Heat shock protein 90 (HSP90) is a molecular chaperone that contributes to the maturation and activation of substrates in multiple cellular pathways. Its activity is supported by various co-chapero...

biorxiv.org
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🔥Paper alert🔥 Another fruitful collaboration with our friends in M. Palacín's lab. Link below 🔗👇 A study led by María Martínez Molledo (@CNIOStopCancer) and Josep Rullo (@IRBBarcelona) elucidating the cryoEM structure of Asc1/CD98hc transporter. Supported by @FundlaCaixa
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And here goes the link to the paper in @NatureComms 📰 nature.com/articles/s41467-0…

Structure and mechanisms of transport of human Asc1/CD98hc amino acid transporter

Nature Communications - Asc1/CD98hc is a key regulator of small neutral amino acid transport in the brain and adipose tissue. Here, authors report the structure of semi-occluded hAsc1/CD98hc and...

nature.com
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Hi, we have uploaded a preprint on @bioRxiv_biochem that you may find interesting. It's the result of a fruitful collaboration (@IBMCP) with @LlorcaLab (@CNIOStopCancer) aimed at understanding the role of the HSP90 cochaperone R2T in plants.👇
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Llorca lab@LlorcaLab
15 Feb 2024
Double celebration today in the lab! 🎉 Today, our senior postdoc María I. Daudén received the "AECC researcher" grant, followed by our undergrad Celia Varela, also receiving the "AECC lab internship" grant. Proud of you! #TodosContraElCancer @ContraCancerEs @ContraCancerMad
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Llorca lab retweeted
Llorca lab@LlorcaLab
8 Feb 2024
🧬REGISTRATION OPEN🧬 ✈️Come to the @CNIOStopCancer for our Molecular Chaperones in Cancer and Protein Quality Control meeting. ☀️Visit sunny Madrid during spring and enjoy our amazing lineup of speakers. Do not miss it, 10-12 June!! cnio.es/en/eventos/molecular…
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PAPER ALERT🔥 We took a deep dive into the microtubule 🔍 using cryoEM ❄️🔬to capture the earliest steps of nucleation by the γTuRC complex. With @sernarina and @DeBritoClaudia leading the way. Proud of our collab with the @surrey_lab at the @CRGenomica ! science.org/doi/10.1126/scie…

Transition of human γ-tubulin ring complex into a closed conformation during microtubule nucleation

Cryo–electron microscopy structures provide insights into the mechanism of microtubule nucleation by the human γ-tubulin ring complex.

science.org
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more replies
We are so incredibly proud of @sernarina. Not only is she a cryoEM powerhouse, but she's also a caring mentor and labmate. Definitely a role model. Thanks for your hard work 💕
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When your paper gets into @ScienceMagazine we take the red carpet out in the lab...
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Llorca lab retweeted
CSIC
@CSIC
2 Feb 2024
Primera ‘película’ a escala atómica de microtúbulos en construcción, un proceso clave para la división celular. El @CRGenomica, @CNIOStopCancer y @IBMB_CSIC resuelven un problema clave para la biología: cómo las células construyen sus microtúbulos. ▶️tiny.cc/huemwz
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