Even if you are "doing everything right" in terms of lifestyle you're likely to be facing ageing diseases in your 80s - @statto at #FoundersLongevityForum @LDNTechWeek Solving this goes beyond lifestyle into rejuvenation style treatments and medicines

Cell therapies have enormous potential in longevity and regenerative medicine more broadly. But why are they still so expensive and hard to scale? Read more from our CSO Partner, Manish Chamoli PhD longgamevc.substack.com/p/sc…

Exciting news - Vincere has teamed up with Beiersdorf, the company behind leading skin care brands like NIVEA and Eucerin, to develop mitophagy-enhancing molecules for anti-aging skin care! You can learn more and chat with the team at: linkedin.com/posts/vincere-b…

1/n Fun journey continues: Our new @CellStemCell paper out on how the Inherent & Dormant Plasticity of mouse naive PSCs can be "Exaggerated" to Directly form ~E8.5 Transgene-Free (TF) Mouse SEMs & WITHOUT inducing 8-16-Morula-like "Embryo Founder Cells". cell.com/cell-stem-cell/full…

@slatestarcodex has written a great article on the burgeoning field of embryo selection, featuring our recently launched company @herasight. Scott has used the technology himself and gives an overview of the field - this is an essential read for anyone curious to learn more.

How can you use Reinforcement Learning to make better proteins and what does a “Move 37” moment in protein design look like? We’re taking a look at ProtRL: a framework for aligning protein language models to your desired distributions using reinforcement learning. Filippo Stocco from Noelia Ferruz' lab is telling us all about how it works, why reinforcement learning is important for protein engineering, and how these proteins perform when tested in our lab at Adaptyv.

The crossover between crypto and longevity folk seems confusing at first... Both require you to deeply question concepts that most people hold as unquestionable: money and death. Worth a listen to @brian_armstrong with @NiklasAnzinger podcasts.apple.com/gb/podcas…

In the sciences, the authority of thousands of opinions is not worth as much as one tiny spark of reason in an individual man. — Galileo Galilei

UK just might become a leader in longevity — watch this great speech in the House of Lords by @mrevgenylebedev:

Why do people avoid directly expressing the desire: "I don't want to die"? It's not just about disappointment: it will happen anyway, so why upset yourself? It's not just about becoming an outcast: people will think you're strange. The fear of death doesn't raise social status. It's about the need for a complete overhaul of one's worldview. Everything must be reassessed. We all consider people whose actions will lead to our death in the future to be bad. But we also can't call those who do nothing, leading to our death, good either. "I don't want to die" is a breakdown of moral principles, if, of course, this desire is overwhelming. "I don't want to die" is a true new ethic, where everything is subordinated to the struggle for existence. You must behave differently if you seriously don't want to die. Calls for the fight for life cause an unpleasant feeling that comes from any moralizing. All these considerations require energy, which the brain deems unacceptable. All these considerations take time to understand what to do. "I don't want to die" is a confrontational position. It's a demand for everyone to act against death. The struggle for existence is a confrontation with the world. Can we do without a struggle? Yes, it has been done before and turned out poorly.

Pet Longevity genuinely seems like it might be the best risk/return opportunity for allocating capital in the longevity space

This paper will make waves in the aging research community and the results will need to be replicated (I would not fully believe it until I see ITP data) but looks very promising. IL-11 and downstream targets are very promising. Congrats to the team and kudos to Singapore! Source: nature.com/articles/s41586-0…

This new paper provides a potential explanation for why psilocybin has such a profound impact on alleviating depression... It indicates a long lasting reduction in self-focused thinking and rumination!

>90% of UK deaths are caused by ageing, so where do the parties stand on longevity science? I looked through the #GeneralElection2024 manifestos! @UKLabour: no mention @Conservatives: nothing @reformparty_uk: rien @LibDems: - @TheGreenParty: nope @theSNP: nada @Plaid_Cymru: zero

Whatever you think of @bryan_johnson you can't deny he is brave... He just completed an experimental gene therapy on himself, editing his DNA, which is potentially dangerous and not FDA approved. And he will probably open-source the results. Hero. youtu.be/bax8to_s07Q?si=lq5b…

I am always shocked at the number of bizarre things people do to "optimize" their health and longevity and yet they don't exercise regularly, sleep 7-9 hours, eat fruits and veggies, build intimate bonds and community, or ever relax. They obsess over the 0.1% but not the 99.9%.

4) Getting a lower score than your chronological age on the latest generation of aging clocks has been shown to: - correlate with reduced risk of all-cause mortality and disease - visibly look facially younger