The pro-inflammatory role of microglia is considered a key driver of Alzheimer's disease. Today @NeuroCellPress discovery of an epigenetic regulator of microglial mitochondria in the experimental model that may be amenable as a target for therapy or prevention
cell.com/neuron/fulltext/S08…
Do not miss this video by Laura Casablanca @CNB_CSIC, in which she explains the latest findings from our article published in @JExpMed. We have identified the transcrptional network that enables a #macrophage to acquire its #macrophage identity.
📽️ New author video of a study by @MRicotelab@CNB_CSIC "A signal-responsive cooperative transcription factor network determines alveolar macrophage identity" (hubs.la/Q04kt2990).
Video summary by Laura Casablanca: hubs.la/Q04ktwv70
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📰 A new study led by researchers from the Spanish National Research Council (CSIC) at the National Centre for Biotechnology (CNB-CSIC) @CNB_CSIC reveals how alveolar #macrophages acquire their identity and specific functions within the lung.
👉 hubs.la/Q04k7pKS0
cell.com/issue/S0896-6273(25… On the cover: In this issue of Neuron, Du et al. @DuSiling show that repeated microglial depletion enables peripheral monocytes from both the blood and skull bone marrow to infiltrate the brain and engraft as monocyte-derived macrophages with distinct identities. Inspired by a passage from the Zuo Zhuan (“The first beat of the drum rouses the soldiers’ spirits; the second weakens their resolve; by the third, they are exhausted”), the artwork depicts three rounds of microglial depletion gradually exhausting the endogenous microglial niche. The two advancing armies represent distinct peripheral sources of invading cells: one arriving from the blood, illustrated by the army bearing the red flag, and the other emerging from the skull bone marrow, portrayed as descending from the mountains. Artist credit: Ying Xu.
Exercise benefits may begin before conception. In mice, parental physical activity before mating shaped offspring body composition, hypothalamic gene expression, and early-life metabolic programming—with effects influenced by parental age and potentially mediated through changes in breastmilk composition. #ExerciseScience#Epigenetics#MetabolicHealth@WuTsaiAlliancepmc.ncbi.nlm.nih.gov/article…