We are MACSYS, an ARC-funded initiative to generate whole cell models for fundamental science, design in synthetic biology, and biotechnology. We compute life.

Joined January 2022
9 Photos and videos
MACSYS-CoE retweeted
Please RT: new @MacsysCoe & @TheoryLivingSys webinar by Prof. Bas Teusink theoryoflivingsystems.org/ev… on Wednesday 22nd of November at 3:30pm AEDT (GMT 11 - Syd/Mel/Can). Very much looking forward to our first whole cell modelling seminar.
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MACSYS-CoE retweeted
One of the important tests for mammalian whole cell models could be to test/explain the multiplicity of phenotypic involvements of functional variants.
Contrary to what most people expect, the selection distributions are actually quite similar across diverse traits. This is probably because functional variants tend to have effects on many traits. biorxiv.org/content/10.1101/…
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MACSYS-CoE retweeted
Take a moment to learn about Julia (the programming language) if you don't already! I think they make some really compelling points in this piece.
Here we show how #julialang enables new biology nature.com/articles/s41592-0… Thanks to @Roesch_E @jgreener64 @adamlmaclean @nassarhuda @ChrisRackauckas Tim Holy, our eagle eyed reviewers & @rita_strack @naturemethods for superb support! I love a good mountaineering analogy 😎
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MACSYS-CoE retweeted
So happy to see this paper finally published 😍. It was a great collaboration and kudos to @Roesch_E and @theosysbio for leading it. Friends in Biology or any Biology-adjacent field, this paper will likely be very interesting to you: nature.com/articles/s41592-0…

Out in final form, our perspective on why the Julia programming language is well-suited to biology: nature.com/articles/s41592-0… Great to do this as part of the @JuliaLanguage community: @adamlmaclean, @nassarhuda, @ChrisRackauckas, Tim Holy and led by @Roesch_E, @theosysbio
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MACSYS-CoE retweeted
Here we show how #julialang enables new biology nature.com/articles/s41592-0… Thanks to @Roesch_E @jgreener64 @adamlmaclean @nassarhuda @ChrisRackauckas Tim Holy, our eagle eyed reviewers & @rita_strack @naturemethods for superb support! I love a good mountaineering analogy 😎

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MACSYS-CoE retweeted
And this is why @MacsysCoe will base whole cell modelling on #julialang
Replying to @ChrisRackauckas
The final result is code that looks like the math but also does not sacrifice features or performance. Yes, that bit right there is runnable code, and that runnable code is one of the fastest chemical reaction simulators out there!
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MACSYS-CoE retweeted
In case anyone missed the original post a while back, here is a *FREE* BioRender equivalent that has image assets compatible with InkScape and other illustrator platforms. bioicons.com/

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MACSYS-CoE retweeted
Excited to announce that we are significantly expanding the computational biology program at @PeterMacRes. Applications now open for 2 group leader positions! Come and work with me! Please share widely. Closing June 1. careers.petermac.org/job/MEL…
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MACSYS-CoE retweeted
Bioinformaticians! Two new group leader positions have opened at PeterMac: careers.petermac.org/job/MEL…

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MACSYS-CoE retweeted
🧵explaining why I won’t be joining institutional #InternationalWomansDay2023 events. If institutions want to be seen as change makers, invest in that. I’ll celebrate you when I see data showing equal recognition and 💰spent on women’s work as on men’s. #Academic #WomenInSTEM 1
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MACSYS-CoE retweeted
Climate change is accelerating the emergence and spread of superbugs, which thrive in warm, wet conditions. @CSIRO @ATSE_au urge governments to tackle antimicrobial resistance before we sleepwalk into a superbug's paradise. @OneHealthAu @ConversationEDU theconversation.com/climate-…
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MACSYS-CoE retweeted
An excellent Monday morning read. A rallying cry and a reminder that it is a thrilling time to be a theoretical biologist.
New wave theory In his Editorial, Associate Editor @p_r_francois highlights the long history of theory for biology & encourages submissions of theoretical papers describing developing and regenerating systems to Development journals.biologists.com/dev/…
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27 Feb 2023
For all intents and purposes we’ve moved into our new digs.
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MACSYS-CoE retweeted
It was impressive reviewing the papers from our field to show how far understanding has come for the quantitative aspects of bacterial cell surfaces and the processes by which they are made rdcu.be/c6iIS @CentreImpactAMR @MacsysCoe @MonashBDI
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20 Feb 2023
The director’s blackboard is on the move to the new MACSYS HQ. See you soon.
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MACSYS-CoE retweeted
How do microbial interactions look like in dysbiosis? We performed a large-scale metagenome-wide metabolic modelling study and found that it largely depends on the disease. Preprint here: biorxiv.org/cgi/content/shor… 🧵1/5

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MACSYS-CoE retweeted
Don’t miss the February issue of @CellSystemsCP! It is all about microbial communities! 🦠 Cool perspectives & reviews and many different opinions on the “key challenges for engineering microbiomes” (including my two cents on the topic). 👇🏼 cell.com/cell-systems/fullte…
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15 Feb 2023
Looking forward to the @arc_gov_au Centre of Excellence Directors’ Meeting in Canberra today.
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