We are MACSYS, an ARC-funded initiative to generate whole cell models for fundamental science, design in synthetic biology, and biotechnology. We compute life.
Please RT: new @MacsysCoe & @TheoryLivingSys webinar by Prof. Bas Teusink theoryoflivingsystems.org/ev…
on Wednesday 22nd of November at 3:30pm AEDT (GMT 11 - Syd/Mel/Can).
Very much looking forward to our first whole cell modelling seminar.
One of the important tests for mammalian whole cell models could be to test/explain the multiplicity of phenotypic involvements of functional variants.
Contrary to what most people expect, the selection distributions are actually quite similar across diverse traits.
This is probably because functional variants tend to have effects on many traits.
biorxiv.org/content/10.1101/…
So happy to see this paper finally published 😍. It was a great collaboration and kudos to @Roesch_E and @theosysbio for leading it.
Friends in Biology or any Biology-adjacent field, this paper will likely be very interesting to you:
nature.com/articles/s41592-0…
The final result is code that looks like the math but also does not sacrifice features or performance. Yes, that bit right there is runnable code, and that runnable code is one of the fastest chemical reaction simulators out there!
In case anyone missed the original post a while back, here is a *FREE* BioRender equivalent that has image assets compatible with InkScape and other illustrator platforms.
bioicons.com/
Excited to announce that we are significantly expanding the computational biology program at @PeterMacRes.
Applications now open for 2 group leader positions! Come and work with me! Please share widely. Closing June 1.
careers.petermac.org/job/MEL…
🧵explaining why I won’t be joining institutional #InternationalWomansDay2023 events.
If institutions want to be seen as change makers, invest in that.
I’ll celebrate you when I see data showing equal recognition and 💰spent on women’s work as on men’s. #Academic#WomenInSTEM 1
New wave theory
In his Editorial, Associate Editor @p_r_francois highlights the long history of theory for biology & encourages submissions of theoretical papers describing developing and regenerating systems to Development
journals.biologists.com/dev/…
ALT Relative counts of PubMed search results by year for a few scientific terms.
It was impressive reviewing the papers from our field to show how far understanding has come for the quantitative aspects of bacterial cell surfaces and the processes by which they are made rdcu.be/c6iIS@CentreImpactAMR@MacsysCoe@MonashBDI
How do microbial interactions look like in dysbiosis? We performed a large-scale metagenome-wide metabolic modelling study and found that it largely depends on the disease.
Preprint here: biorxiv.org/cgi/content/shor…
🧵1/5
Don’t miss the February issue of @CellSystemsCP! It is all about microbial communities! 🦠 Cool perspectives & reviews and many different opinions on the “key challenges for engineering microbiomes” (including my two cents on the topic). 👇🏼
cell.com/cell-systems/fullte…