The Laboratory of Genome Maintenance at the Rockefeller University studies genetic diseases to understand how DNA repair prevents cancer development and aging.
New preprint from our lab: Fanconi anemia DNA repair pathway protects against copy number variation in tumors. Key to understanding of FA-associated and sporadic squamous cell carcinoma development
biorxiv.org/content/10.1101/…
Excited to share (with my 8 followers) graduate student Ernst Schmid’s “SPOC” classifier, which can pick a good AlphaFold-Multimer prediction out of a crowd, and predictomes.org/, a database of PPIs in the genome maintenance space.
biorxiv.org/content/10.1101/…
thank you to @SU2C for the The Phillip A. Sharp Innovation in Collaboration Award: Defining immunotherapeutic potential in genome instability-driven squamous cell carcinomas. Excited about collaborating with Ben Greenbaum lab at MSKCC.
Together we can help save lives now 🙌 #StandUpToCancer is expanding our cutting-edge research portfolio by adding three new research teams with support from the Torrey Coast Foundation, and four awards to top cancer researchers.
Read more at bit.ly/3G27iO4.
A memorable evening and moving celebration of 40 years of Judy Campisi’s laboratory and her contributions to field of senescence and aging. blessed to have Judy as colleague, mentor and friend. People who had trained with Judy came from all over the world or sent their tributes.
It was a real privilege to work on this with Marcin and our wonderful collaborators. We studied large SVs unmapped by short read WGS but detectable by mass balance analysis. Check out the neat tweetorial by @skimomiks here! 🔽
out today in @NatureGenet 🎉!!! our study applying a simple physical principle (mass balance) to deconstruct the notion that you need long reads to detect large variants in cancer nature.com/articles/s41588-0… 1/🧶
Our study on clonal evolution in Fanconi anemia is out in @CellStemCell. In the FA background of chromosomal instability & HSC attrition, trisomy 1q/MDM4-driven p53 downregulation yields clonal hematopoiesis, preceding sAML.
authors.elsevier.com/a/1gX1h…#BMFsm#leusm#mdssm#AMLsm 1/2
It is with heavy hearts that we announce the passing of our beloved colleague and friend, C. David Allis. Aside from his groundbreaking contributions to biomedical science, David will be remembered for his warmth, humility, and relentless optimism.
Just a reminder about the new JCC stipends too!!!!!
Stipend & Expenses:
The basic stipend is $70,000 for the first year, $72,000 for the second year, and $74,000 the third year.
1/ I'm fortunate to mentor two awesome PhD students who received @NIH F31 awards. These pay about 26K in salary. In NYC, PhD students earn around 46K, leaving a 20K gap. It turns out that I cannot use R01/R21 funding to pay for this gap and have to rely on discretionary funds.
If you are a physician scientist who needs more training before transitioning from mentored research to independence, this grant from the Doris Duke Charitable Foundation is for you: ddcf.org/funding-areas/medic…