So happy to finally share this work! Thank you @AnnaVarghese4 @chaiband @EileenMOReilly @MFBerger1 @nikolausschultz for all of your guidance & insight 🧬 Research Briefing: doi.org/10.1038/s41591-024-0…

Featured today by @MSKLibrary: Pan-cancer analysis of biallelic inactivation in tumor suppressor genes identifies KEAP1 zygosity as a predictive biomarker in lung cancer #BiallelicInactivation #TumorSuppressorGenes #LungCancer #CancerBiomarkers #KEAP1 #PrecisionOncology @MariaAPerry @ArielleElkrief @AntonSafonovMD @rohit_thum @MeelisXY @CDebyaniPhD @ARoseBrannon @MLadanyi @PedramRazaviMD @YoninaMG @KristianaGrigo4 @NickyMcGranahan @CharlesSwanton @ronglais dx.doi.org/10.1016/j.cell.20…

That KRAS Wild type #PancreaticCancer is a distinct entity from KRAS mutant disease was also recently reported by @EileenMOReilly & colleagues in their single institution study from @MSKCancerCenter in @NatureMedicine nature.com/articles/s41591-0…

Increased KRAS mutant allele dosage is an important negative prognostic feature that will need to be integrated into clinical practice as we move into the era of 🎯 RAS-directed therapeutics for PDAC. 🔸️ Clinicogenomic landscape of pancreatic adenocarcinoma identifies KRAS mutant dosage as prognostic of overall survival 🔸️ doi.org/10.1038/s41591-024-0…

🧬KRAS mutations in pancreatic cancer @NatureMedicine 🚨95% of pancreatic cancers are KRAS mutant ❗️KRAS mut-allele dosage 🔺,OS🔻 ⁉️Targetting KRAS! 👉doi.org/10.1038/s41591-024-0… @EileenMOReilly @OlcaBasturk @OncoAlert @realbowtiedoc @ArndtVogel #cancer #oncology #MedX

Paper: nature.com/articles/s41591-0… Data for 2,336 patients with PDAC on cBioPortal: cbioportal.org/study/summary… @MSKPathology @CpcrMsk @MSK_DeptOfMed

Excited to share our latest in @NatureMedicine✨ We present a detailed clinico-genomic landscape of pancreatic adenocarcinomas With important implications for RAS 🎯 therapies Expertly co-led by @AnnaVarghese4 and @MariaAPerry. w/@EileenMOReilly & colleagues @MSKCancerCenter

Thrilled to share our recent work in @CellCellPress ✨ We study the extent to which tumor suppressor genes in cancer adhere to Knudson's ‘two-hit’ hypothesis, and their clinical implications. 🧵👇 Also a detailed 🧵 by @EdReznik below: @MSKPathology @MSKCancerCenter

At #AACR23 the coming days with lots of folks from @nikolausschultz's lab! Come say hi! Find us at the @cbioportal and @OncoKB booths most days. Feel free to DM if u want to meet up

If you missed #WCM's COVID-19 vaccine ambassador training, the full session is now live on our YouTube channel! Help your loved ones make an informed decision about getting vaccinated. bit.ly/3ogRTOK

Sharing my simple talking points for people who are hesitant to get #CovidVaccine because they fear vaccine creation was rushed. 🧵

Curious about COVID-19 vaccines? Tune in tomorrow to hear @KizzyPhD's talk at 11:30am ET. Livestreaming details: bit.ly/700Covid

!

Luckily, years of Deep Learning research have honed my ability to sit in front of a graph and refresh every few seconds.