Chair of Drug Discovery at @UCL. Founder, #openscience drug discovery consortia @O_S_M @MycetOS @OSantibiotics. Head, Open Chemistry Networks @thesgconline
Joined February 2009
- Tweets 7,625
- Following 1,001
- Followers 4,135
- Likes 2,811
520 Photos and videos
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4 Feb 2022
Most days I love my research group. But there are some days when I *really* love them. #OpenScience #outreach on our lab's windows in central London @School_Pharmacy. Open science is #inclusive, and drug hunters could be walking right here... @O_S_M @MycetOS @OSantibiotics
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28 Jul 2024
Riverrun, day 2 #scifoo Check out my activity on Strava: strava.app.link/8iPaY8IYALb
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24 Jul 2024
Cycling in to @School_Pharmacy again, first time since COVID. Things that have changed: 1) Lime bikes, flocking like pigeons. 2) 50% of cyclists have ear buds in. If you don't do it in lab, don't do it on the road, people.
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19 Jul 2024
Perhaps surprisingly, we had a talk today from @NASA in @School_Pharmacy providing, finally, a chance to wear my old @NASAVoyager T.
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13 Jul 2024
Weird wardrobe reversal with @aledmedwards at local @School_Pharmacy pub @SkinnersArms1 @thesgconline
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11 Jul 2024
Are you a computational chemist who loves #orgchem mechanisms? We could use a hand in this #openscience project relevant to new #antiviral molecules. Which mechanism is expected to operate in solution? More details at github.com/StructuralGenomic… @RahmanSZSaleem @thesgconline
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20 Jun 2024
Taking #openscience contributions to the next level. @WhitgiftSchool1 has provided their talented students, who have successfully made molecules for @MycetOS, with their own cool, branded labcoats. I have to get me one of those. @DNDi #mycetoma #NTDs
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14 May 2024
Seriously long shot, but is anyone running the #baytobreakers race in San Francisco this Sunday, and willing to pick up a bib packet at the race expo (Berkeley or Presidio) for a Brit who is arriving too late to do so..?
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Matthew Todd retweeted
1 May 2024
#GetInvolved with #openscience. We've identified #fluorosulfonyls as favored warhead for #DENV RdRp. Details at github.com/StructuralGenomic…. Do you have #fluorosulfonyls? We would love to test them!
#antiviral
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Matthew Todd retweeted
A combination of biochemical, structural, and modeling studies identifies OSM-S-106 as an exemplar of a new chemical class of species-specific reaction hijacking inhibitors. @MatToddChem
#malaria #AntimalariaResearch #DrugDiscovery
Read more: nature.com/articles/s41467-0…
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Matthew Todd retweeted
21 Mar 2024
Interested in synthesis and synthesis prediction? @s_marsden and I have a PhD studentship that is collaborative with @Exscientia. Enhanced stipend. Open to UK students (and, in competition, to international applicants) phd.leeds.ac.uk/project/1706…
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19 Mar 2024
Deeply fun to welcome students from @WhitgiftSchool1 to @School_Pharmacy @UCLLifeSciences to analyse samples of a molecule they made for the #openscience drug discovery project @MycetOS We NMR'd, we mass specced, we figured it out. ucl.ac.uk/pharmacy/news/2024… @ResearchInSch
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7 Mar 2024
Love #orgchem? Love palladium catalysis? Love the Miyaura borylation? We do, but there's one we can't get working. We need it to enable high value compounds for #malaria in @O_S_M. See github.com/OpenSourceMalaria… for more. #openscience @yinuo_w @MedsforMalaria @thesgconline
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6 Mar 2024
John Moult kicking off the CACHE Challenge Symposium in Toronto, describing the lessons learned from the CASP protein structure prediction competition @thesgconline
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6 Mar 2024
Yesterday's board dinner of @thesgconline at @UofT Faculty Club with @aledmedwards @HalabelianLab @mattschap @ryanmerkley @LabScribbles @CherylArrowsmi1 (& others not on X..). Such a fun group of talented researchers who advocate, and *do*, #openscience.
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5 Mar 2024
Fragments and #openscience ftw! We've 18 frags bound at the interface of SARS-CoV-2 Nsp10 and Nsp14, and now we need to grow/merge/link. Details at github.com/StructuralGenomic… Live and online at Fragalysis fragalysis.diamond.ac.uk/vie… We can buy/make/measure. @thesgconline #antiviral
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4 Mar 2024
An #openscience project needing community help from computational modellers. WDR91 for host-directed antivirals. We've binders xstal structure. We need to understand the data, particularly the matched pairs. github.com/StructuralGenomic… @thesgconline @target2035 @UCLLifeSciences
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3 Mar 2024
Several #openscience projects in the lab are nicely poised for community inputs. Here's a peach. One of the @thesgconline Open Chemistry Networks needs some simple ureas. You make, we test. Protocols available. github.com/StructuralGenomic… @target2035 @UCLLifeSciences
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13 Feb 2024
“Reaction Hijacking” Antimalarial Discovered!
UCL School of Pharmacy researchers contributed to an open-source project resulting in a novel molecule targeting the #malaria parasite.
Read more here: 👇
ucl.ac.uk/pharmacy/news/2024…
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