Joined January 2017
- Tweets 237
- Following 68
- Followers 970
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15 Photos and videos
Mathias Jucker retweeted
May 28
Limited transmission of cervid prions to nonhuman primates provides insights into the zoonotic potential of chronic wasting disease. My take - Possible limited replication of cwd prions in primates, not entirely ruled out persistence of inoculation. science.org/doi/10.1126/scia…
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Mathias Jucker retweeted
May 12
This is a superb clinicians review of CAA in NEJM, but in my opinion overlooks the fundamental that CAA is essentially a prion disorder with inherited sporadic and transmitted forms just like CJD. Important for public health to acknowledge this fact and its implications.
Cerebral amyloid angiopathy, caused by beta-amyloid deposition in brain blood vessels, leads to lobar cerebral hemorrhage, microbleeds, and white-matter lesions and contributes to cognitive decline.
Learn more in the Review Article “Cerebral Amyloid Angiopathy” by Steven M. Greenberg, MD, PhD, from Massachusetts General Hospital (@MassGeneralNews) and @harvardmed: nej.md/4n9BPyc
Read a clinical case of a patient with cerebral amyloid angiopathy: nej.md/3RoENTG
ALT Neuroimaging features of cerebral amyloid angiopathy.
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Mathias Jucker retweeted
Studying these young Alzheimer's patients led to breakthroughs, but the funding was cut.
npr.org/2026/05/07/nx-s1-575…
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One Blood Marker Is Tied to Cognition and Mortality in People Who Live Past 100 medpagetoday.com/neurology/d… #MedPageToday
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Mar 31
More evidence that Aβ seeds can trigger the full pathological phenotype of Alzheimer's disease.
Mar 31
High-Level Alzheimer Disease Neuropathological Change Following Iatrogenic Exposure jamanetwork.com/journals/jam…
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Mathias Jucker retweeted
Mar 21
Straight From the Heart | Neurology - discussion of two new cases of iatrogenic CAA following heart surgery in childhood. Caused by transmission of abeta prions, this should be fairly uncontroversial now. neurology.org/doi/10.1212/WN…
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Mar 19
as research briefing: A biomarker of Alzheimer’s disease could be a useful diagnostic tool for other amyloidoses doi.org/10.1038/s41591-026-0…
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Mar 16
non-specificity for disease, but specificity regarding mechanism? - pTau elevation in blood as a cellular stress response to the deposition of amyloid
A positive blood tests for #alzheimersdisease might indicate systemic amyloidosis instead, suggesting clinicians should be cautious when interpreting results. @uni_tue ow.ly/xJ5h50YtUGk
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Mathias Jucker retweeted
Mar 12
Elevated serum pTau levels are not specific to Alzheimer´s disease and may also serve as diagnostic tool for the most common types of systemic amyloidosis, with potential utility in distinguishing amyloidosis-related polyneuropathy from polyneuropathy of other etiologies @MathiasJucker nature.com/articles/s41591-0…
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Mar 11
Alzheimer’s Blood Marker Shows Promise for Heart and Kidney Disease Detection bioengineer.org/alzheimers-b…
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Mar 11
Blood marker for Alzheimer’s may also be useful in heart and kidney diseases, via @EurekAlert! @dzne_en eurekalert.org/news-releases…
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Mar 11
it is out! Elevated blood p-tau 181 and 217 levels are not specific to Alzheimer disease and may also serve as a diagnostic tool of ATTR and AL amyloidosis! #alzheimer #biomarker. Wonderful collaboration with 3 European amyloid centers.
@NatureMedicine doi.org/10.1038/s41591-026-0…
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Feb 22
Blood #neurofilament (NfL) could serve as a cross-species biomarker for #aging interventions and #mortality prediction | PLOS Biology plos.io/46iNxiX. -- To better understand mortality predition across an even wider range of species, we are now looking for more samples!
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Feb 19
Neurofilament Light (NfL) may serve as a cross-species blood biomarker for assessing ageing interventions and predicting mortality. It was great fun to measure NfL in all these speceis, even in a crocodile!
Feb 19
Age-related increase in neurofilament light in blood among mammalian species | PLOS Biology @uni_tue @AgingBiology dx.plos.org/10.1371/journal.…
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Feb 19
Age-related increase in neurofilament light in blood among mammalian species | PLOS Biology @uni_tue @AgingBiology dx.plos.org/10.1371/journal.…
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Feb 17
🖤
Feb 17
Very sorry to hear that Prof Byron Caughey has died so suddenly. He was a major figure in the prion field for decades and a generous supporter of our work. Widely known for a collaborative spirit and a warm, encouraging manner, he will be greatly missed.
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We discovered these astrocytic inclusion >25 y ago (DOI: 10.1126/science.1542796); Very satisfying to finally see the genetic linkage. Great work. The Smarcal1-Usp37 locus modulates glycogen aggregation in astrocytes of the aged hippocampus: Cell Systems cell.com/cell-systems/fullte…
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Mathias Jucker retweeted
Jan 21
Ageing promotes microglial accumulation of slow-degrading synaptic proteins @Nature
nature.com/articles/s41586-0…
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Mathias Jucker retweeted
Dozens of people are feared dead and around 100 others seriously injured after a large fire broke out in a bar in the Swiss ski resort of Crans-Montana. ↩️
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Skiing in Crans-Montana
Nichts ist mehr, wie es war. Die silvesterliche Freude ist am heutigen Neujahrstag grosser Trauer gewichen. Leere macht sich breit. In Gedanken bei den Opfern, ihren Familien und den Helfenden.
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