@MechanoImmunLab profile picture
Enrico Klotzsch @MechanoImmunLab

T-cell activation, Super-Res Microscopy, Mechanical Forces, Immunotherapy, Traction Force Microscopy

Joined October 2014
  • Tweets 69
  • Following 241
  • Followers 181
5 Photos and videos
Enrico Klotzsch retweeted
Carmelo Ferrai@CarmeloFerrai
13 Mar 2024
👇🏽👇🏽👇🏽👇🏽👇🏽👇🏽👇🏽👇🏽👇🏽👇🏽👇🏽
Massimo Vassalli@MassiVassi
13 Mar 2024
We are hiring for a 2y post-doc within the @theglasgowcemi to work on on "Brillouin Microscopy of in-vitro bone marrow models to support early diagnosis of leukaemia". Get in touch if you are interested! linkedin.com/posts/massimova…
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Enrico Klotzsch retweeted
Carmelo Ferrai@CarmeloFerrai
7 Mar 2024
Mechanotransduction and how regulates lymphocytes in immunotherapy is what @MechanoImmunLab is presenting right now @Nano4Mech very exciting story!
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Enrico Klotzsch retweeted
Dimitrios L. Wagner@dlwagner13
15 Nov 2023
New #preprint from the lab: using the CD3-zeta gene as an integration locus to redirect T and NK cells with CARs 🎉 Great work by led by @jonas_kath! Following @j_eyquem TRAC approach, we ventured for an alternative locus suitable for more cell types. biorxiv.org/content/10.1101/…

Integration of ζ-deficient CARs into the CD3-zeta gene conveys potent cytotoxicity in T and NK cells

Chimeric antigen receptor (CAR)-reprogrammed immune cells hold significant therapeutic potential for oncology, autoimmune diseases, transplant medicine, and infections. All approved CAR-T therapies...

biorxiv.org
bioRxiv@biorxivpreprint
15 Nov 2023
Integration of ζ-deficient CARs into the CD3-zeta gene conveys potent cytotoxicity in T and NK cells biorxiv.org/cgi/content/shor… #bioRxiv
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Enrico Klotzsch retweeted
Gita Naseri@GitaNaseri
29 Jun 2023
How is Salmonella prepared for efficient host cell invasion? Read more about the dynamic interplay between # Bacterial Flagellum and #SPI-1 during the Salmonella infection cycle in a recent work of our group @Salmo_Lab, @DoaaOsamaSaleh in #PLOSPathogens dx.plos.org/10.1371/journal.…

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Enrico Klotzsch retweeted
Dimitrios L. Wagner@dlwagner13
13 Jan 2022
Reshaping breast cancer's collagen matrix improved T cell infiltration and tumor control in mice. Could an anti-DDR1 mAb be the next weapon in our immunotherapy arsenal against solid tumors? @MechanoImmunLab & I discuss the exciting findings by Sun et al @Nature 2021.
Dimitrios L. Wagner@dlwagner13
13 Jan 2022
Barring the gates to the battleground: DDR1 promotes immune exclusion in solid tumors | Signal Transduction and Targeted Therapy nature.com/articles/s41392-0…
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Finally its online ! together with @Vogel_Lab @LabOxenius @MortezaAramesh special thanks to @MichaelLDustin financial support from @HFSP @SNF Nanoconfinement of microvilli alters gene expression and boosts T cell activation pnas.org/content/118/40/e210…

Nanoconfinement of microvilli alters gene expression and boosts T cell activation | PNAS

T cells sense and respond to their local environment at the nanoscale by forming small actin-rich protrusions, called microvilli, which play critic...

pnas.org
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My first coverart :) #MyACSCover @ACS4Authors #SingleMolecules #Superresolution #proteomics pubs.acs.org/toc/jprobs/20/6 pubs.acs.org/pb-assets/image…
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Enrico Klotzsch retweeted
Francesca Bottanelli@Fran_Bottanelli
15 May 2021
Point 2. Unless you are German...
Edzard Ernst@EdzardErnst
15 May 2021
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Our collaborative work in a newspaper 💪 @schuetzlab @huppalab #immunology #mechanobiology Entscheidende Zerreißprobe: Wie T-Zellen Krankheitserreger erkennen derstandard.at/story/2000126…

Entscheidende Zerreißprobe: Wie T-Zellen Krankheitserreger erkennen

Wiener Forscher messen, mit welcher Kraft ein T-Zellen-Rezeptor an ein Antigen bindet

derstandard.at
Our collaboration on T Cell forces: #singlemolecule #FRET to quantify forces by individual TCRs during #Tcell activation: pN-forces act laterally. SLB fluidity matters! #Schuetzlab, #Huppalab #Stockingerlab ! nature.com/articles/s41467-0…

Temporal analysis of T-cell receptor-imposed forces via quantitative single molecule FRET measure...

Nature Communications - Mechanical forces acting on ligand-engaged T-cell receptors (TCRs) have previously been implicated in T-cell antigen recognition, yet their sensitivity and specificity are...

nature.com
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Enrico Klotzsch retweeted
FiolkaLab@FiolkaLab
27 Sep 2017
Cancer cell migration imaged with isotropic subcellular resolution. Thanks to Jackson Petroll for the great rendering of our data!
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Enrico Klotzsch retweeted
Einstein Foundation@Einstein_Berlin
23 Apr 2021
Viola Vogel @Vogel_Lab, Bioingenieurin @ETH, erforscht als Einstein Visiting Fellow @BIH_Innovations @ChariteBerlin die mechanischen Kräfte in Zellen. Im Podcast teilt sie ihr Nano-Wissen wie ihre Sicht auf's große Ganze: #Pandemie, #Politik & #Forschung ➡️t1p.de/o61z
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Our new paper on: Nanoconfinement of Microvilli Alters Gene Expression and Boosts T cell Activation. together with @Vogel_Lab @LabOxenius funding from @HFSP . biorxiv.org/content/10.1101/…
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our latest paper together with researchers in Australia: Nuclear Leukocyte Immunoglobulin-like Receptor A3 Is Monomeric and Is Involved in Multiple Layers of Regulated Gene Expression and Translation pubs.acs.org/doi/10.1021/acs…

Nuclear Leukocyte Immunoglobulin-like Receptor A3 Is Monomeric and Is Involved in Multiple Layers...

The leukocyte immunoglobulin-like receptor A3 (LILRA3) is a soluble protein primarily expressed by peripheral blood monocytes and is abundant in sera of healthy donors. Extracellular LILRA3 is...

pubs.acs.org
Our Review on B cells in Immunotherapy @ActaBio
Acta Biomaterialia@ActaBio
15 Mar 2021
REVIEW by Professor Enrico Klotzsch: External cues to drive B cell function towards #immunotherapy @MechanoImmunLab @ETH_en @HumboldtUni @DRFZ_Berlin @ChariteBerlin sciencedirect.com/science/ar…
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Our collaboration with the labs of Profs. Jeschke and Allain finally online. Big congrats especially to Laura and Leonidas !
Nature Chemical Biology@nchembio
8 Mar 2021
New work from Gunnar Jeske, Frédéric Allain, and colleagues demonstrates the precise quantification of protein fractions and intramolecular distances in condensed and dispersed phases of FUS. Free to read at rdcu.be/cgpvs. nature.com/articles/s41589-0…
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Enrico Klotzsch retweeted
HFSP@HFSP
28 Jan 2021
HFSP Young Investigators Enrico Klotzsch @HumboldtUni and Jonas Ries @EMBL and colleagues have developed a traction force #microscopy platform which enables the forces exerted during T-Cell activation to be measured > bit.ly/3pqj9vH
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Super excited to see our work finally be published. pubs.acs.org/doi/10.1021/acs… #nanoletters #mechanobiology #Immunology #microvilli

Functionalized Bead Assay to Measure Three-dimensional Traction Forces during T-cell Activation

When T-cells probe their environment for antigens, the bond between the T-cell receptor (TCR) and the peptide-loaded major histocompatibility complex (MHC) is put under tension, thereby influencing...

pubs.acs.org
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Functionalized bead assay to measure 3-dimensional traction forces during T-cell activation - Studying the force exerting mechanisms of T-cells with our TFM bead assay. #bioRxiv #mechanobiology #TFM #Tcells disq.us/t/3rv6vlg

Functionalized bead assay to measure 3-dimensional traction forces during T-cell activation

When T-cells probe their environment for antigens, the bond between the T-cell receptor (TCR) and the peptide-loaded major histocompatibility complex (MHC) is put under tension, thereby influencing...

biorxiv.org
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Excellent mentor & state of the art research !
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