Our contribution to understanding influenza virus. At UW Madison. @uwmadisonMMI
Joined June 2015
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84 Photos and videos
We love genetic approaches to define virus:host interactions. Knockout screens are powerful, but...technical constraints limit what you can find. Could we devise a screen where viral fitness pinpoints the key regulators of replication? (spoiler - yes cell.com/cell-host-microbe/f…) 1/10
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This was the result of tenacious work and deep thinking by Cason King, and offers a legacy that reflects who he was as a scientist. I thank other lab members and our collaborators in the labs of Judy Smith and @LangloisLab, and @BWFPATH for supporting risky science. 9/10.
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Find more here 10/fin.
x.com/cellhostmicrobe/status…
31 Aug 2023
Pathogen-driven CRISPR screening. @MehleLab develop transcriptional regulation by pathogen-programmed Cas9 (TRPPC) where viruses encoding sgRNAs alter host gene expression to affect their own fitness.TRPPC for influenza shows TREX1 tempers DNA self-sensing cell.com/cell-host-microbe/f…
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It's been a busy work for the lab. Thomas (holding 🍾) passed his @UWMadisonMDTP qualifying exam with aplomb. Very excited to see him tackle his project as a dissertator. Congrats Thomas.
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Excited to announce the successful thesis defense by newly minted Dr. @graceschaack (seen riding her thesis gift, a T-Rex). Great public presentation and closed-door defense. Super proud to have her as a lab alumna, and returning to the clinic to complete her MD. Congrats!
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Mehle Lab retweeted
26 Apr 2023
Congratulations to CMB Alums, Mitch Ledwith and Dan Tremmel, the 2022 Raymond L. Erikson Exceptional Thesis Award recipients! 🎉
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Mehle Lab retweeted
22 Dec 2022
Studying how #influenza virus engages the cellular environment, @bakerlabLBRI @MehleLab &co find that host cells use #AlternativeSplicing to embed #antiviral proteins in #metabolic enzymes, protecting host defenses from viral countermeasures #PLOSBiology plos.io/3VnlJS1
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When is an antiviral protein not antiviral? It's all about context. Cason summarized our current thinking about the subtle balance between pro- and antiviral activities. Free access for 50 days authors.elsevier.com/a/1fvVU…
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The fun begins at #ASV2022. Come see the exciting work from the lab with presentations Saturday by Jordan (W5-12), Sunday by Cason (W16-6) and Grace (W16-9), and Tuesday by Andy. All lab members are available to offer expert, local advice on best places for food, coffee and beer.
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Mehle Lab retweeted
15 Jul 2022
Influenza A virus undergoes compartmentalized replication in vivo dominated by stochastic bottlenecks
@kaaamato @mehlelab @tcflab @UWMadisonMMI
#influenza #flu #virology
go.nature.com/3PqiuXw
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Our NSV talks highlighted some of the fun projects in the lab. If you found them as interesting as we do, and you're looking for a postdoc, reach out. We're looking for someone to join our team. See pic for details. Drop a line to chat, or find Andy at #NSV2022.
ALT Postdoc add for Mehle Lab.
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