@MichonneauDavid profile picture
David Michonneau @MichonneauDavid

MD, PhD, hematologist @HopSaintLouis Professor of hematology @univ_paris_cite INSERM U1342 @Leukemia_Inst

Joined January 2022
  • Tweets 140
  • Following 264
  • Followers 288
14 Photos and videos
David Michonneau retweeted
Science Translational Medicine @ScienceTM
Apr 10
Scientists uncover pre-treatment signatures in monocytes, myeloid cells, and T cells that predict corticosteroid resistance in patients with acute #GVHD, hinting steroid resistance is an intrinsic property of immune cells. @MichonneauDavid @Leukemia_Inst scim.ag/4cxL1sB
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New in @ScienceMagazine 🧬 Thrilled to share our last paper Corticosteroid resistance is predetermined by early immune response dynamics at acute graft-versus-host disease onset | Science Translational Medicine science.org/doi/10.1126/scit…

Corticosteroid resistance is predetermined by early immune response dynamics at acute graft-versu...

Steroid-resistant acute graft-versus-host disease is set at disease onset and leads to distinct cell-to-cell cross-talk and immune trajectories.

science.org
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This work is the result of a truly collaborative effort between @inserm @Institut_IRSL @HopSaintLouis @APHP @Leukemia_Inst @Siric InSitu, @universiteparis @cryostem_FR
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👏 I would like to thank all our collaborators, especially Sophie Le Grand for her outstanding scientific work and @nivallet, and all our funder @FLeucemieEspoir @fdmaladiesrares @HPNFranceAM Fonds de dotation CSL behring Siric InSitu and InIdEx immuno-oncology @univ_paris_cite
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Mitochondrial metabolism and signaling direct dendritic cell function in antitumor immunity | Science science.org/doi/10.1126/scie…

Mitochondrial metabolism and signaling direct dendritic cell function in antitumor immunity

Antitumor immunity requires conventional type 1 dendritic cells (cDC1s). How cDC1s maintain functional fitness in the tumor microenvironment remains unclear. In this study, we established that...

science.org
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David Michonneau retweeted
Waggoner Lab @LabWaggoner
6 Nov 2025
Multiplexed imaging of acute GVHD gastrointestinal biopsies revealed epithelial remodeling and alteration in immune composition, offering insight into disease pathology science.org/doi/10.1126/scit… @leeat_keren @WeizmannScience
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Happy to share our last article in collaboration with @nofar_azulay and @leeat_keren @WeizmannScience in @ScienceTM A spatial atlas of human gastrointestinal acute GVHD reveals epithelial and immune dynamics underlying disease pathophysiology science.org/doi/10.1126/scit…

A spatial atlas of human gastrointestinal acute GVHD reveals epithelial and immune dynamics...

Multiplexed imaging of aGVHD GI biopsies revealed epithelial remodeling and alteration in immune composition, offering insight into disease pathology.

science.org
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doi.org/10.1084/jem.20242180

Gut microbiota–derived TMAVA is a modulator of acute CNS-GVHD

In this study, we report that microbiota depletion exacerbates acute graft-versus-host disease in the central nervous system, driven by microglial activati

rupress.org
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Diet outperforms microbial transplant to drive microbiome recovery in mice | Nature nature.com/articles/s41586-0…

Diet outperforms microbial transplant to drive microbiome recovery in mice

Nature - Experiments in mouse models show that proper recovery of the intestinal microbiota following depletion, with or without faecal microbiota transplant therapy, is dependent on syntrophic...

nature.com
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Great collaboration with Robert Zeiser ⁦@Uniklinik_Fr⁩ ⁦@Leukemia_Inst⁩ ⁦@univ_paris_cite⁩ Teduglutide for treatment-refractory severe intestinal acute graft-versus-host disease - a multicenter survey | Bone Marrow Transplantation nature.com/articles/s41409-0…

Teduglutide for treatment-refractory severe intestinal acute graft-versus-host disease - a multic...

Bone Marrow Transplantation - Teduglutide for treatment-refractory severe intestinal acute graft-versus-host disease - a multicenter survey

nature.com
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AhR activation mitigates graft-versus-host disease of the central nervous system by reducing microglial NF-κB signaling ashpublications.org/bloodadv…
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Happy to share our last paper, published with @SpringerNature in @BMTjournal, about the French experience with belumosudil in the treatment of steroid-resistant cGvHD. Best ORR 57.4% including 14.7% of CR in patients who previously received at least 2 LOT rdcu.be/efZg9

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Thanks to all collaborators, French centers of #alloHSCT and to @SFGM_TC. @APHP @HopSaintLouis @Leukemia_Inst @univ_paris_cite
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doi.org/10.1038/s41409-025-0…
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David Michonneau retweeted
GvHD Hub
 @gvhd_hub
30 Mar 2025
CONGRESS | #EBMT25 | POSTER David Michonneau @MichonneauDavid, @HopSaintLouis @univ_paris_cite shares findings from a real-world retrospective analysis of belumosudil in treatment of #cGvHD. The results were consistent with the findings from the ROCKSTAR trial with no new safety signals identified. Follow our live feed for more updates: gvhdhub.com/medical-informat… #GvHD #MedicalCongress @TheEBMT
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