Antibody Engineer | Biochemist | Dedicated to Improving Human Health | Senior Investigator, National Cancer Institute (NIH) | Views My Own

Joined August 2009
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It is such an honor and privilege to work with a group of talented and dedicated trainees, colleagues and collaborators @NCIResearchCtr @IRPatNIH to develop new cancer therapeutic targets. @NanLizea @danli_502 @pan_jiajia @gerard_hoeltzel @CachauRaul
Development and optimization of CAR T cells targeting glypican-1 for pancreatic cancer therapy. nature.com/articles/s41467-0… #CancerResearch @natrescancer @MitchellHo @NanLizea @theNCI @NCIResearchCtr @IRPatNIH
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Mitchell Ho, PhD retweeted
11 Sep 2025
🎉 It’s ON – CAR T day 2025 starts today! 📍 See you from 09:00 AM at the Faculty of Medicine – Research Center - 1 place de Verdun, 59000 Lille, France 🗓️ Check today’s highlights on the visual below 👇 For the full program 👉 cartday.org/program-2 Let’s kick off two days of inspiring discussions, cutting-edge science, and valuable connections in the CAR T field! 💬🧬✨ #CARTday #CARTday2025 #CARcells #Lille2025 #InternationalEvent #eventprofs @CHU_Lille - @univ_lille - @sfiimmunologie - @i_yakoub_agha - @DrOlivierBoyer
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Mitchell Ho, PhD retweeted
24 May 2025
I discuss the urgent crisis from the loss of federal support of science in the US and recent clinical gene editing breakthroughs with @WalterIsaacson & @amanpour on @AmanpourCoPBS, airing on @PBS tonight at 11 pm ET, and on @cnni earlier today. Pls share! youtube.com/watch?v=8YhJM6zx…
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Mitchell Ho, PhD retweeted
🥳 Our 2nd most downloaded article in 2024: Cancer therapy with antibodies by Paul, Gabelli, @MitchellHo, van Elsas & colleagues bit.ly/4hXKvnw @JohnHopkins @theNCI @NIH @NatResCancer #NRCtop10of2024

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It has been a great day! Thank you for inviting me to meet with wonderful faculty members and students at OSU and give a lecture at the Annual Meeting of the Pelotonia Institute of ImmunoOncology. @OhioStatePIIO @theNCI @NIH @IRPatNIH
Excited to feature Dr. @MitchellHo @NIH at #PIIO_2024 with his seminar: "Engineering #Antibodies and #TCells to Target #Glypicans in #Cancer". 6th Annual #PIIO Symposium.🧪✨
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Honored to give a lecture at the Annual Meeting of the Pelotonia Institute of ImmunoOncology at Ohio State University @OhioStatePIIO @OSUCCC_James @Zihai @IRPatNIH @theNCI
Great talk from @MitchellHo @NIH on engineering antibodies and T cells to target glypicans in cancer. @OhioStatePIIO @OSUCCC_James
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Mitchell Ho, PhD retweeted
Register today for the Sixth Annual Pelotonia Institute for Immuno-Oncology (#PIIO) Symposium! go.osu.edu/io2024 Dec 2-3, Vitria on the Square, 14 E. 15th Ave, 2nd Floor, Columbus, OH 43201 (across from Ohio Union)
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Proud to listen to Dr Dan Li @danli_502 present our work on engineering T cells to target GPC3 in HCC at #ILCA24. @NCIResearchCtr @IRPatNIH @NCI_Training
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Fantastic opening session “Bench To Bedside: Emerging Therapeutic Targets” #ILCA24 by @Valeriechew29 @TimGreten Dr Greten and I discussed basic and clinical research on liver cancer immunotherapy @NCIResearchCtr @IRPatNIH
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Glad to share our new paper describing the discovery of a camel nanobody that mimics a TCR targeting the pMHC complex derived from an intracellular HPV tumor antigen and the generation of CAR-T cells against cervical cancer. @CSHinrichsMD @NCIResearchCtr @IRPatNIH
CAR-T cells based on a TCR mimic nanobody targeting HPV16 E6 exhibit antitumor activity against cervical cancer through NFAT and NF-κB signaling dlvr.it/TFCDSb
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Honored and humbled to receive the Asian American Engineer of the Year award. Will be giving a lecture on engineering antibodies and T cells to target glypicans in cancer. #AAEOY @NCIResearchCtr
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Mitchell Ho, PhD retweeted
Let’s take a closer look at recent #JITC article: “rhIL-7-hyFc, a long-acting interleukin-7, improves efficacy of CAR-T cell therapy in solid tumors” by @MitchellHo & @danli_502 from @NCIResearchCtr & @NeoImmuneTech. 1/8
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CAR T cells based on our humanized rabbit monoclonal antibody, called hYP218, targeting mesothelin epitope close to cell membrane, are very effective against mesothelin-positive tumors. @NCIResearchCtr @NIHClinicalCntr
Anti-mesothelin hYP218 Chimeric Antigen Receptor T Cells—read this article featured in the AACR Journals Collection on Developmental Therapeutics. bit.ly/3XlryUB @MitchellHo #openaccess
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Mitchell Ho, PhD retweeted
🚨Latest paper just hit in @JournalofNucMed 🚨 It's got... ✅Single domain Antibodies. ✅PET imaging. ✅#LiverCancer Buckle up! Thread time. 🧵 1/x jnm.snmjournals.org/content/…
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Our new study demonstrates that combination of an engineered IL-7 and CAR-T cells targeting GPC3, GPC2, and Mesothelin can greatly enhance anti-tumor activity in liver cancer, pediatric cancer and ovarian cancer. @NCIResearchCtr @NeoImmuneTech @danli_502
New #JITC article: rhIL-7-hyFc, a long-acting interleukin-7, improves efficacy of CAR-T cell therapy in solid tumors bit.ly/4cQBue7 @MitchellHo
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So proud of Laura Hutchins, a postbaccalaureate fellow in our lab @NCIResearchCtr @NIH_OITE, who was selected to give a talk #PEGSummit @PEGSboston for her work on a new antibody-directed TCR targeting GPC2 for treating neuroblastoma.
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I am happy to share the latest review on cancer therapy with antibodies @NatureRevCancer @NCIResearchCtr. It was a pleasure to be part of the team led by Suman Paul and Shibin Zhou @JohnsHopkins
NEW content online! Cancer therapy with antibodies dlvr.it/T6rryP
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Traveled to Beijing this week to give a keynote lecture at the Advanced Therapies Beijing Summit 2024. Had a great discussion with companies about collaborating on developing new cell therapies for treating liver cancer and other solid tumors.@NCIResearchCtr
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Very proud of Dr Dan li @danli_502, who received “Outstanding Postdoctoral Fellow Award” from Dr. Douglas R. Lowy @theNCI. She presented our new development of camel nanobodies and CAR-T cells targeting B7-H3 for treating cancer at CCR FYI Colloquium @NCI_Training @NCIResearchCtr
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Dr Dan Li @danli_502 @NCIResearchCtr @EurekaThera is presenting our poster on newly engineered CAR-T cells based on gamma/delta TCR platform targeting glypicans in solid tumors @AACR #AACR24
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