Some stories remind us why we do this work. This is one of them. Beautifully written, deeply human, and a powerful reminder that behind every breakthrough are decades of courage, persistence, and hope. If pancreatic cancer—the Shadow—can be wounded, then hope exists for every cancer still waiting for its breakthrough. Here's to the scientists, clinicians, patients, and advocates who refuse to give up. The future feels closer than ever.

Exciting work from @OSUCCC_James (@Zihai Li Lab) identifies ZFP148 as a hidden brake on cancer-fighting #Tcells. Remove the brake, unleash stronger #immune responses, and move one step closer to more effective immunotherapies. 🧬🛡️ #CancerResearch #Immunotherapy #BuckeyeScience

Today marks 100 days since the opening of the new #OSUWexMed University Hospital! 🏥 To celebrate this milestone, we are sharing an exclusive look at our journey with a before-and-after photo gallery: wexnermedical.osu.edu/our-st… 📸 @ohiostateap and Walsh Turner

🚨 Another major milestone for #CancerImmunotherapy research at @OhioStatePIIO! Congratulations to @DrSTANtheMAN on receiving a new #NCI R01 award to advance groundbreaking research on #mitochondrial reprogramming in #tumor_associated_macrophages & new strategies to overcome tumor-driven #immunosuppression. This important work has the potential to uncover new therapeutic approaches that strengthen #AntiTumor_Immunity & improve outcomes for patients with #cancer. Congratulations, Dr. Huang, & the entire research team! 👏

Future cancer breakthroughs include inspiring #FutureScientists. 🔬 Today, #PIIO postdoctoral researcher Dr. Jay Mandula (@Zihai Lab) welcomed @OSUCCC_James CAMELOT students to the @Pelotonia Research Center, sharing his journey into #CancerResearch and highlighting how #ImmunoOncology is transforming patient care.

Proud to see our PhD student, @MostafaIHA, present his work on the single-cell and spatial landscape of RCC brain metastases @OSUCCC_James @OhioStatePIIO @Pelotonia. Using single-nucleus RNA-seq, spatial transcriptomics, and computational biology, his research explores mechanisms of immune dysfunction and therapeutic resistance in CNS metastases. Excited to see this work advance our understanding of brain metastasis biology and precision oncology. #KidneyCancer #BrainMetastases #SingleCell #SpatialTranscriptomics #PrecisionOncology #HasanovLab #OSUCCC #CodeToClinic

🎉 Congratulations to our colleagues! 🎉 Drs. Lynn O’Donnell & @AshleyAKrull have been elected to prestigious leadership roles with the International Society for Cell and Gene Therapy. Dr. O’Donnell joins the Global Board of Directors & Dr. Krull will serve as Regional Vice President–Elect for North America. We’re proud to see their leadership and expertise recognized on the global stage! 🌍👏

🚨 Reminder: Don’t Miss Dr. Christian Jobin’s Seminar! 🚨 Join us today (Friday, June 5) from 12–1 PM in 115 BRT for a Distinguished Professor Seminar featuring titled: “Bacterial-derived small molecules in cancer: New therapeutic opportunities?”  ✨ Dr. Jobin is a leading expert in #immunooncology whose work focuses on establishing the functional impact of #microbiota in cancer development. 🍽️ Lunch will be provided — come learn, connect, and enjoy! 👉 Do not miss it!!!

🎗️ Join Team Buckeye-Guts-in-Gear (@ZCMlab) June 17 for Wellness Against Cancer! 🥗🏃‍♀️🤝 Learn how #wellness & #nutrition support #cancer prevention & research 💚@Pelotonia. #CancerResearch #GutHealth #Pelotonia #BuckeyeNation Donate or learn more 👇 zcmlab.org/team-buckeye-guts…

Exciting news from @OSUCCC_James #PIIO👏 Congratulations to @A_Wieland_PhD on receiving support from the Elsa U. Pardee Foundation for his project, “Targeting intracellular oncoproteins with innovative antibody-based therapeutics.” Advancing the future of cancer immunotherapy—well done! 🧬✨

CEO and Director W. Kimryn Rathmell, MD, PhD, and her @OhioState oncology team have brought Buckeye Nation to #ASCO26. We’re proud to represent The James at the @ASCO Annual Meeting, where our experts are sharing info and insights from our work to create a cancer-free world.

Excited to share our #ASCO2026 poster presentation by our postdoc alumni @BetulGokYavuz1 @UChicago 🌟 physician👩‍⚕️👩‍🔬scientist Heme/Onc fellow. Deciphering the Genomic Landscape of Renal Cell Carcinoma Brain Metastases 📜biorxiv.org/content/10.64898… 📽️ hasanov-lab.github.io/galler… This study could not have been possible without multi-institutional collaboration and support from @UTMDAnderson @EJonasch @WinshipAtEmory @bilenma @Hacettepe1967 @hanalioglu @HKUniversity #DavidJHShih, funding and resources @KidneyCancer, @OSUCCC_James @OhioState @OSUPIIO, @HasanovLab bioinformatics team #PengLi @joseovandor @AleLaFerlita90 #KidneyCancer #RCC #BrainMetastases #PrecisionOncology #CancerGenomics #MachineLearning @ASCOTECAG @OSUCCC_James @ASCOPost @ASCO @KidneyCancer @kidneycan @urotoday @OncoAlert @oncodaily @OncLive

🎉Huge congrats to @DrSTANtheMAN on securing an NIH NIGMS MIRA (R35) award! 🎉 This outstanding achievement will advance research on #metabolic_reprogramming in reparative #macrophages. Well deserved and excited for what’s ahead!

🚀 Get ready for an exciting #PIIO research-in-progress seminar! Discover how targeting PDE3A can supercharge #antitumor #immunity in #lungcancer. 📅 June 3 | 🕛 12 PM | 📍 BRT 115 🎤 Jay Mandula, PhD (Zihai Li Lab) Cutting-edge science breakthrough insights and PIZZA —be there!

🚨 DO NOT MISS! 🚨 Join us for the #PIIO Distinguished Professor Seminar featuring Dr. Christian Jobin — a global leader in #immunooncology & #microbiome research 🌍🔬 🗓 Friday, June 5, 2026 🕛 12–1 PM 📍 115 BRT 🎤 Topic: “Bacterial-derived small molecules in cancer: New therapeutic opportunities?” With cutting-edge insights into how microbiota shape cancer, this is a must-attend event! 💡🔥 #PIIO #ImmunoOncology #CancerResearch #Microbiome #Seminar

🏆 Congratulations to Dr. Lingbin Meng on receiving the Conquer Cancer Foundation Career Development Award at #ASCO2026! Her project, "CNPY2 in Metastatic ccRCC: Biomarker Validation and Mechanistic Insights into Tumor Progression," aims to advance our understanding of kidney cancer biology and improve patient outcomes through biomarker-driven research. A special congratulations as well to mentors Dr. @Zihai Li and Dr. Lai Wei for their leadership and commitment to developing the next generation of cancer researchers. #ConquerCancer #KidneyCancer #ccRCC #CancerResearch #ImmunoOncology #ASCO #TheJames #OhioStateResearch #FutureOfCancerCare

🔬✨ Special Seminar Alert! Join the #PIIO Center for Innate Immunity and Inflammation (#CIII) for an exciting talk: 💡 “Visualizing & manipulating immunity with light: From viral infection to cancer immunotherapy” Speaker: Dr. Minsoo Kim (University of Rochester) 📅 Thursday, May 28, 2026 ⏰ 12–1 PM 📍 3001 PRC 🍽️ Lunch provided! Don’t miss cutting-edge insights into optogenetics & immunotherapy 🚀 #Immunology #CancerResearch #Seminar

🚧 Exciting progress for the future of #CellTherapy at the and the @OSUCCC_James! The @OhioStatePIIO visited the Polaris campus site that will soon become home to the new & expanded #GMP cell processing laboratory — a major step forward in advancing next-generation cellular #immunotherapy research and clinical translation. 🧬⚙️ The new space will include four mobile #GMP manufacturing units. This expanded infrastructure will help accelerate the development and delivery of innovative #CellTherapy trials and @OhioState -developed immunotherapies for patients. 🚀🧫🏥

✨ Thank you, Dr. Ankita Saini (#EugeneOltzLab, #MIIProud)! ✨, for an outstanding presentation at today’s #PIIO Research-in-Progress seminar 👏 🧬 “Cis-regulatory circuits in #ILCs and #Thcells” offered valuable insights into the evolving understanding of #immune_cell_regulation and function.

Study points to need for biomarker testing in all non-small cell lung cancer cases @rolfolab @ChristianRolfo @OSUCCC_James cancer.osu.edu/news/study-po…