Attn eVOLVER users & enthusiasts. 2 BIG developments! 1) New open-source eVOLVER wiki, which will be a hub for guides and documentation: khalil-lab.gitbook.io/evolve… 2) eVOLVER software version 2.0 is now available! Read about the new features on the forum: evolver.bio/t/evolver-wiki-s…

The New World Screwworm (NWS - despite it’s name is a cousin of the blowfly 🪰) is a scourge to livestock like cattle (🐄) and other warm blooded animals larger than a squirrel (🐿️). We eradicated it in 1966 in the U.S., pushed it back to Panama thanks to the USDA and held it at bay for more than half a century. It broke through and it’s back. But we’re on it together with the @USDA and the interagency; @DARPA is developing novel technologies to safely and efficaciously eliminate the risk that invasive species’ pose! 🚫🪰 ✅🐄 🫡🇺🇸 Thank you for the highlighting coverage @DefenseScoop !

Exciting breakthrough technology from the lab, now live in @CellCellPress ! Instead of cutting the genome where proteins bind (e.g., Cut&Tag), D&D-seq scars the DNA with a deaminase, allowing single cell genome mapping of TFs and chromatin remodellers!

Please fund such tech dev and data generation efforts and please support academic labs where all this innovation is truly happening. 10/10

Check out this Associate or Senior Editor opportunity recruiting.ultipro.com/AME11… @ScienceMagazine

Great stuff, @sudpinglay and team!!

Lovely study by the team, showing how TF specificity emerges from weak and multivalent interactions! (a property we've been obsessed with modeling, designing and engineering in cells 😍)

🚨 An exciting frontier is bringing synthetic biology to MULTIcellular systems. To effectively engineer them, we need design principles. What are the benefits of group formation? What are the costs? See our new preprint led by @HeidiKlumpe to learn more!👇 biorxiv.org/content/10.64898…

Sean Eddy developed profile HMMs in the 1990s, ultimately leading to his HMMER project, which includes JackHMMER that AlphaFold relies on. Apparently his work has been determined to be "of absolutely no value to the US taxpayer". Obviously that's not true. npr.org/2026/05/21/nx-s1-582…

Happy to share this in its published form! More than any project I've worked on, this was a huge team effort, so thank you so much to that team! Especially @ajrferrari nature.com/articles/s41586-0…

HONORED to receive the Kuwait Prize! A testament to the achievements and hard work of Khalil lab members past and present. It’s an honor to be recognized as a scientist, and especially meaningful to celebrate my background as a Palestinian-Jordanian 🙏 tinyurl.com/2jvrjszb

1/9 New preprint from the Sternberg Lab in collaboration with the Nishimasu Lab! We uncover how the DRT3 antiphage immune system pairs two reverse transcriptases, one RNA-templated and one protein-templated, to build a double-stranded DNA effector. doi.org/10.64898/2026.05.04.…

The manufacturing step for CAR T has always been ripe for innovation. Here, Gattinoni and Kochenderfer groups show that pharmacologic enrichment of memory-like Tscm cells boosts CD19 CAR T expansion and durable persistence in patients, even at low doses! cell.com/cell/fulltext/S0092…

🚨 Excited to share a new paper in Cell! Human genetics led us to HOTSCRAMBL, a HOXA-locus lncRNA that regulates 🩸#stemcell self-renewal and HOXA9 splicing, with implications for AML. Amazing work by @lvchosen1 with @silvirouskin, @Armstrong_dfci, and many more! cell.com/cell/fulltext/S0092…

How do transcription factors (TFs) that recognize the same DNA motif end up binding different places in the genome? 🧬 We're excited to show you how we tackle this question in our new bioRxiv pre-print! doi.org/10.64898/2026.04.27.…

1/ Excited to share our new paper in Science: “Toward life with a 19-amino acid alphabet through generative artificial intelligence design.” @ColumbiaSysBio @ColumbiaBME @Columbia science.org/doi/10.1126/scie… 🦠🧬🛠️🖥️💥

Breakthroughs in mammalian synthetic biology happen when bold ideas meet the right audience. Could your research define the next frontier of medicine? Submit your abstract now: bit.ly/4jQmrFj #mSBW2026 #SyntheticBiology #MammalianSystems #CallForAbstracts

New preprint alert - 5 years in the making! Using high-throughput microfluidic enzyme kinetics, we profiled 190 clinical variants of SHP2, a phosphatase linked to developmental disorders & cancer (1/8) biorxiv.org/content/10.64898… @Stanford_ChEMH, @czbiohub, @bioe_stanford

Busy week for the Khalil lab getting ready of our big move next week! P.s. Graveyard of Oligos 🧬 from our prolific former postdoc @willmshaw