Engineer and problem solver with an interest in nutrition and n=1 personal experimentation in diet, exercise and lifestyle. Alter-ego of @VirtuallyNathan
Joined June 2018
- Tweets 4,609
- Following 650
- Followers 2,077
- Likes 1,873
335 Photos and videos
12 Jul 2025
Love the window seat
The window seat on a plane is an incredible modern blessing. Imagine our ancestors getting to take in such a view. They would have been stunned, speechless. And yet, some close the shade and do what? My God.
I can't understand those who shut the shade, and shut out the world.
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18 Jun 2025
Got my VO2Max as measured by indirect calorimeter over 60ml/min/kg!
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5 Jun 2025
Another Nature paper on Cysteine this week!
“Cysteine depletion triggers adipose tissue thermogenesis and weight loss”
nature.com/articles/s42255-0…
@anabology @Joeb_AD
31 May 2025
"Unravelling cysteine-deficiency-associated rapid weight loss"
"conditional cysteine restriction resulted in the most substantial weight loss [...] amounting to 30% within 1 week. We found that cysteine deficiency activated the integrated stress response [...] leading to the induction of GDF15 and FGF21"
nature.com/articles/s41586-0…
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5 Jun 2025
“Commercial methionine restriction (MR) diets contain 0.17% methionine compared with normal levels of 0.86%, but notably, the MR diets also lack cystine”
… what?!
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31 May 2025
"Unravelling cysteine-deficiency-associated rapid weight loss"
"conditional cysteine restriction resulted in the most substantial weight loss [...] amounting to 30% within 1 week. We found that cysteine deficiency activated the integrated stress response [...] leading to the induction of GDF15 and FGF21"
nature.com/articles/s41586-0…
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31 May 2025
CoA scarcity stalls β‑oxidation and the TCA cycle, forcing a wasteful spill‑over of glycolytic and TCA intermediates into urine, amplifying the integrated‑stress‑response that drives GDF-15 and FGF21 transcription; more details in: biorxiv.org/content/10.1101/…
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31 May 2025
Human data:
N = 59 participants with overweight or obesity (73% women) were randomized stratified by sex to an 8-week plant-based dietary intervention low (~ 2 g/day, SAAR) or high (~ 5.6 g/day, control group) in sulfur amino acids.
SAAR led to a ~ 20% greater weight loss compared to controls (β 95% CI - 1.14 (- 2.04, - 0.25) kg, p = 0.013)
pubmed.ncbi.nlm.nih.gov/3819…
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29 May 2025
Polygenic score time!
Wow, 100%ile for migraines. Never had one, nor has anyone in my family.
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29 May 2025
I don’t really drink much anymore, nor do people in my family. I drank in college, but that’s about it.
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29 May 2025
The list goes on. Am I missing something? This seems like totally useless nonsense?
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24 Apr 2025
I have even bigger plans
23 Apr 2025
I have plans that I cannot share with you right now because the haters will sabotage me
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10 Apr 2025
If I order “whipped cream” and you give me “whipped topping” - straight to jail, no trial.
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